scholarly journals Beta-thalassemia intermedia with ischemic transients misdiagnosed as multiple sclerosis: A case report

Author(s):  
Fereshteh Ghadiri ◽  
Mohammad Ali Sahraian ◽  
Abdorreza Naser Moghadasi

The article's abstract is not available.  

2016 ◽  
Vol 74 (6) ◽  
pp. 688-692
Author(s):  
Jean-Maxime Girard ◽  
Guillaume Drevin ◽  
Jean-François Brasme ◽  
Serge Pissard ◽  
Pascal Reynier ◽  
...  

Author(s):  
Fioravante Capone ◽  
Francesco Motolese ◽  
Tiziano Luce ◽  
Mariagrazia Rossi ◽  
Alessandro Magliozzi ◽  
...  

2020 ◽  
Author(s):  
Evan T Cohen ◽  
Nicole Cleffi ◽  
Marianne Ingersoll ◽  
Herb I Karpatkin

Abstract Objective Blood flow restriction (BFR) training, in which an inflatable cuff partially occludes blood flow around the proximal portion of a limb, coupled with low-intensity resistance training (LIRT) has resulted in gains comparable to traditional progressive resistive exercise in healthy populations. The use of BFR with LIRT may enable people with multiple sclerosis (MS) to improve strength without an increase in fatigue. The purpose of this case report is to describe the use of a BFR/LIRT program for a person with MS. Methods (Case Description) The patient was a 54-year-old woman with a 13-year history of primary progressive MS with an Extended Disability Severity Score of 3.0 out of 10. She received a BFR/LIRT program for both lower extremities (LE) biweekly for 12 weeks. Outcomes measured at baseline and at 6 and 12 weeks included the 12-item Multiple Sclerosis Walking Scale (MSWS-12), Fatigue Severity Scale (FSS), Patient-Specific Functional Scale (PSFS) (goals: running for exercise and pleasure for 45 minutes, 100% confidence in negotiating a flight of stairs, confidently and safely drive without restriction), and 14 LE strength tests. Results The intervention was well tolerated without adverse events. After 6 weeks, the MSWS-12 score improved; however, it did not exceed minimum detectable change (MDC). FSS was unchanged. All PSFS goals improved beyond MDC, and improvements in strength exceeded MDC in 2 out of 14 tests. After 12 weeks, MSWS-12 improvements persisted and the FSS score improved, but neither exceeded MDC. The PSFS improvements persisted. There were improvements exceeding MDC for 8 out of 14 strength tests. The remaining 6 strength tests improved but did not exceed MDC. Conclusion The patient had measurable improvements following the use of a BFR/LIRT program. BFR/LIRT may be an option for strength training in people with MS; however, research is needed to determine its safety and effectiveness across the population of people with MS. Impact Traditional physical therapist interventions for people with MS have been shown to be beneficial; however, their usefulness has been limited by fatigue. A growing body of literature has demonstrated the effects of a BFR/LIRT program on strength and other measures of physical function in healthy populations and those with chronic disease. This case report adds missing information to the existing literature and suggests directions for research on the effectiveness of BFR/LIRT in people with primary progressive MS.


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