scholarly journals Extensive Intracranial Calcification in A Case of Hypoparathyroidism Which Presented With Generalized Tonic-clonic Seizure: A Case Report

2021 ◽  
Author(s):  
Maryam Karimi Fard ◽  
Mehdi Kafi
Keyword(s):  
Parathyroid Hormone ◽  
Ct Scan ◽  
Clonic Seizure ◽  
Tonic Clonic Seizure ◽  
Intracranial Calcification ◽  
Increased Intracranial Pressure ◽  
Parietal Lobes ◽  
Brain Ct Scan ◽  
Laboratory Investigations

Hypoparathyroidism is an endocrine disorder that can be congenital or acquired. Generally, hypoparathyroidism is characterized by hypocalcemia, hyperphosphatemia, and low or abnormal levels of Parathyroid Hormone (PTH). It can be asymptomatic or symptomatic. The symptoms include seizures, paresthesia, depression, psychosis, extrapyramidal manifestations, and increased intracranial pressure. In this case study, we reported a 40-yearold male patient who was admitted to the emergency department with generalized tonicclonic movements and urine incontinency. Laboratory investigations revealed hypocalcemia, hyperphosphatemia, and low parathyroid hormone levels and in paraclinical studies, including Electroencephalography (EEG) and brain CT-scan, despite normal EEG, extensive intracranial calcification involving the basal ganglia, thalamus, white matter of the cerebral hemispheres, and subcortical area of the frontal and parietal lobes were observed on CT-scan.

scholarly journals AN ELDERLY PATIENT WITH BILATERAL INTRACRANIAL CALCIFICATION AND SEIZURE

2019 ◽  
Vol 8 (1S) ◽  
pp. 74
Author(s):  
Marina Anggun Sari ◽  
Meiti Frida ◽  
Basjiruddin Ahmad
Keyword(s):  
Elderly Patient ◽  
Ct Scan ◽  
Intracranial Calcification ◽  
Brain Ct ◽  
Brain Ct Scan

Gangguan neurologis terkait usia seperti gangguan serebrovaskular dan neurodegeneratif merupakan faktor etiologi yang paling umum untuk kejang pada orang tua. Sindrom Fahr merupakan gangguan neurodegeneratif yang jarang terjadi, ditandai dengan deposit kalsium simetris pada kedua hemisfer otak, kebanyakan kasus muncul dengan gejala ekstrapiramidal. Seorang pasien wanita usia 64 tahun dirawat dengan kejang umum tonik klonik 12 jam sebelum masuk rumah sakit. Pasien memiliki riwayat kejang 1 bulan sebelumnya, tetapi tidak mengkonsumsi obat-obatan. Karena kekakuan pada semua ekstremitas, gerakan yang menjadi lambat, dan perubahan perilaku, pasien lebih sering berbaring di tempat tidur dengan ketergantungan penuh pada aktivitas sehari-hari sejak 1 tahun yang lalu. Pasien memiliki riwayat operasi gondok 30 tahun yang lalu. Pada Brain CT Scan didapatkan kalsifikasi intrakranial bilateral di ganglia basal, periventrikel, subkortikal, serebelum tanpa perifokal edema, dengan kadar kalsium darah yang rendah (3,6 mg/dl) dan kadar PTH yang sangat rendah (1,55 pg/ml) yang menunjukkan sindrom Fahr. Pasien mendapatkan terapi antikonvulsan, suplemen kalsium dan calcitriol. Sindrom Fahr harus dipertimbangkan pada pasien dengan manifestasi kejang yang berhubungan dengan kalsifikasi intrakranial, meskipun kasus ini jarang terjadi.

scholarly journals Relevance of early intervention in Fahr’s disease: understanding through a case study

2019 ◽  
Vol 32 (1) ◽  
pp. e100021
Author(s):  
Jamshed Ahmad ◽  
Bandna Gupta ◽  
Sujita Kumar Kar
Keyword(s):  
Clonic Seizure ◽  
Intracranial Calcification ◽  
Neurological Deficits ◽  
Review Of Literature ◽  
Fahr’S Disease ◽  
Fahr's Disease ◽  
Neuronal Tissues ◽  
Management Priorities ◽  
Disease Understanding

Intracranial calcification may result from disturbances in calcium metabolism. It often remains asymptomatic, but may present with symptoms like seizure and neurological deficits. Correction of the underlying metabolic disturbance before damage of neuronal tissues due to intracranial calcification may be useful in preventing irreversible neurological deficits. This window period may be the crucial period that needs a thorough clinical evaluation and urgent intervention. We highlight the case of an adult woman with Fahr’s disease presented with generalised tonic-clonic seizure. The management priorities were also discussed along with review of literature.

scholarly journals ctDNA Clearance and Radiographic Resolution of Disease in Response to Dual Checkpoint Inhibition in Metastatic Microsatellite Stable Colorectal Cancer with a High Tumor Mutation Burden

2021 ◽  
pp. 849-853
Author(s):  
Charles J. Schneider ◽  
Michael Krainock ◽  
Allyson Koyen Malashevich ◽  
Meenakshi Malhotra ◽  
Perry Olshan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Ct Scan ◽  
Circulating Tumor Dna ◽  
Therapeutic Benefit ◽  
Tumor Mutation Burden ◽  
Early Treatment Response ◽  
Mutation Burden ◽  
Disease Present

Immunotherapy (IO) has increasingly been demonstrated to provide therapeutic benefit to patients with metastatic colorectal cancer (mCRC). However, only a subset of mCRC tumors respond to IO. Monitoring response with tumor biomarkers like carcinoembryonic antigen (CEA) has been challenging in patients with microsatellite stable (MSS) mCRC due to low expression of CEA (CEA/lo). Noninvasive blood-based biomarkers such as circulating tumor DNA (ctDNA) can inform early treatment response and augment radiographic monitoring. We describe a case study of a patient with chemotherapy-refractory CEA/lo MSS mCRC, with metastatic disease present in a cardiophrenic lymph node. The patient was given 2 cycles of combination IO (ipilimumab/nivolumab). Response was monitored by ctDNA using a multiplex PCR next-generation sequencing assay, CEA, and CT scan. After IO administration, ctDNA levels rapidly declined, becoming undetectable. This was concurrent with radiographic resolution of the lymph node metastasis. Serial monitoring of CEA during this same period was uninformative, with no significant changes observed. Significant decline in ctDNA identified metastatic response to IO in a patient with CEA/lo, MSS mCRC and was concurrently validated by CT scan. This case study provides evidence that ctDNA can be used as a prospective surrogate for radiographic tumor response.

Mutational analysis of SCN2B, SCN3B and SCN4B in a large Chinese Han family with generalized tonic–clonic seizure

2010 ◽  
Vol 31 (5) ◽  
pp. 675-677 ◽  
Author(s):  
Yang Lu ◽  
Weihua Yu ◽  
Zhiqin Xi ◽  
Zheng Xiao ◽  
Xiaoqin Kou ◽  
...  
Keyword(s):  
Mutational Analysis ◽  
Clonic Seizure ◽  
Tonic Clonic Seizure ◽  
Chinese Han

scholarly journals The utility of brain CT scan modality in the management of dizziness at the emergency department: A retrospective single-center study

2021 ◽  
pp. 102220
Author(s):  
Khaled Z. Alawneh ◽  
Liqaa A. Raffee ◽  
Ahmad A. Oqlat ◽  
Ammar A. Oglat ◽  
Majdi Al Qawasmeh ◽  
...  
Keyword(s):  
Emergency Department ◽  
Ct Scan ◽  
Single Center ◽  
Brain Ct ◽  
Single Center Study ◽  
Brain Ct Scan ◽  
Center Study

scholarly journals Ascending Tonic Clonic Seizure Syndrome after Percutaneous Vertebroplasty

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Guido Zarattini ◽  
Adam Farrier ◽  
Federico Sibona
Keyword(s):  
Percutaneous Vertebroplasty ◽  
Rare Complication ◽  
Cement Leakage ◽  
Clonic Seizure ◽  
Tonic Clonic Seizure ◽  
Leg Pain ◽  
Compression Fractures ◽  
First Case ◽  
Seizure Syndrome ◽  
Osteoporotic Compression Fractures

Background Context. Cement leakage is not a rare complication of vertebroplasty, but ascending tonic clonic seizure syndrome is exceptionally rare. We herein report the first case to our knowledge of this complication related to vertebroplasty.Purpose. We herein report the first case of ascending tonic clonic seizure syndrome following epidural cement leakage after percutaneous vertebroplasty in a patient with multiple osteoporotic compression fractures.Study Design. Case report.Methods. A 64-year-old woman with T8, T10, L2, and L4 osteoporotic compression fractures underwent percutaneous vertebroplasty using polymethylmethacrylate. 40 minutes after the procedure the patient started suffering back and leg pain, having repetitive myoclonic jerks lasting 15 seconds of the lower extremities, spasm of the back, dyspnea, sinus tachycardia, hypoxemia, and metabolic acidosis.Results. The patient recovered completely due to a combination of early effective resuscitation and considered definitive management.Conclusions. Percutaneous vertebroplasty with polymethylmethacrylate is relatively safe but has few dangerous complications, which should be prevented by a meticulous technique and excellent image quality.

scholarly journals Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic–clonic seizure model in mice

2018 ◽  
Vol 126 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Katarzyna M. Sawicka ◽  
Agnieszka Wawryniuk ◽  
Jadwiga Daniluk ◽  
Sławomir Karwan ◽  
Magdalena Florek-Łuszczki ◽  
...  
Keyword(s):  
Antiepileptic Drugs ◽  
Antiarrhythmic Drug ◽  
Clonic Seizure ◽  
Tonic Clonic Seizure ◽  
Class Iii ◽  
Class Iii Antiarrhythmic Drug ◽  
Seizure Model

scholarly journals Factors influencing the duration of generalized tonic–clonic seizure

Seizure ◽  
2016 ◽  
Vol 34 ◽  
pp. 44-47 ◽  
Author(s):  
Sipei Pan ◽  
Fang Wang ◽  
Jing Wang ◽  
Xiang Li ◽  
Xingzhou Liu
Keyword(s):  
Clonic Seizure ◽  
Tonic Clonic Seizure ◽  
Factors Influencing

scholarly journals Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats

2019 ◽  
Vol 65 (9) ◽  
pp. 1188-1192
Author(s):  
Erkan Kilinc ◽  
Handan Gunes
Keyword(s):  
Interleukin 1 ◽  
Plasma Concentrations ◽  
Onset Time ◽  
Epileptic Seizures ◽  
Clonic Seizure ◽  
Tonic Clonic Seizure ◽  
Interleukin 1 Beta ◽  
Calcitonin Gene ◽  
Epilepsy Treatment ◽  
Dual Action

SUMMARY OBJECTIVE We aimed to explore the effects of neuropeptides ghrelin, obestatin, and vasoactive intestinal peptide (VIP) on seizures and plasma concentrations of neuroinflammation biomarkers including calcitonin gene-related peptide (CGRP), substance-P (SP), and interleukin-1 beta (IL-1β) in pentylenetetrazol-induced seizures in rats. METHODS Ghrelin (80 µg/kg), obestatin (1 µg/kg), VIP (25 ng/kg) or saline were administered to rats intraperitoneally 30 min before pentylenetetrazole (PTZ, 50 mg/kg) injections. Stages of epileptic seizures were evaluated by Racine’s scale, and plasma CGRP, SP, and IL-1β concentrations were measured using ELISA. RESULTS Both obestatin and VIP shortened onset-time of generalized tonic-clonic seizure, respectively, moreover VIP also shortened the onset-time of first myoclonic-jerk induced by PTZ. While PTZ increased plasma CGRP, SP and IL-1β concentrations, ghrelin reduced the increases evoked by PTZ. While VIP further increased PTZ-evoked CGRP levels, it diminished IL-1β concentrations. However, obestatin did not change CGRP, SP, and IL-1β concentrations. CONCLUSION Our results suggest that ghrelin acts as an anticonvulsant, obestatin acts as a proconvulsant, and VIP has dual action on epilepsy. Receptors of those neuropeptides may be promising targets for epilepsy treatment.

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