scholarly journals Corrigendum to: “The effect of Phoenix dactylifera pollen on the expression of NRF2, SOD2, CAT, and GPX4 genes, and sperm parameters of fertile and infertile men: A controlled clinical trial” [Int J Reprod BioMed 2021; 19: 545-558]"

2021 ◽  
pp. 752
Author(s):  
Soghra Fallahi ◽  
Minoo Rajaei ◽  
Mohammad Javad Hesam ◽  
Mohsen Koolivand ◽  
Kianoosh Malekzadeh
Keyword(s):  
Clinical Trial ◽  
Phoenix Dactylifera ◽  
Sperm Parameters ◽  
Controlled Clinical Trial ◽  
Infertile Men

This article is a Corrigendum to: “The effect of Phoenix dactylifera pollen on the expression of NRF2, SOD2, CAT, and GPX4 genes, and sperm parameters of fertile and infertile men: A controlled clinical trial” [Int J Reprod BioMed 2021; 19: 545-558]". Please download the PDF or view the article HTML.

scholarly journals The effect of Phoenix dactylifera pollen on the expression of NRF2, SOD2, CAT, and GPX4 genes, and sperm parameters of fertile and infertile men: A controlled clinical trial

2021 ◽  
Author(s):  
Soghra Fallahi ◽  
Minoo Rajaei ◽  
Mohammad Javad Hesam ◽  
Mohsen Koolivand ◽  
Kianoosh Malekzadeh
Keyword(s):  
Clinical Trial ◽  
Male Infertility ◽  
Mrna Expression ◽  
Phoenix Dactylifera ◽  
Sperm Parameters ◽  
Controlled Clinical Trial ◽  
Antioxidant Genes ◽  
Expression Levels ◽  
Infertile Men ◽  
Mrna Expression Levels

Background: Oxidative stress is caused by the imbalance occurring between the creation and clearance of the reactive oxygen species (ROS), which is responsible for 30–40% of male infertility. The positive impact of phoenix dactylifera pollen (Date palm pollen, DPP) on the improvement of sperm parameters has been well documented in animal models. Objective: For evaluating the effect(s) of DPP on sperm parameters, ROS levels, expression of antioxidant genes, and activity of antioxidant enzymes of infertile men. Materials and Methods: In this controlled clinical trial, a total of 60 male case with infertility and 20 normospermic fertile men were recruited. Before and after the treatment with DPP, the case were administered 400 mg/kg of gelatinous capsules daily for 30 consecutive days and semen samples were taken. Quantitative real-time polymerase chain reaction was applied for the evaluation of the mRNA expression levels of Nuclear factor erythroid 2-related factor 2(NRF2), superoxide dismutase (SOD2), glutathione peroxidase 4(GPX4), and catalase (CAT) genes. Results: The mRNA expression levels of NRF2, SOD2, GPX4, and CAT (p < 0.05 for all) and significantly increased after treatment with DPP. The increased expressions of all antioxidant genes and enzymes significantly correlated with improvement in semen parameters including count (p = 0.01), motility (p = 0.05), and morphology (p = 0.01) of sperm. A significant correlation between the alteration of SOD2 gene expression and SOD activity, GPX4 and GPX, and CAT were also observed (p = 0.05). Conclusion: DPP can increase the expressions of NRF2, GPX4, SOD2, and CAT genes and also improve the semen quality in infertile men. Key words: DPP, Male infertility, SOD2, NRF2, GPX4, CAT, ROS, Spermatozoa.

scholarly journals The effects of Vitamin D3 supplementation on Spermatogram and endocrine factors in asthenozoospermia infertile men: a randomized, triple blind, placebo-controlled clinical trial

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Leila Maghsoumi-Norouzabad ◽  
Ahmad Zare Javid ◽  
Anahita Mansoori ◽  
Mohammadreza Dadfar ◽  
Amirarsalan Serajian
Keyword(s):  
Clinical Trial ◽  
Sperm Motility ◽  
Vitamin D3 ◽  
Sperm Count ◽  
Demographic Data ◽  
Sperm Parameters ◽  
Sex Hormone Binding Globulin ◽  
Controlled Clinical Trial ◽  
Total Testosterone ◽  
Infertile Men

Abstract Objective Evaluate the effects of vitamin D3 (VD3) on sperm parameters and endocrine markers in infertile men with asthenozoospermia. Materials and methods This randomized, triple-masking, placebo-controlled clinical trial conducted on 86 asthenozoospermia infertile men with serum 25 hydroxy vitamin D3 (25(OH)VD3) < 30 ng/ml in the infertility clinic of Ahvaz Jahad daneshgahi, Iran. Patients were randomly allocated to groups A and B, who received daily 4000 IU VD3 and matching placebo respectively for 3 months. Demographic data, dietary intake, physical activity, sun exposure, anthropometric indices, serum 25(OH)VD3, luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), estradiol (E2),, sex hormone-binding globulin (SHBG), free androgen index (FAI = T/SHBG. 100), T/LH and T/E2 ratios, prolactin (PRO), parathyroid hormone (PTH), osteocalcin (OCN), phosphorus and sperm parameters were assessed. Results Three months VD3 supplementation with 4000 IU/day had no significant effects body weight, body mass index (BMI), waist circumference (WC), body fat (BF), serum, OCN, LH, FSH, T, E2, SHBG, PRO, T/E2 ratio, FAI, semen volume, sperm count and normal sperm morphology. It increases serum 25(OH)VD3, PTH and phosphorus and seminal and serum calcium, T/LH ratio and total and progressive sperm motility and decreased significantly compared to the baseline and placebo group. Conclusion VD3 supplementation may affect sperm motility in men with asthenozoospermia and serum 25(OH)VD3 < 30 ng/ml. Trial registration Iran Clinical Trials Registry, ID: IRCT20151128025274N4, registered on 28 March 2018, URL of trial registry record: https://www.irct.ir/trial/29983

scholarly journals Effect of letrozole on spermogram parameters and hormonal profile in infertile men: A clinical trial study

2019 ◽  
Vol 53 (4) ◽  
pp. 231-236
Author(s):  
Sepideh Peivandi ◽  
Hamed Jafarpour ◽  
Mina Abbaspour ◽  
Aghdas Ebadi
Keyword(s):  
Clinical Trial ◽  
Aromatase Inhibitor ◽  
Sperm Concentration ◽  
Serum Testosterone ◽  
Sperm Parameters ◽  
Hormonal Profile ◽  
Sperm Analysis ◽  
Infertile Men ◽  
Letrozole Treatment ◽  
Quasi Experimental

AbstractObjective. There is no reliable treatment for men with idiopathic infertility, but the relationship between severe sperm production and the ratio of estrogen to testosterone levels has been shown. Aromatase is an enzyme that plays an important role in converting testosterone to estradiol and androstenedione to estrogen. Aromatase inhibitors can increase testosterone and androgen production without increasing the amount of estrogen in circulation. The aim of this study was to evaluate the effect of aromatase inhibitor letrozole on the male infertility.Method. This pre- and post-quasi-experimental clinical trial was carried out on 41 men with an infertility diagnosis. The basic hormonal profile included FSH, LH, testosterone, and estradiol. The ratio of testosterone to serum estradiol was also calculated and recorded. The sperm analysis was performed before the treatment and the seminal parameters were evaluated and recorded. Patients were then treated with letrozole 2.5 mg daily for 4 months. At the end of 4th months, the hormonal profile was studied and seminal analysis performed and recorded.Results. The levels of FSH, LH, testosterone, and estradiol, and the ratio of testosterone to estradiol increased significantly after letrozole treatment. The sperm concentration, sperm motility, and sperm forward motion significantly increased after letrozole treatment. Sperm morphology only lightly altered.Conclusion. The ratio of testosterone to estradiol levels in infertile men treated with aromatase inhibitor improved and caused changes in sperm parameters. Letrozole may be used to improve sperm parameters in infertile men with low serum testosterone to estradiol ratio.

Controlled Clinical Trial of Arginine for Infertile Men with Oligozoospermia

1978 ◽  
Vol 50 (1) ◽  
pp. 47-50 ◽  
Author(s):  
J. P. PRYOR ◽  
J. P. BLANDY ◽  
P. EVANS ◽  
D. M. CHAPUT DE SAINTONGE ◽  
M. USHERWOOD
Keyword(s):  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Infertile Men

Comparison of the effect of Ceratonia siliqua L. fruit oral capsule and vitamin E on semen parameters in men with idiopathic infertility: a triple-blind randomized controlled clinical trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sima Sanagoo ◽  
Azizeh Farshbaf-Khalili ◽  
Parina Asgharian ◽  
Samad Hazhir ◽  
Behnaz Sadeghzadeh Oskouei
Keyword(s):  
Vitamin E ◽  
Sperm Motility ◽  
Sperm Count ◽  
Sperm Parameters ◽  
Semen Parameters ◽  
Controlled Clinical Trial ◽  
Ceratonia Siliqua ◽  
Randomized Controlled ◽  
Infertile Men ◽  
The Mean

Abstract Objectives To compare the effect of oral Ceratonia siliqua (Carob) and vitamin E on sperm parameters in idiopathic infertile men. Methods In this triple-blind randomized controlled trial study, fifty 20–45-year-old infertile men with idiopathic abnormal sperm parameters were selected among men referring to the infertility clinic of Al Zahra-Iran Hospital, and randomly allocated into two groups. The first group received Carob capsules, 500 mg, and the second group received vitamin E capsules three times a day for 90 days. The primary outcomes of this study were the sperm parameters (count, motility, and morphology). Results After the intervention, the mean of sperm count increased from 49.08 to 60.22 million/mL in the carob vs. it increased from 47.64 to 58.88 million/mL in the vitamin E group (adjusted mean difference (aMD)=1.124 million/ml, 95% CI: −12.892 to 15.141). The mean sperm motility increased from 45.90 to 52.90% in the carob group but decreased from 55.23 to 38.10% in the vitamin E group (aMD=17.22%, 95% CI: 8.53 to 25.92). The mean sperms with normal morphology increased from 11.52 to 67.05% in the carob, and from 10.20 to 77.47% in the vitamin E group (aMD=−10.88%, 95% CI: −22.30 to 0.536). There was no serious side effect during the treatment course. Conclusions Taking 1,500 mg oral dose of Carob capsule per day for 90 days improved sperm motility but had no significant effect for improving morphology and count comparing to vitamin E capsule.

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