scholarly journals Concomitant Staphylococcus aureus and Burkholderia pseudomallei infection causing multifocal osteomyelitis a rare presentation of melioidosis in an uncontrolled diabetic host- case series

2019 ◽  
Vol 7 (7) ◽  
Author(s):  
Sharandeep Singh Saluja ◽  
Keyword(s):  
Staphylococcus Aureus ◽  
Burkholderia Pseudomallei ◽  
Case Series ◽  
Rare Presentation ◽  
Multifocal Osteomyelitis

scholarly journals Osteomyelitis in Immunocompromised children and neonates, a case series

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bryan Foong ◽  
Kenneth Pak Leung Wong ◽  
Carolin Joseph Jeyanthi ◽  
Jiahui Li ◽  
Kevin Boon Leong Lim ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Staphylococcus Aureus ◽  
Palliative Care ◽  
Stenotrophomonas Maltophilia ◽  
Burkholderia Pseudomallei ◽  
Bone Growth ◽  
Case Series ◽  
Immune Recovery ◽  
Prolonged Administration ◽  
Infectious Disease Service

Abstract Background Osteomyelitis in immunocompromised children can present differently from immunocompetent children and can cause devastating sequelae if treated inadequately. We aim to review the aetiology, clinical profile, treatment and outcomes of immunocompromised children with osteomyelitis. Methods Retrospective review of all immunocompromised children aged < 16 years and neonates admitted with osteomyelitis in our hospital between January 2000 and January 2017, and referred to the Paediatric Infectious Disease Service. Results Fourteen patients were identified. There were 10 boys (71%), and the median age at admission was 70.5 months (inter-quartile range: 12.3–135.0 months). Causal organisms included, two were Staphylococcus aureus, two were Mycobacterium bovis (BCG), and one each was Mycobacterium tuberculosis, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Burkholderia pseudomallei and Rhizopus sp. One patient had both Clostridium tertium and Clostridium difficile isolated. Treatment involved appropriate antimicrobials for a duration ranging from 6 weeks to 1 year, and surgery in 11 patients (79%). Wherever possible, the patients received treatment for their underlying immunodeficiency. For outcomes, only three patients (21%) recovered completely. Five patients (36%) had poor bone growth, one patient had recurrent discharge from the bone and one patient had palliative care for underlying osteosarcoma. Conclusions Although uncommon, osteomyelitis in immunocompromised children and neonates can be caused by unusual pathogens, and can occur with devastating effects. Treatment involves prolonged administration of antibiotics and surgery. Immune recovery also seems to be an important factor in bone healing.

scholarly journals Melioidosis: A Rare Cause of Liver Abscess

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Peter Franz M. San Martin ◽  
Catherine S. C. Teh ◽  
Ma. Amornetta J. Casupang
Keyword(s):  
Liver Abscess ◽  
Burkholderia Pseudomallei ◽  
Abdominal Ultrasound ◽  
Open Drainage ◽  
High Grade Fever ◽  
Rare Presentation ◽  
Culture Studies ◽  
Moderate Growth ◽  
Male Farmer ◽  
History Of

Case Presentation. This is a case of a 44-year-old male, farmer, known to be diabetic, presenting with two-week history of vague abdominal pain associated with high grade fever. Abdominal CT scan showed localized liver abscess at segment 8 measuring 7.5 × 6.8 × 6.1 cm. Patient subsequently underwent laparoscopic ultrasound guided pigtail insertion for drainage of abscess. Culture studies showed moderate growth ofBurkholderia pseudomalleiin which the patient completed seven days of IV Meropenem. On follow-up after 12 weeks of oral Sulfamethoxazole/Trimethoprim, taken twice a day, the patient remained asymptomatic with no residual findings based on the abdominal ultrasound.Discussion. Diagnosis of melioidosis, a known “great masquerader,” relies heavily on culture studies. Consensus with regard to the management of liver abscess caused byBurkholderia pseudomalleihas not yet been established due to the rarity of cases. Surgical intervention through either a percutaneous or open drainage has shown good outcomes compared to IV antibiotics alone. In Philippines, the possibility of underreporting is highly plausible. This write-up serves not only to report a rare presentation of melioidosis but also to add to the number of cases reported in the country, possibly indicative of disease emergence.

scholarly journals Case series of Community Acquired Methicillin Resistant Staphylococcus Aureus

2018 ◽  
Vol 73 ◽  
pp. 159
Author(s):  
S. Lupo ◽  
N. Tamagnone ◽  
M.S. Rodriguez ◽  
A. Co ◽  
M. Vera Blanch ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Case Series ◽  
Methicillin Resistant

scholarly journals Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series

2020 ◽  
Vol 12 (3) ◽  
pp. 61-69
Author(s):  
Beatriz Prista-Leão ◽  
Isabel Abreu ◽  
Raquel Duro ◽  
André Silva-Pinto ◽  
Filipa Ceia ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistance ◽  
Case Series ◽  
Adult Males ◽  
Gene Search ◽  
Physician Awareness ◽  
Travel Abroad ◽  
Adequate Management ◽  
Panton Valentine Leukocidin ◽  
Valentine Leukocidin

Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) is associated with relapsing multifocal skin and soft tissue infections (SSTI), necrotizing pneumonia (NP) and severe musculoskeletal infections. Epidemiology is underknown and underdiagnosis is likely. Recent travel abroad, case clustering and relapsing disease are often reported. We reviewed all cases of PVL-SA infection diagnosed at our center, and found 21 cases over a 43-month period. Most patients were adult males, had relevant travel history, reported recurrent disease and presented with SSTI. Etiologic diagnosis took up to five years; meanwhile, 42% of patients had antibiotic treatments. Draining procedures were required in 43% of patients and intensive care support in 19%. All patients recovered. Methicillin-resistance prevalence was 24%. Only 2/13 decolonized patients had posterior relapsing SSTI, both with likely infected contacts. PVL-SA infection’s severity and impact are clear, even in small case series as ours. Physician awareness and active PVL-gene search are crucial for an adequate management.

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