Autologous whole blood versus corticosteroid local injection in treatment of plantar fasciitis

Background: Plantar fasciitis represents painful inflammatory process of plantar fascia with pain beneath the heel. The disease is frustrating for both the patient and the physician as the etiology is unknown. Conservative management is the mainstay of treatment. Patients with resistant pain can be treated with local injections. In this study we evaluated the effectiveness of autologous whole blood injection for treatment of chronic plantar fasciitis.Methods: The study was conducted on 55 patients (males=25, females=30) with chronic heel pain for more than 6 months and failed conservative treatment. After proper clinical evaluation and diagnosis, autologous whole blood was injected on medial aspect of heel at the most tender point. Visual analog score was noted before injection and at 3 and 6 months of follow-up.Results: Mean preprocedure visual analog score was 8.2 (range=4-10), which reduced to a mean of 4.5 (range=0-9) at 3 month follow-up and 3.3 (range 0-9) at 6 month follow-up. The reduction in VAS score was statistically significant (p<0.001). No complications occurred in our series.Conclusions: Autologous whole blood injections appear to be cost-effective for treatment of resistant plantar fasciitis with no serious side effects.

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Preemptive intravenous iron therapy versus autologous whole blood therapy for early postoperative hemoglobin level in patients undergoing bimaxillary orthognathic surgery: a prospective randomized noninferiority trial

BMC Oral Health ◽

10.1186/s12903-020-01359-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Min Suk Chae ◽

Mihyun Lee ◽

Min Ho Choi ◽

Je Uk Park ◽

Misun Park ◽

...

Keyword(s):

Blood Transfusion ◽

Blood Group ◽

Whole Blood ◽

Orthognathic Surgery ◽

Hemoglobin Level ◽

Iron Therapy ◽

Iron Group ◽

Autologous Whole Blood ◽

Bimaxillary Orthognathic Surgery ◽

Iv Iron

Abstract Background Previous studies have reported the efficacy and safety of intravenous (IV) iron therapy during the perioperative period as an alternative and adjunct to allogeneic blood transfusion. Preemptive IV iron therapy provides noninferior hemoglobin levels on postoperative day (POD) 1 compared to autologous whole blood therapy (AWBT) in healthy patients who had undergone bimaxillary orthognathic surgery. Methods This was a prospective, patient-randomized, noninferiority trial. After excluding 2 patients, 64 patients were divided into two groups: the IV iron therapy group (patients received IV iron infusion 4 weeks before surgery; n = 32) and the AWBT group (2 units of autologous whole blood were collected 4 and 2 weeks before surgery; n = 32). The primary outcome was hemoglobin level on POD 1 and the prespecified noninferiority limit was − 1 g/dL. Results Baseline data were comparable, including hemoglobin and iron levels, between the two groups. Immediately before surgery, the levels of hemoglobin, iron, and ferritin were higher in the IV iron group than in the AWBT group. The mean treatment difference (iron group—whole blood group) in hemoglobin level on POD 1 between the two groups was 0.09 (95% CI = − 0.83 to 1.0). As the lower limit of the 95% CI (− 0.83) was higher than the prespecified noninferiority margin (δ = − 1), noninferiority was established. On POD 2, the hemoglobin level became lower in the iron group, which eventually led to greater requirement of allogeneic blood transfusion compared to the whole blood group. However, the iron group did not require allogeneic blood transfusion during or early after surgery, and the whole blood group showed continuously higher incidence of overt iron deficiency compared to the iron group. Conclusion As collection of autologous whole blood caused overt iron loss and anemia before surgery and intraoperative transfusion of whole blood was not able to prevent the occurrence of persistent iron deficiency after surgery, IV iron therapy was found to have potential benefits for iron homeostasis and subsequent erythropoiesis in healthy patients early after bimaxillary orthognathic surgery. Trial registration: Clinical Research Information Service, Republic of Korea, approval number: KCT0003680 on March 27, 2019. https://cris.nih.go.kr/cris/search/search_result_st01_kren.jsp?seq=15769&sLeft=2&ltype=my&rtype=my.

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Effect of Platelet-Rich Plasma (PRP) versus Autologous Whole Blood on Pain and Function Improvement in Tennis Elbow: A Randomized Clinical Trial

Pain Research and Treatment ◽

10.1155/2014/191525 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 8

Author(s):

Seyed Ahmad Raeissadat ◽

Leyla Sedighipour ◽

Seyed Mansoor Rayegani ◽

Mohammad Hasan Bahrami ◽

Masume Bayat ◽

...

Keyword(s):

Whole Blood ◽

Tennis Elbow ◽

Platelet Rich Plasma ◽

Autologous Blood ◽

Pressure Pain Threshold ◽

Lateral Epicondylitis ◽

Autologous Whole Blood ◽

Significant Difference ◽

Group 2 ◽

And Function

Background. Autologous whole blood and platelet-rich plasma (PRP) have been both suggested to treat chronic tennis elbow. The aim of the present study was to compare the effects of PRP versus autologous whole blood local injection in chronic tennis elbow. Methods. Forty patients with tennis elbow were randomly divided into 2 groups. Group 1 was treated with a single injection of 2 mL of autologous PRP and group 2 with 2 mL of autologous blood. Tennis elbow strap, stretching, and strengthening exercises were administered for both groups during a 2-month followup. Pain and functional improvements were assessed using visual analog scale (VAS), modified Mayo Clinic performance index for the elbow, and pressure pain threshold (PPT) at 0, 4, and 8 weeks. Results. All pain and functional variables including VAS, PPT, and Mayo scores improved significantly in both groups 4 weeks after injection. No statistically significant difference was noted between groups regarding pain scores in 4-week follow-up examination (P>0.05). At 8-week reevaluations, VAS and Mayo scores improved only in PRP group (P<0.05). Conclusion. PRP and autologous whole blood injections are both effective to treat chronic lateral epicondylitis. PRP might be slightly superior in 8-week followup. However, further studies are suggested to get definite conclusion.

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Preemptive intravenous iron therapy versus autologous whole blood therapy for early postoperative hemoglobin level in patients undergoing bimaxillary orthognathic surgery: A prospective randomized noninferiority trial

10.21203/rs.3.rs-64923/v2 ◽

2020 ◽

Author(s):

Min Suk Chae ◽

Mihyun Lee ◽

Min Ho Choi ◽

Je Uk Park ◽

Misun Park ◽

...

Keyword(s):

Blood Transfusion ◽

Blood Group ◽

Whole Blood ◽

Orthognathic Surgery ◽

Hemoglobin Level ◽

Iron Therapy ◽

Iron Group ◽

Autologous Whole Blood ◽

Bimaxillary Orthognathic Surgery ◽

Iv Iron

Abstract Background: Previous studies have reported the efficacy and safety of intravenous (IV) iron therapy during the perioperative period as an alternative and adjunct to allogeneic blood transfusion. Preemptive IV iron therapy provides noninferior hemoglobin levels on postoperative day (POD) 1 compared to autologous whole blood therapy (AWBT) in healthy patients who had undergone bimaxillary orthognathic surgery.Methods: This was a prospective, patient-randomized, noninferiority trial. After excluding 2 patients, 64 patients were divided into two groups: the IV iron therapy group (patients received IV iron infusion 4 weeks before surgery; n = 32) and the AWBT group (2 units of autologous whole blood were collected 4 and 2 weeks before surgery; n = 32). The primary outcome was hemoglobin level on POD 1 and the prespecified noninferiority limit was –1 g/dL. Results: Baseline data were comparable, including hemoglobin and iron levels, between the two groups. Immediately before surgery, the levels of hemoglobin, iron, and ferritin were higher in the IV iron group than in the AWBT group. The mean treatment difference (iron group – whole blood group) in hemoglobin level on POD 1 between the two groups was 0.09 (95% CI = –0.83 to 1.0). As the lower limit of the 95% CI (–0.83) was higher than the prespecified noninferiority margin (δ = –1), noninferiority was established. On POD 2, the hemoglobin level became lower in the iron group, which eventually led to greater requirement of allogeneic blood transfusion compared to the whole blood group. However, the iron group did not require allogeneic blood transfusion during or early after surgery, and the whole blood group showed continuously higher incidence of overt iron deficiency compared to the iron group. Conclusion: As collection of autologous whole blood caused overt iron loss and anemia before surgery and intraoperative transfusion of whole blood was not able to prevent the occurrence of persistent iron deficiency after surgery, IV iron therapy was found to have potential benefits for iron homeostasis and subsequent erythropoiesis in healthy patients early after bimaxillary orthognathic surgery.Trial registration: Clinical Research Information Service, Republic of Korea, approval number: KCT0003680 on March 27, 2019https://cris.nih.go.kr/cris/search/search_result_st01_kren.jsp?seq=15769&sLeft=2&ltype=my&rtype=my

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Storage-related changes in autologous whole blood and irradiated allogeneic red blood cells and their ex vivo effects on deformability, indices, and density of circulating erythrocytes in patients undergoing cardiac surgery with cardiopulmonary bypass

Journal of Cardiothoracic and Vascular Anesthesia ◽

10.1053/j.jvca.2021.06.016 ◽

2021 ◽

Author(s):

Junko Ichikawa ◽

Ichiro Koshino ◽

Nobuto Arashiki ◽

Fumio Nakamura ◽

Makiko Komori

Keyword(s):

Cardiac Surgery ◽

Cardiopulmonary Bypass ◽

Red Blood Cells ◽

Whole Blood ◽

Blood Cells ◽

Ex Vivo ◽

Autologous Whole Blood

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Systemic and microcirculatory effects of autologous whole blood resuscitation in severe hemorrhagic shock

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1999.276.6.h2035 ◽

1999 ◽

Vol 276 (6) ◽

pp. H2035-H2043 ◽

Cited By ~ 16

Author(s):

Heinz Kerger ◽

Klaus F. Waschke ◽

Klaus V. Ackern ◽

Amy G. Tsai ◽

Marcos Intaglietta

Keyword(s):

Metabolic Acidosis ◽

Hemorrhagic Shock ◽

Whole Blood ◽

Tissue Perfusion ◽

Capillary Density ◽

Shed Blood ◽

Syrian Golden Hamsters ◽

Autologous Whole Blood ◽

Significant Impairment ◽

Main Determinants

Systemic and microcirculatory effects of autologous whole blood resuscitation after 4-h hemorrhagic shock with a mean arterial pressure (MAP) level of 40 mmHg were investigated in 63 conscious Syrian golden hamsters. Microcirculation of skeletal skin muscle and subcutaneous connective tissue was visualized in a dorsal skinfold. Shed blood was retransfused within 30 min after 4 h. Animals were grouped into survivors in good (SG) and poor condition (SP) and nonsurvivors (NS) according to 24-h outcome after resuscitation and studied before shock, during shock (60, 120, and 240 min), and 30 min and 24 h after resuscitation. Microvascular and interstitial[Formula: see text] values were determined by phosphorescence decay. Shock caused a significant increase of arterial[Formula: see text] and decrease of[Formula: see text], pH, and base excess. In the microcirculation, there was a significant decrease in blood flow (Q˙B), functional capillary density (FCD; capillaries with red blood cell flow), and interstitial [Formula: see text][1.8 ± 0.8 mmHg (SG), 1.3 ± 1.3 mmHg (SP), and 0.9 ± 1.1 mmHg (NS) vs. 23.0 ± 6.1 mmHg at control]. Blood resuscitation caused immediate MAP recompensation in all animals, whereas metabolic acidosis, hyperventilation, and a significant interstitial [Formula: see text] decrease (40–60% of control) persisted. In NS (44.4% of the animals), systemic and microcirculatory alterations were significantly more severe both in shock and after resuscitation than in survivors. Whereas in SG (31.8% of the animals) there was only a slight (15–30%) but still significant impairment of microscopic tissue perfusion (Q˙B, FCD) and oxygenation at 24 h, SP (23.8% of the animals) showed severe metabolic acidosis and substantial decreases (≥50%) of FCD and interstitial[Formula: see text]. FCD, interstitial[Formula: see text], and metabolic state were the main determinants of shock outcome.

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