scholarly journals Effects on the Cost and Utilization of Proton Pump Inhibitors From Adding Over-the Counter Omeprazole to Drug Benefit Coverage in a State Employee Health Plan

2004 ◽  
Vol 10 (5) ◽  
pp. 449-455 ◽  
Author(s):  
Brittany N. Harris ◽  
Donna S. West ◽  
Jill Johnson ◽  
Song Hee Hong ◽  
Cindy D. Stowe
Keyword(s):  
Health Plan ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Employee Health ◽  
Drug Benefit ◽  
Over The Counter ◽  
The Cost ◽  
State Employee

scholarly journals ePrescribing: Reducing Costs through In-Class Therapeutic Interchange

2016 ◽  
Vol 07 (04) ◽  
pp. 1168-1181 ◽  
Author(s):  
Shane Stenner ◽  
Rohini Chakravarthy ◽  
Kevin Johnson ◽  
William Miller ◽  
Julie Olson ◽  
...  
Keyword(s):  
Health Plan ◽  
Proton Pump ◽  
Serotonin Receptor ◽  
Cost Savings ◽  
Employee Health ◽  
Prescription Data ◽  
Therapeutic Interchange ◽  
Reducing Costs ◽  
Serotonin Receptor Agonists ◽  
Outpatient Prescriptions

SummaryIntroduction Spending on pharmaceuticals in the US reached $373.9 billion in 2014. Therapeutic interchange offers potential medication cost savings by replacing a prescribed drug for an equally efficacious therapeutic alternative.Methods Hard-stop therapeutic interchange recommendation alerts were developed for four medication classes (HMG-CoA reductase inhibitors, serotonin receptor agonists, intranasal steroid sprays, and proton-pump inhibitors) in an electronic prescription-writing tool for outpatient prescriptions. Using prescription data from January 2012 to June 2015, the Compliance Ratio (CR) was calculated by dividing the number of prescriptions with recommended therapeutic interchange medications by the number of prescriptions with non-recommended medications to measure effectiveness. To explore potential cost savings, prescription data and medication costs were analyzed for the 45,000 Vanderbilt Employee Health Plan members.Results for all medication classes, significant improvements were demonstrated – the CR improved (proton-pump inhibitors 2.8 to 5.32, nasal steroids 2.44 to 8.16, statins 2.06 to 5.51, and serotonin receptor agonists 0.8 to 1.52). Quarterly savings through the four therapeutic interchange interventions combined exceeded $200,000 with an estimated annual savings for the health plan of $800,000, or more than $17 per member.Conclusion A therapeutic interchange clinical decision support tool at the point of prescribing resulted in increased compliance with recommendations for outpatient prescriptions while producing substantial cost savings to the Vanderbilt Employee Health Plan – $17.77 per member per year.Therapeutic interchange rules require rational targeting, appropriate governance, and vigilant content updates.Citation: Stenner SP, Chakravarthy R, Johnson KB, Miller WL, Olson J, Wickizer M, Johnson NN, Ohmer R, Uskavitch DR, Bernard GR, Neal EB, Lehmann CU. eprescribing: reducing costs through in-class therapeutic interchange.

scholarly journals Counting the cost of proton pump inhibitors

Gut ◽  
2001 ◽  
Vol 49 (4) ◽  
pp. 462-463 ◽  
Author(s):  
P MOAYYEDI
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
The Cost

scholarly journals Proton Pump Inhibitors and Pain

2009 ◽  
Vol 6;12 (6;12) ◽  
pp. 1013-1023
Author(s):  
Howard Smith
Keyword(s):  
Iron Deficiency ◽  
Proton Pump Inhibitor ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Direct Evidence ◽  
Iron Absorption ◽  
Syndrome Patient ◽  
Restless Leg Syndrome ◽  
Over The Counter ◽  
Low Serum

There may be a relationship between proton pump inhibitors (PPIs) and iron absorption. PPIs may decrease the amount of iron absorbed gastrointestinally specifically due to alteration of the pH in the duodenum. Restless legs syndrome (RLS) is a sensorimotor disorder that includes an urge to move legs, accompanied or caused by uncomfortable and unpleasant sensations in the legs; the urge to move begins or worsens during periods of rest or inactivity, the urge to move is partially or totally relieved by movement, and the urge is worse or only occurs at night. In the majority of the restless leg syndrome population, the sensation is deep seated, often described as being in the shin bones, and most commonly felt between the knee and ankle. It may be described as a creepy, shock-like, tense, electric, buzzing, itchy, or even numb sensation. A subpopulation of this restless leg syndrome patient population experiences restless leg syndrome associated pain (RLSAP) that has been described as a deep “achy pain.” This pain has not been found to be relieved by many of the typical over the counter analgesics. Often, constant movement of the legs appears to be the only remedy, as these sensations usually appear during periods of rest. Furthermore, there appears to be an association between iron deficiency and those suffering from Restless Leg Syndrome (RLS). The authors theorize that there may be a possible correlation between PPIs and the symptoms (e.g. pain) associated with RLS. The authors propose that PPIs, such as omeprazole, may interfere with iron absorption in certain patients and that a subpopulation of patients who develop significant iron deficiency characterized by low serum ferritin levels while on PPIs may also develop RLS-like symptoms (including RLSAP). While there is no robust direct evidence to support any associations of PPIs and iron deficiency or PPIs associated with RLS-like symptoms (including RLSAP), it is hoped that this manuscript may spark research efforts on this issue. Key words: Proton pump inhibitor (PPI), Restless Leg Syndrome (RLS), iron deficiency, pain, iron absorption, Restless Leg Syndrome Associated Pain (RLSAP)

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