Investigation of mechanisms of action of growth factors of autologous platelet-rich plasma used to treat erectile dysfunction

Urologiia ◽  
2017 ◽  
Vol 4_2017 ◽  
pp. 46-48 ◽  
Author(s):  
M.V. Epifanova Epifanova ◽  
M.E. Chalyi Chalyi ◽  
A.O. Krasnov Krasnov ◽  
◽  
Keyword(s):  
Erectile Dysfunction ◽  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Mechanisms Of Action ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals ROLE OF PLATELET RICH PLASMA IN TREATMENT OF CHRONIC NON-HEALING VENOUS ULCER

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Firdaus A. Dekhaiya ◽  
Jignesh K. Joshi ◽  
Sarav Bamania
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Healing Process ◽  
Venous Ulcer ◽  
Lower Limbs ◽  
Venous Ulcers ◽  
Autologous Platelet Rich Plasma ◽  
Adhesive Proteins ◽  
Autologous Platelet

Introduction: Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the lower limbs. Considering that PRP is a source of growth factors, and consequently has mitogenic, angiogenic, and chemotactic properties, it represents an adjunctive treatment for recalcitrant wounds. Moreover, PRP provides the wound with adhesive proteins, such as fibrinogen, which are important in wound healing. PRP contain more amount of platelets, cytokines and growth factors which are dispersed in a very small amount of plasma which can be prepared from a sample of centrifuged autologous blood. Application of PRP has been reported to be effective in both acute as well as chronic non healing venous ulcers. Aim and Objective: To evaluate the efficacy of autologous platelet rich plasma in the management of chronic venous ulcer. Material and Method: A Prospective study conducted on 100 patients of chronic venous ulcers admitted in Sir T. Hospital Bhavnagar from June 2018 to June 2019 after fulfilled our inclusion and exclusion criteria. PRP then injected intalesionally inside and around the periphery of the wound/ulcer. This process was done once/week for 12 weeks. At every week, the area and volume of ulcer was calculated and photographs were taken. Result: All the patients showed healing of the ulcer with reduction in size of ulcer more than 90% was observed in 72 patients, followed by 80–90% reduction in wound size in 18 patients after the 12 weeks follow-up. Overall, significant reduction in size of ulcer was observed in all the treated patients. Conclusion: Autologous platelet rich plasma (PRP) as an autologous method, it is biocompatible, simple, safe, affordable and less expensive procedure in the treatment of chronic venous ulcers. PRP is found to be useful in improving and enhancing the healing process in chronic venous leg ulcers without any side effect. Keywords:  Venous ulcer, Platelet rich plasma

286 Efficacy of autologous platelet-rich plasma for the treatment of erectile dysfunction

2018 ◽  
Vol 15 (7) ◽  
pp. S238
Author(s):  
M.V. Epifanova ◽  
M.E. Chaliy ◽  
B.R. Gvasalia ◽  
A.M. Repin ◽  
S.A. Artemenko
Keyword(s):  
Erectile Dysfunction ◽  
Platelet Rich Plasma ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals REPARATIVE PROCESSES FEATURES IN TROPHIC ULCERS CAUSED BY DIABETES MELLITUS WITH THE USE OF PLATELET-RICH PLASMA

2020 ◽  
Vol 73 (10) ◽  
pp. 2150-2155
Author(s):  
Igor D. Duzhiy ◽  
Andrii S. Nikolaienko ◽  
Vasyl M. Popadynets ◽  
Oleksandr V. Kravets ◽  
Igor Y. Hresko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factors ◽  
Comparison Group ◽  
Platelet Rich Plasma ◽  
Main Group ◽  
Lower Limbs ◽  
Before And After ◽  
Autologous Platelet Rich Plasma ◽  
Inflammatory Changes ◽  
Autologous Platelet

The aim: Was following: the improvement of the treatment results of the lower limbs ulcers, caused by the diabetes mellitus by using our technique of the platelet-rich plasma application; the study of the features of the morphological and immunohistochemical changes, and the effect of the growth factors of the platelet-rich plasma on the regeneration and healing of the ulcers. Materials and methods: 38 patients with the trophic ulcers of the lower limbs, caused by diabetes mellitus were involved in the study. To assess the morphological features of the reparative processes before and after the treatment with PRP, the histological and immunohystochemical studies of the biopsy specimen of ulcers were carried out. Results: The total epithelialization of the ulcers in the patients from the main group was achieved on 46.5 day, and in the comparison group – 81.7 day. The light and optical study of the specimen of the main group, using the autologous platelet-rich plasma revealed the elimination of the destructive changes and reduction of the mixed-cellular infiltration compared to the patients from the comparison group. The immunohystochemical study revealed the increase of the growth factors receptors. Conclusions: The usage of the autologous platelet-rich plasma in the treatment of the trophic ulcers results in the rapid regeneration by the decrease of the destructive and inflammatory changes as well as the improvement of the vascularization.

Autologous platelet-rich plasma versus readymade growth factors in skin rejuvenation: A split face study

2017 ◽  
Vol 16 (2) ◽  
pp. 258-264 ◽  
Author(s):  
Heba I Gawdat ◽  
Amira M Tawdy ◽  
Rehab A Hegazy ◽  
Mohga M Zakaria ◽  
Ryham S Allam
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Skin Rejuvenation ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Split Face

scholarly journals Evaluation of graft uptake using temporalis fascia and cartilage perichondrium supplemented with autologous platelet rich plasma in tympanoplasty

2021 ◽  
Vol 7 (2) ◽  
pp. 308
Author(s):  
N. R. Ankle ◽  
Rajesh Radhakrishna Havaldar ◽  
Sweta Sinha
Keyword(s):  
Growth Factors ◽  
Mechanical Stability ◽  
Platelet Rich Plasma ◽  
Donor Site ◽  
Chronic Otitis Media ◽  
Temporalis Fascia ◽  
Autologous Platelet Rich Plasma ◽  
Operative Assessment ◽  
Autologous Platelet ◽  
And Cartilage

<p class="abstract"><strong>Background:</strong> Tympanoplasty involves grafting the perforation of the tympanic membrane with materials such as temporalis fascia, cartilage perichondrium, periosteum, vein, fat etc. Both temporalis fascia and cartilage perichondrium are easy to harvest with minimum donor site complications and both have been used extensively in tympanoplasty. Platelet rich plasma aids as an adhesive and supplements healing by providing growth factors. Till date there is scarcity of literature comparing the healing outcome of both cartilage perichondrium and temporalis fascia supplemented with platelet rich plasma. Hence, in this study we are comparing cartilage perichondrium supplemented with platelet rich plasma and temporalis fascia supplemented with platelet rich plasma.  </p><p class="abstract"><strong>Methods:</strong> An observational study involving 60 patients was done. Patients with chronic otitis media were evaluated by otoendoscopy to assess the ear and were categorised into 2 groups which received temporalis fascia and cartilage perichondrium respectively. All cases were supplemented with platelet rich plasma. Post-operative assessment was done by otoendoscopy.   </p><p class="abstract"><strong>Results:</strong> Total 21 patients received temporalis fascia and 39 patients received cartilage perichondrium. At the end of 6 weeks the graft site appeared unhealthy in 6.66% cases who received temporalis fascia and 1.66% in those who received cartilage perichondrium.  </p><p class="abstract"><strong>Conclusions:</strong> We found that cartilage perichondrium supplemented with platelet rich plasma had a better uptake after 6 weeks due to its superior mechanical stability. The results are more rewarding than the use of temporalis fascia with platelet rich plasma.</p>

Use of autologous platelet-rich plasma in trichology

2021 ◽  
pp. 30-32
Author(s):  
A. V. Gismieva
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Promising Treatment ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

The article is of a review nature and contains up-to-date information on the application autologous platelet-rich plasma in trichology. The use of autologous platelet-rich plasma is a promising treatment. The application on this technique is to improve and accelerate the processes caused by the stimulating growth factors contained in platelets.

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