scholarly journals REPARATIVE PROCESSES FEATURES IN TROPHIC ULCERS CAUSED BY DIABETES MELLITUS WITH THE USE OF PLATELET-RICH PLASMA

2020 ◽  
Vol 73 (10) ◽  
pp. 2150-2155
Author(s):  
Igor D. Duzhiy ◽  
Andrii S. Nikolaienko ◽  
Vasyl M. Popadynets ◽  
Oleksandr V. Kravets ◽  
Igor Y. Hresko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factors ◽  
Comparison Group ◽  
Platelet Rich Plasma ◽  
Main Group ◽  
Lower Limbs ◽  
Before And After ◽  
Autologous Platelet Rich Plasma ◽  
Inflammatory Changes ◽  
Autologous Platelet

The aim: Was following: the improvement of the treatment results of the lower limbs ulcers, caused by the diabetes mellitus by using our technique of the platelet-rich plasma application; the study of the features of the morphological and immunohistochemical changes, and the effect of the growth factors of the platelet-rich plasma on the regeneration and healing of the ulcers. Materials and methods: 38 patients with the trophic ulcers of the lower limbs, caused by diabetes mellitus were involved in the study. To assess the morphological features of the reparative processes before and after the treatment with PRP, the histological and immunohystochemical studies of the biopsy specimen of ulcers were carried out. Results: The total epithelialization of the ulcers in the patients from the main group was achieved on 46.5 day, and in the comparison group – 81.7 day. The light and optical study of the specimen of the main group, using the autologous platelet-rich plasma revealed the elimination of the destructive changes and reduction of the mixed-cellular infiltration compared to the patients from the comparison group. The immunohystochemical study revealed the increase of the growth factors receptors. Conclusions: The usage of the autologous platelet-rich plasma in the treatment of the trophic ulcers results in the rapid regeneration by the decrease of the destructive and inflammatory changes as well as the improvement of the vascularization.

scholarly journals ROLE OF PLATELET RICH PLASMA IN TREATMENT OF CHRONIC NON-HEALING VENOUS ULCER

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Firdaus A. Dekhaiya ◽  
Jignesh K. Joshi ◽  
Sarav Bamania
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Healing Process ◽  
Venous Ulcer ◽  
Lower Limbs ◽  
Venous Ulcers ◽  
Autologous Platelet Rich Plasma ◽  
Adhesive Proteins ◽  
Autologous Platelet

Introduction: Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the lower limbs. Considering that PRP is a source of growth factors, and consequently has mitogenic, angiogenic, and chemotactic properties, it represents an adjunctive treatment for recalcitrant wounds. Moreover, PRP provides the wound with adhesive proteins, such as fibrinogen, which are important in wound healing. PRP contain more amount of platelets, cytokines and growth factors which are dispersed in a very small amount of plasma which can be prepared from a sample of centrifuged autologous blood. Application of PRP has been reported to be effective in both acute as well as chronic non healing venous ulcers. Aim and Objective: To evaluate the efficacy of autologous platelet rich plasma in the management of chronic venous ulcer. Material and Method: A Prospective study conducted on 100 patients of chronic venous ulcers admitted in Sir T. Hospital Bhavnagar from June 2018 to June 2019 after fulfilled our inclusion and exclusion criteria. PRP then injected intalesionally inside and around the periphery of the wound/ulcer. This process was done once/week for 12 weeks. At every week, the area and volume of ulcer was calculated and photographs were taken. Result: All the patients showed healing of the ulcer with reduction in size of ulcer more than 90% was observed in 72 patients, followed by 80–90% reduction in wound size in 18 patients after the 12 weeks follow-up. Overall, significant reduction in size of ulcer was observed in all the treated patients. Conclusion: Autologous platelet rich plasma (PRP) as an autologous method, it is biocompatible, simple, safe, affordable and less expensive procedure in the treatment of chronic venous ulcers. PRP is found to be useful in improving and enhancing the healing process in chronic venous leg ulcers without any side effect. Keywords:  Venous ulcer, Platelet rich plasma

Experimental Morphologic and Clinical Substantiation of Autothrombocytic Growth Factors in Complex Treatment of Achilles Tendon Rupture

2012 ◽  
Vol 19 (4) ◽  
pp. 32-37
Author(s):  
G. A Kesyan ◽  
G. N Berchenko ◽  
T. G Nakhapetyan ◽  
N. S Gavryushenko ◽  
R. Z Uraxgil’deev ◽  
...  
Keyword(s):  
Growth Factors ◽  
Achilles Tendon ◽  
Group Treatment ◽  
Platelet Rich Plasma ◽  
Achilles Tendon Rupture ◽  
Tendon Healing ◽  
Main Group ◽  
Surgical Reconstruction ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Study of the influence of autothrombocytic growth factors upon the injured tendinous tissue was performed. Experimental results (60 Chinchilla rabbits, 3—5 kg) showed that administration of autologous platelet-rich plasma (PRP) into Achilles tendon (AT) injury zone promoted activiza- tion of reparative processes with diminution of inflammatory manifestations; increase in angio- genesis, proliferative and synthetic fibroblasts activity, fibrillogenesis processes; earlier tendon healing. Clinical study included 57 patients (33—68years) with acute (8—48 hours) and old (1—12 months) AT ruptures. After AT surgical reconstruction(Cuneo tendon sutures in acute AC ruptures and Chernavsiautoplasty in the old ones) PRP was additionally administrated to 30 patients from the main group. Treatment results were evaluated by J. Leppilahti and AOFAS scales in 4 months after surgical intervention. In no one patient from the main group AT reruptures were recorded while in control groupreruptures were recorded in 26% of patients.

scholarly journals Treatment of a Refractory Skin Ulcer Using Punch Graft and Autologous Platelet-Rich Plasma

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Mauro Carducci ◽  
Marcella Bozzetti ◽  
Marco Spezia ◽  
Giorgio Ripamonti ◽  
Giuseppe Saglietti
Keyword(s):  
Platelet Rich Plasma ◽  
Skin Grafting ◽  
Lower Limbs ◽  
Alternative Approach ◽  
Speed Up ◽  
Autologous Platelet Rich Plasma ◽  
Dermal Regeneration ◽  
Diabetic Wounds ◽  
Autologous Platelet ◽  
Chronic Ulceration

Background. Chronic ulceration of the lower legs is a relatively common condition amongst adults: one that causes pain and social distress and results in considerable healthcare and personal costs. The technique of punch grafting offers an alternative approach to the treatment of ulcers of the lower limbs.Objective. Combining platelet-rich plasma and skin graft enhances the efficacy of treating chronic diabetic wounds by enhancing healing rate and decreasing recurrence rate. Platelet-rich plasma could, by stimulating dermal regeneration, increase the take rate after skin grafting or speed up reepithelialization.Methods and Materials. The ulcer was prepared by removing fibrin with a curette and the edges of the ulcer were freshened. The platelet-rich plasma has been infiltrated on the bottom and edges of the ulcer. The punch grafts were placed in 5 mm holes arranged. The ulcer was medicated with hydrogel and a pressure dressing was removed after 8 days.Results. After a few days the patient did not report more pain. Granulation tissue appeared quickly between implants. Most of the grafts were viable in 2-3 weeks. The grafts gradually came together to close the ulcer and were completed in four months.

scholarly journals Features of organ-saving foot amputation associated with ozone therapy, local application of autologous platelet-rich plasma and vacuum sanitization of postoperative wound in patients with ischemic-gangrenous form of diabetic foot syndrome

2021 ◽  
Vol 11 (5) ◽  
pp. 237-245
Author(s):  
V. D. Fundiur ◽  
V. K. Grodetskyi ◽  
S. O. Yakobchuk ◽  
O. Y. Khomko ◽  
I. M. Kozlovska ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Platelet Rich Plasma ◽  
Main Group ◽  
Diabetic Foot Syndrome ◽  
Local Application ◽  
Control Group ◽  
Ozone Therapy ◽  
Reparative Process ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Improvement of reparative process of the chronic wounds with the insufficiency of peripheral blood suppling in patients suffering from diabetes mellitus is an important issue requiring further investigation. An optimal choice of surgery, effective renewal of blood supply and active stimulation of tissue repair on the cellular level are essential components of success treatment of this problem.Objective of research: From 2017 to 2020, the efficiency of one of the variants of organ-saving surgery performed on 210 patients with an ischemic-gangrenous form of diabetic foot syndrome was studied.Materials and methods. Control group included 104 patients (49.52%), were the treatment carried out in accordance with the standard scheme. The main group (106 patients - 50.47%) in addition to the standard therapy have used regional ozone therapy, vacuum sanitization and local application of autologous platelet-rich plasma (APRP).Results. These proposed measures reduced the period of clinical treatment to 24±1,2 days in the main group compared to 37±2,4 in the control one. 2 years later, patients of the main group confirmed the formation of a foot stump functionally adapted for walking with angular dislocation of fragments of the cuboid and scaphoid bones.Two years after foot amputation due to the ischemic-gangrenous form of diabetic foot syndrome (DFS), the amount of repeated above knee amputations was 1.8 times higher in the control group in comparison with the main group, which is indicative of a reasonable use of the complex of activate a reparative process in the wound.Conclusions: The suggested modification of the organ-saving and partial foot amputation in patients with IV degree of ischemia and DFS is indicative of a possibility to perform such kind of surgery as a variant of choice.The complex of proposed additional measures including regional ozone therapy, vacuum sanitization and local administration of autologous platelet-rich plasma activates a reparative process of a chronic foot wound and promotes an effective treatment of patients with ischemic-gangrenous form of DFS.

Autologous platelet-rich plasma versus readymade growth factors in skin rejuvenation: A split face study

2017 ◽  
Vol 16 (2) ◽  
pp. 258-264 ◽  
Author(s):  
Heba I Gawdat ◽  
Amira M Tawdy ◽  
Rehab A Hegazy ◽  
Mohga M Zakaria ◽  
Ryham S Allam
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Skin Rejuvenation ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Split Face

scholarly journals Evaluation of graft uptake using temporalis fascia and cartilage perichondrium supplemented with autologous platelet rich plasma in tympanoplasty

2021 ◽  
Vol 7 (2) ◽  
pp. 308
Author(s):  
N. R. Ankle ◽  
Rajesh Radhakrishna Havaldar ◽  
Sweta Sinha
Keyword(s):  
Growth Factors ◽  
Mechanical Stability ◽  
Platelet Rich Plasma ◽  
Donor Site ◽  
Chronic Otitis Media ◽  
Temporalis Fascia ◽  
Autologous Platelet Rich Plasma ◽  
Operative Assessment ◽  
Autologous Platelet ◽  
And Cartilage

<p class="abstract"><strong>Background:</strong> Tympanoplasty involves grafting the perforation of the tympanic membrane with materials such as temporalis fascia, cartilage perichondrium, periosteum, vein, fat etc. Both temporalis fascia and cartilage perichondrium are easy to harvest with minimum donor site complications and both have been used extensively in tympanoplasty. Platelet rich plasma aids as an adhesive and supplements healing by providing growth factors. Till date there is scarcity of literature comparing the healing outcome of both cartilage perichondrium and temporalis fascia supplemented with platelet rich plasma. Hence, in this study we are comparing cartilage perichondrium supplemented with platelet rich plasma and temporalis fascia supplemented with platelet rich plasma.  </p><p class="abstract"><strong>Methods:</strong> An observational study involving 60 patients was done. Patients with chronic otitis media were evaluated by otoendoscopy to assess the ear and were categorised into 2 groups which received temporalis fascia and cartilage perichondrium respectively. All cases were supplemented with platelet rich plasma. Post-operative assessment was done by otoendoscopy.   </p><p class="abstract"><strong>Results:</strong> Total 21 patients received temporalis fascia and 39 patients received cartilage perichondrium. At the end of 6 weeks the graft site appeared unhealthy in 6.66% cases who received temporalis fascia and 1.66% in those who received cartilage perichondrium.  </p><p class="abstract"><strong>Conclusions:</strong> We found that cartilage perichondrium supplemented with platelet rich plasma had a better uptake after 6 weeks due to its superior mechanical stability. The results are more rewarding than the use of temporalis fascia with platelet rich plasma.</p>

Complex treatment of uveitis with macular edema associated with systemic diseases using autologous platelet-rich plasma

2021 ◽  
pp. 148-152
Author(s):  
N.S. Arbenyeva ◽  
◽  
V.I. Bratko ◽  
A.N. Trunov ◽  
V.V. Chernykh ◽  
...  
Keyword(s):  
Macular Edema ◽  
Comparison Group ◽  
Platelet Rich Plasma ◽  
Ophthalmological Examination ◽  
Systemic Diseases ◽  
Complex Treatment ◽  
Autologous Plasma ◽  
Autologous Platelet Rich Plasma ◽  
Anti Inflammatory ◽  
Autologous Platelet

In patients with uveitis associated with systemic diseases, a common cause of low vision is macular edema, which develops at any localization of the inflammatory process in 38–84% of cases. Autologous platelet-rich plasma is widely used in various branches of medicine, however, in the treatment of uveitis accompanied by macular edema, the clinical efficacy of its use has not been sufficiently studied. Purpose. To conduct a clinical and laboratory assessment of the effectiveness of complex treatment of uveitis with macular edema associated with systemic diseases using autologous platelet-rich plasma. Material and methods. The study included 120 people (120 eyes) from 18 to 50 years old with uveitis and macular edema associated with systemic diseases: 51 men, 69 women. Patients were divided into 2 groups: the main group consisted of patients who received anti-inflammatory treatment and administration of autologous plasma platelet-rich; comparison group – patients who received anti-inflammatory treatment. All patients underwent a comprehensive ophthalmological examination. Results. It has been established that the administration of autologous platelet-rich plasma against the background of anti-inflammatory treatment in patients with uveitis associated with systemic diseases accompanied by macular edema improves the maximally corrected visual acuity, a statistically significant decrease in the thickness of the retina in the fovea and an increase in the light sensitivity of the retina, relative to the data obtained in the comparison group. Conclusion. The use of autologous platelet-rich plasma in combination with anti-inflammatory treatment leads to a decrease in the incidence of recurrence of uveitis associated with systemic diseases, helps to reduce macular edema and improve functional parameters. Key words: uveitis, macular edema, anti-inflammatory treatment, autologous platelet-rich plasma.

Use of autologous platelet-rich plasma in trichology

2021 ◽  
pp. 30-32
Author(s):  
A. V. Gismieva
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Promising Treatment ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

The article is of a review nature and contains up-to-date information on the application autologous platelet-rich plasma in trichology. The use of autologous platelet-rich plasma is a promising treatment. The application on this technique is to improve and accelerate the processes caused by the stimulating growth factors contained in platelets.

scholarly journals USE OF AUTOLOGOUS PLATELET-RICH PLASMA WITH THROMBOCYTES IN DERMATOCOSMETOLOGY (REVIEW)

2017 ◽  
Vol 20 (6) ◽  
pp. 368-372
Author(s):  
Ania D. Karagadyan
Keyword(s):  
Growth Factors ◽  
Literature Review ◽  
Platelet Rich Plasma ◽  
Lower Extremities ◽  
Skin Changes ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Plantar Warts

The literature review on use of the autologous platelet-rich plasma (auto-PRP) in dermatocosmetology is presented. The use of PRP is a very perspective method of correction of cosmetology problems associated with involutional skin changes, as well as in the treatment of dermal diseases, such as alopecia, psoriasis, eczema, palmar and plantar warts, photodermatoses, acne, cankers of the lower extremities, vitiligo and rosacea. The strategy of PRP use is to improve and accelerate the processes caused by the stimulating growth factors contained in platelets.

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