scholarly journals ROLE OF PLATELET RICH PLASMA IN TREATMENT OF CHRONIC NON-HEALING VENOUS ULCER

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Firdaus A. Dekhaiya ◽  
Jignesh K. Joshi ◽  
Sarav Bamania
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Healing Process ◽  
Venous Ulcer ◽  
Lower Limbs ◽  
Venous Ulcers ◽  
Autologous Platelet Rich Plasma ◽  
Adhesive Proteins ◽  
Autologous Platelet

Introduction: Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the lower limbs. Considering that PRP is a source of growth factors, and consequently has mitogenic, angiogenic, and chemotactic properties, it represents an adjunctive treatment for recalcitrant wounds. Moreover, PRP provides the wound with adhesive proteins, such as fibrinogen, which are important in wound healing. PRP contain more amount of platelets, cytokines and growth factors which are dispersed in a very small amount of plasma which can be prepared from a sample of centrifuged autologous blood. Application of PRP has been reported to be effective in both acute as well as chronic non healing venous ulcers. Aim and Objective: To evaluate the efficacy of autologous platelet rich plasma in the management of chronic venous ulcer. Material and Method: A Prospective study conducted on 100 patients of chronic venous ulcers admitted in Sir T. Hospital Bhavnagar from June 2018 to June 2019 after fulfilled our inclusion and exclusion criteria. PRP then injected intalesionally inside and around the periphery of the wound/ulcer. This process was done once/week for 12 weeks. At every week, the area and volume of ulcer was calculated and photographs were taken. Result: All the patients showed healing of the ulcer with reduction in size of ulcer more than 90% was observed in 72 patients, followed by 80–90% reduction in wound size in 18 patients after the 12 weeks follow-up. Overall, significant reduction in size of ulcer was observed in all the treated patients. Conclusion: Autologous platelet rich plasma (PRP) as an autologous method, it is biocompatible, simple, safe, affordable and less expensive procedure in the treatment of chronic venous ulcers. PRP is found to be useful in improving and enhancing the healing process in chronic venous leg ulcers without any side effect. Keywords:  Venous ulcer, Platelet rich plasma

scholarly journals REPARATIVE PROCESSES FEATURES IN TROPHIC ULCERS CAUSED BY DIABETES MELLITUS WITH THE USE OF PLATELET-RICH PLASMA

2020 ◽  
Vol 73 (10) ◽  
pp. 2150-2155
Author(s):  
Igor D. Duzhiy ◽  
Andrii S. Nikolaienko ◽  
Vasyl M. Popadynets ◽  
Oleksandr V. Kravets ◽  
Igor Y. Hresko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factors ◽  
Comparison Group ◽  
Platelet Rich Plasma ◽  
Main Group ◽  
Lower Limbs ◽  
Before And After ◽  
Autologous Platelet Rich Plasma ◽  
Inflammatory Changes ◽  
Autologous Platelet

The aim: Was following: the improvement of the treatment results of the lower limbs ulcers, caused by the diabetes mellitus by using our technique of the platelet-rich plasma application; the study of the features of the morphological and immunohistochemical changes, and the effect of the growth factors of the platelet-rich plasma on the regeneration and healing of the ulcers. Materials and methods: 38 patients with the trophic ulcers of the lower limbs, caused by diabetes mellitus were involved in the study. To assess the morphological features of the reparative processes before and after the treatment with PRP, the histological and immunohystochemical studies of the biopsy specimen of ulcers were carried out. Results: The total epithelialization of the ulcers in the patients from the main group was achieved on 46.5 day, and in the comparison group – 81.7 day. The light and optical study of the specimen of the main group, using the autologous platelet-rich plasma revealed the elimination of the destructive changes and reduction of the mixed-cellular infiltration compared to the patients from the comparison group. The immunohystochemical study revealed the increase of the growth factors receptors. Conclusions: The usage of the autologous platelet-rich plasma in the treatment of the trophic ulcers results in the rapid regeneration by the decrease of the destructive and inflammatory changes as well as the improvement of the vascularization.

scholarly journals The Effect of Type 1 Atellocolagen in Association with Blood Self-derivatives in Alveolar Bone Augumentation

2020 ◽  
Vol 71 (4) ◽  
pp. 390-400
Author(s):  
Bogdan-Catalin Alexandru ◽  
Monica Popa ◽  
Cosmin Pestean ◽  
Robert Purdoiu ◽  
Liviu Oana ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Morphogenetic Proteins ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Bovine Bone ◽  
Cartilaginous Tissue ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

The current experimental study was conducted in sheep, which present bone anisotropy and a predisposition to periodontal disease, with alveolar bone resorption, similar to that found in humans. In this study, alveolar bone augmentation was performed using a lyophilized bovine bone xenograft enriched with type 1 atelocollagen, which was combined with autologous platelet-rich plasma (PRP) and advanced platelet-rich fibrin (A-PRF) as a membrane. The results were radiologically and histologically evaluated at six weeks postoperatively. At that time, the transformation of the composite biomaterial was clearly visible, suggesting that the regeneration process started from the periphery of the augmentation mass, which was progressively transformed from a granular eosinophilic material into an undifferentiated hypercellular one, then into fibroblastic, cartilaginous tissue, and finally into new bone and desmodontal-like tissue. This process was most probably induced by all the compounds used, the growth factors found in autologous blood derivatives, including bone morphogenetic proteins (BMPs), as well as type 1 atelocollagen from the graft composition, especially in combination. The composite biomaterial at six weeks postoperatively provided excellent results regarding alveolar bone regeneration, and without any risk, as opposed to that found in overdose of recombinant growth factors.

The “biological chamber” method – use of autologous platelet-rich plasma (PRP) in the treatment of poorly healing lower-leg ulcers of venous origin

2015 ◽  
Vol 87 (6) ◽  
Author(s):  
Dariusz Waniczek ◽  
Wojciech Mikusek ◽  
Tomasz Kamiński ◽  
Mariusz Wesecki ◽  
Zbigniew Lorenc ◽  
...  
Keyword(s):  
Growth Factors ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Lower Leg ◽  
Complete Healing ◽  
Leg Ulcers ◽  
Plasma Therapy ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

AbstractWound healing is a complex pathophysiological process, in which platelets play a crucial role. Platelet alpha-granules release growth factors to the wound bed; the factors are necessary in the healing process. In chronic wounds, such as poorly healing lower-leg ulcers of venous origin, there is decreased activity of multiple growth factors, so the concept of exogenous delivery of such factors seems a logical strategy. Platelet-rich plasma therapy in patients with lower-leg ulcers of venous origin combined with conventional treatment methods (previously ineffective in these patients) seems, based on our observation, an important adjunct leading to recovery.The aim of the study was to present an original method of autologous platelet-rich plasma application through the creation of a sort of “biological chamber” containing a concentrate of growth factors.Material and methods. The described therapy was implemented in 10 patients, who had been ineffectively treated for more than one year in the outpatient setting. Patients with exacerbation of inflammatory process, signs of wound infection and ankle brachial pressure index < 0.8 were excluded from the study. After the application of platelet-rich plasma, further treatment was continued with the use of moist therapy and compression therapy according to a uniform regimen.Results. Complete healing was achieved within 4-10 weeks from the beginning of the product administration in all patients.Conclusion. The presented method seems technically simple, effective and relatively inexpensive

scholarly journals Treatment of a Refractory Skin Ulcer Using Punch Graft and Autologous Platelet-Rich Plasma

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Mauro Carducci ◽  
Marcella Bozzetti ◽  
Marco Spezia ◽  
Giorgio Ripamonti ◽  
Giuseppe Saglietti
Keyword(s):  
Platelet Rich Plasma ◽  
Skin Grafting ◽  
Lower Limbs ◽  
Alternative Approach ◽  
Speed Up ◽  
Autologous Platelet Rich Plasma ◽  
Dermal Regeneration ◽  
Diabetic Wounds ◽  
Autologous Platelet ◽  
Chronic Ulceration

Background. Chronic ulceration of the lower legs is a relatively common condition amongst adults: one that causes pain and social distress and results in considerable healthcare and personal costs. The technique of punch grafting offers an alternative approach to the treatment of ulcers of the lower limbs.Objective. Combining platelet-rich plasma and skin graft enhances the efficacy of treating chronic diabetic wounds by enhancing healing rate and decreasing recurrence rate. Platelet-rich plasma could, by stimulating dermal regeneration, increase the take rate after skin grafting or speed up reepithelialization.Methods and Materials. The ulcer was prepared by removing fibrin with a curette and the edges of the ulcer were freshened. The platelet-rich plasma has been infiltrated on the bottom and edges of the ulcer. The punch grafts were placed in 5 mm holes arranged. The ulcer was medicated with hydrogel and a pressure dressing was removed after 8 days.Results. After a few days the patient did not report more pain. Granulation tissue appeared quickly between implants. Most of the grafts were viable in 2-3 weeks. The grafts gradually came together to close the ulcer and were completed in four months.

Autologous platelet-rich plasma versus readymade growth factors in skin rejuvenation: A split face study

2017 ◽  
Vol 16 (2) ◽  
pp. 258-264 ◽  
Author(s):  
Heba I Gawdat ◽  
Amira M Tawdy ◽  
Rehab A Hegazy ◽  
Mohga M Zakaria ◽  
Ryham S Allam
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Skin Rejuvenation ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Split Face

scholarly journals Evaluation of graft uptake using temporalis fascia and cartilage perichondrium supplemented with autologous platelet rich plasma in tympanoplasty

2021 ◽  
Vol 7 (2) ◽  
pp. 308
Author(s):  
N. R. Ankle ◽  
Rajesh Radhakrishna Havaldar ◽  
Sweta Sinha
Keyword(s):  
Growth Factors ◽  
Mechanical Stability ◽  
Platelet Rich Plasma ◽  
Donor Site ◽  
Chronic Otitis Media ◽  
Temporalis Fascia ◽  
Autologous Platelet Rich Plasma ◽  
Operative Assessment ◽  
Autologous Platelet ◽  
And Cartilage

<p class="abstract"><strong>Background:</strong> Tympanoplasty involves grafting the perforation of the tympanic membrane with materials such as temporalis fascia, cartilage perichondrium, periosteum, vein, fat etc. Both temporalis fascia and cartilage perichondrium are easy to harvest with minimum donor site complications and both have been used extensively in tympanoplasty. Platelet rich plasma aids as an adhesive and supplements healing by providing growth factors. Till date there is scarcity of literature comparing the healing outcome of both cartilage perichondrium and temporalis fascia supplemented with platelet rich plasma. Hence, in this study we are comparing cartilage perichondrium supplemented with platelet rich plasma and temporalis fascia supplemented with platelet rich plasma.  </p><p class="abstract"><strong>Methods:</strong> An observational study involving 60 patients was done. Patients with chronic otitis media were evaluated by otoendoscopy to assess the ear and were categorised into 2 groups which received temporalis fascia and cartilage perichondrium respectively. All cases were supplemented with platelet rich plasma. Post-operative assessment was done by otoendoscopy.   </p><p class="abstract"><strong>Results:</strong> Total 21 patients received temporalis fascia and 39 patients received cartilage perichondrium. At the end of 6 weeks the graft site appeared unhealthy in 6.66% cases who received temporalis fascia and 1.66% in those who received cartilage perichondrium.  </p><p class="abstract"><strong>Conclusions:</strong> We found that cartilage perichondrium supplemented with platelet rich plasma had a better uptake after 6 weeks due to its superior mechanical stability. The results are more rewarding than the use of temporalis fascia with platelet rich plasma.</p>

Use of autologous platelet-rich plasma in trichology

2021 ◽  
pp. 30-32
Author(s):  
A. V. Gismieva
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Promising Treatment ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

The article is of a review nature and contains up-to-date information on the application autologous platelet-rich plasma in trichology. The use of autologous platelet-rich plasma is a promising treatment. The application on this technique is to improve and accelerate the processes caused by the stimulating growth factors contained in platelets.

scholarly journals Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Dominika Wróbel-Dudzińska ◽  
Jorge Alio ◽  
Alejandra Rodriguez ◽  
Ewa Suchodoła-Ratajewicz ◽  
Ewa Kosior-Jarecka ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Subjective Symptoms ◽  
Nerve Paralysis ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Neurotrophic Keratopathy

Purpose. Platelet-rich plasma (PRP) is an autologous blood product without preservatives and rich in proteins and growth factors which make it possible for cells to differentiate, proliferate, and migrate, thus stimulating healing and regeneration of tissues. The aim of this study was to evaluate the efficiency of autologous platelet-rich plasma in the treatment of neurotrophic keratopathy. Methods. The study group consists of 25 patients with nonhealing corneal ulcers due to herpes simplex or herpes zoster infection and facial nerve or trigeminal nerve paralysis as a result of a neurosurgical operation caused by a tumour or stroke. The patients were given autologous platelet-rich plasma drops five times a day and additionally preservative-free artificial tears and a vitamin A ointment at night for maximum 3 months. The following were evaluated: best corrected visual acuity (BCVA), healing of corneal surface, subjective symptoms, and changes in corneal thickness with the use of anterior segment optical coherent tomography (AS-OCT). Results. BCVA before the treatment was 0.10 ± 0.14, and after the treatment it was –0.3 ± 0.27 (p=0.001). Improved visual acuity and less subjective symptoms were observed in all patients. Complete healing of the ulceration was observed in 20 patients (80%). Four patients (16%) experienced considerable improvement of their clinical condition (reduced size and depth of the ulceration and inflammatory state: smaller conjunctival injection and swelling, improved visual acuity, and less subjective symptoms). In one of the patients, an amniotic membrane was transplanted due to the lack of improvement of his local condition. In all patients, the progression of corneal thinning was stopped. An average corneal thickness in its thinnest point was 322.3 ± 125.8 µm before the treatment, and 404.5 ± 118.7 µm (p<0.05) after the treatment. None of the patients reported general or local side effects of the treatment. Conclusions. Autologous platelet-rich plasma is a blood-based product which seems efficient in the treatment of neurotrophic keratopathy.

scholarly journals Efficacy of autologous platelet rich plasma over conventional mechanical fixation methods in split thickness skin grafting

2018 ◽  
Vol 6 (1) ◽  
pp. 108 ◽  
Author(s):  
Girish Umashankar Thimmanahalli ◽  
Mahesh Kumar
Keyword(s):  
Skin Graft ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Split Thickness Skin Graft ◽  
Skin Defect ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting ◽  
Autologous Platelet Rich Plasma ◽  
Graft Reconstruction ◽  
Autologous Platelet

Background: Platelet-Rich Plasma (PRP) is an autologous product derived from whole blood through the process of gradient density centrifugation. After skin graft reconstruction, the healing process is longer and may be difficult, depending on the wound site, skin defect size, and patient comorbidities. The potential value of PRP lies in its ability to incorporate high concentrations of platelet-derived growth factors into the skin graft. Since not all patients afford commercially available recombinant platelet rich plasma for skin graft, platelet extract from patient’s own blood is being used in this study to test and demonstrate the therapeutic role of PRP in skin graft. The aim of this randomized, prospective study is to compare the effectiveness of PRP in skin graft with conventional method like sutures, staplers or glue.Methods: The source of data were the patients admitted as inpatients for the management of wounds to the department of general surgery, JSS Hospital, Mysore from September 2016 to September 2018. Total of 60 patients were studied; 30 cases were randomly chosen for study with autologous platelet rich plasma and 30 cases received conventional methods like staples/sutures used to anchor the skin grafts in a control group.Results: Autologous PRP showed faster and better healing rates. With PRP study group instant graft adherence was seen in all cases. Hematoma, graft edema, discharge from graft site, frequency of dressings and duration of stay in hospital were significantly less in the PRP. There were no adverse effects or reactions seen with the use of autologous PRP among the study group.Conclusions: The combination of PRP with Split Thickness Skin Graft (STSG) significantly improved clinical outcomes and shortened the wound healing time. Therefore, this treatment combination could provide a way to heal skin after skin graft reconstruction with minimal recovery time. It is found to be highly beneficial in many aspects both to the patient and surgeon based on our results.

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