scholarly journals PirB functions as an intrinsic suppressor in hippocampal neural stem cells

Aging ◽  
2021 ◽  
Author(s):  
Baiyang Liu ◽  
Wenjing Cheng ◽  
Dating Cheng ◽  
Jun Pu ◽  
Zhi Nie ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Hippocampal Neural Stem Cells

scholarly journals ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence

2020 ◽  
Author(s):  
Vijay S. Adusumilli ◽  
Tara L. Walker ◽  
Rupert W. Overall ◽  
Gesa M. Klatt ◽  
Salma A. Zeidan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Functional States ◽  
Activity Dependent ◽  
Hippocampal Neural Stem Cells

Altered Nup153 Expression Impairs the Function of Cultured Hippocampal Neural Stem Cells Isolated from a Mouse Model of Alzheimer’s Disease

2019 ◽  
Vol 56 (8) ◽  
pp. 5934-5949 ◽  
Author(s):  
Lucia Leone ◽  
Claudia Colussi ◽  
Katia Gironi ◽  
Valentina Longo ◽  
Salvatore Fusco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Mouse Model ◽  
Neural Stem Cells ◽  
Model Of Alzheimer’S Disease ◽  
Hippocampal Neural Stem Cells

scholarly journals Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain

2019 ◽  
Vol 25 (7) ◽  
pp. 1382-1405 ◽  
Author(s):  
M. Schouten ◽  
P. Bielefeld ◽  
L. Garcia-Corzo ◽  
E. M. J. Passchier ◽  
S. Gradari ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Aging Brain ◽  
Hippocampal Neural Stem Cells

scholarly journals Ghrelin gene products rescue cultured adult rat hippocampal neural stem cells from high glucose insult

2016 ◽  
Vol 57 (3) ◽  
pp. 171-184 ◽  
Author(s):  
Sehee Kim ◽  
Chanyang Kim ◽  
Seungjoon Park
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
High Glucose ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Gene Products ◽  
Growth Hormone Secretagogue ◽  
Phosphohistone H3 ◽  
Ghrelin Gene ◽  
Hippocampal Neural Stem Cells

Adult hippocampal neurogenesis is decreased in type 2 diabetes, and this impairment appears to be important in cognitive dysfunction. Previous studies suggest that ghrelin gene products (acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin (OB)) promote neurogenesis. Therefore, we hypothesize that ghrelin gene products may reduce the harmful effects of high glucose (HG) on hippocampal neural stem cells (NSCs). The aim of this study was to investigate the role of these peptides on the survival of cultured hippocampal NSCs exposed to HG insult. Treatment of hippocampal NSCs with AG, UAG or OB inhibited HG-induced cell death and apoptosis. Exposure of cells to the growth hormone secretagogue receptor 1a antagonist abolished the protective effects of AG against HG toxicity, whereas those of UAG or OB were preserved. All three peptides attenuated HG-induced decrease in BrdU-labeled and phosphohistone-H3-labeled cells. We also investigated the effects of ghrelin gene products on the regulation of apoptosis at the mitochondrial level. AG, UAG or OB rescued hippocampal NSCs from HG insult by inhibiting intracellular and mitochondrial reactive oxygen species generation and stabilizing mitochondrial transmembrane potential. In addition, cells treated with ghrelin gene products showed an increased Bcl-2 and decreased Bax levels, thereby increasing the Bcl-2/Bax ratio, inhibiting cytochrome c release and preventing caspase-3 activation. Finally, AG-, UAG- or OB-mediated protection was dependent on the activities of adenosine monophosphate-activated protein kinase/uncoupling protein 2 pathway. Our data indicate that ghrelin gene products may act as survival factors that preserve mitochondrial function and inhibit oxidative stress-induced apoptosis.

Fty720, Sphingosine 1-phosphate Receptor Modulator, Selectively Radioprotects Hippocampal Neural Stem Cells

2012 ◽  
Vol 84 (3) ◽  
pp. S108
Author(s):  
A. Stessin ◽  
A.G. Wernicke ◽  
B. Parashar ◽  
A.M. Sabbas ◽  
F.G. Kulidzhanov ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Receptor Modulator ◽  
Sphingosine 1 Phosphate ◽  
Hippocampal Neural Stem Cells

P.l.c.041 The role of pro-inflammatory cytokines IL-ip and IL-6 on proliferation of human hippocampal neural stem cells

2009 ◽  
Vol 19 ◽  
pp. S275 ◽  
Author(s):  
P. Zunszain ◽  
C. Anacker ◽  
L. Carvalho ◽  
S. Thuret ◽  
J. Price ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Inflammatory Cytokines ◽  
Hippocampal Neural Stem Cells ◽  
Pro Inflammatory Cytokines

Developmental Exposure of Mice to T-2 Toxin Increases Astrocytes and Hippocampal Neural Stem Cells Expressing Metallothionein

2018 ◽  
Vol 35 (3) ◽  
pp. 668-683 ◽  
Author(s):  
Kota Nakajima ◽  
Takeshi Tanaka ◽  
Yasunori Masubuchi ◽  
Yuko Ito ◽  
Satomi Kikuchi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Developmental Exposure ◽  
Hippocampal Neural Stem Cells

scholarly journals Autophagy Mediates Astrogenesis in Adult Hippocampal Neural Stem Cells

2019 ◽  
Vol 28 (2) ◽  
pp. 229-246 ◽  
Author(s):  
Shinwon Ha ◽  
Seol-Hwa Jeong ◽  
Kyungrim Yi ◽  
Jamie Jeong-Min Chu ◽  
Seolsong Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Hippocampal Neural Stem Cells
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