scholarly journals Prognostic value of androgen receptor in triple negative breast cancer: A meta-analysis

Oncotarget ◽  
2016 ◽  
Vol 7 (29) ◽  
pp. 46482-46491 ◽  
Author(s):  
Changjun Wang ◽  
Bo Pan ◽  
Hanjiang Zhu ◽  
Yidong Zhou ◽  
Feng Mao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative ◽  
Meta Analysis

scholarly journals 189P The prognostic value of androgen receptor in triple negative breast cancer

2020 ◽  
Vol 31 ◽  
pp. S318
Author(s):  
D. Pratiwi ◽  
I. Purwanto ◽  
M.S. Hardianti ◽  
J. Kurnianda ◽  
K. Widayati ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative

scholarly journals Prognostic value of androgen receptor and FOXA1 co-expression in non-metastatic triple negative breast cancer and correlation with other biomarkers

2018 ◽  
Vol 119 (1) ◽  
pp. 76-79 ◽  
Author(s):  
Séverine Guiu ◽  
Caroline Mollevi ◽  
Céline Charon-Barra ◽  
Florence Boissière ◽  
Evelyne Crapez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative

scholarly journals Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 704 ◽  
Author(s):  
Parisa Lotfinejad ◽  
Mohammad Asghari Jafarabadi ◽  
Mahdi Abdoli Shadbad ◽  
Tohid Kazemi ◽  
Fariba Pashazadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Cochrane Library ◽  
P Value ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

This meta-analysis aimed to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1), their associations with the clinicopathological characteristics, and the association between their levels in patients with triple-negative breast cancer (TNBC). PubMed, EMBASE, Scopus, ProQuest, Web of Science, and Cochrane Library databases were searched to obtain the relevant papers. Seven studies with 1152 patients were included in this study. Like the level of TILs, there were no significant associations between PD-L1 expression and tumor size, tumor stage, lymph node metastasis, histological grade, and Ki67 (All p-values ≥ 0.05). Furthermore, there was no significant association between PD-L1 expression with overall survival (OS) and disease-free survival (DFS). In assessment of TILs and survival relationship, the results showed that a high level of TILs was associated with long-term OS (hazard ratios (HR) = 0.48, 95% CI: 0.30 to 0.77, p-value < 0.001) and DFS (HR = 0.53, 95% CI: 0.35 to 0.78, p-value < 0.001). The results displayed that tumoral PD-L1 expression was strongly associated with high levels of TILs in TNBC patients (OR = 8.34, 95% CI: 2.68 to 25.95, p-value < 0.001). In conclusion, the study has shown the prognostic value of TILs and a strong association between tumoral PD-L1 overexpression with TILs in TNBC patients.

scholarly journals Androgen Receptor, EGFR, and BRCA1 as Biomarkers in Triple-Negative Breast Cancer: A Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Li Zhang ◽  
Cheng Fang ◽  
Xianqun Xu ◽  
Anling Li ◽  
Qing Cai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Targeted Therapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Meta Analysis ◽  
Brca1 Mutation ◽  
Expression Level ◽  
Breast Cancer Susceptibility Gene ◽  
Egfr Expression

Objective. More and more evidences demonstrate that androgen receptor (AR), epidermal growth factor receptor (EGFR), and breast cancer susceptibility gene 1 (BRCA1) have unique clinical implications for targeted therapy or prognosis in triple-negative breast cancer (TNBC). Therefore, we conducted a meta-analysis to summarize the possible associations.Methods. We retrieved published articles about AR, EGFR, and BRCA1 in TNBC from PubMed and EMBASE. The analysis was performed with Rev-Man 5.2 software.Results. A total of 38 articles were eligible for the meta-analysis. Our study showed that the expression level of EGFR (OR=6.88,P<0.00001) and the prevalence of BRCA1 mutation (RR=5.26,P<0.00001) were higher in TNBC than non-TNBC. In contrast, the expression level of AR was lower in TNBC than non-TNBC (OR=0.07,P<0.00001). In the subgroup related to EGFR expression, the level of EGFR expression was significantly increased in Asians (OR=9.60) compared with Caucasians (OR=5.53) for TNBC patients. Additionally, the prevalence of BRCA1 mutation in Asians (RR=5.43,P<0.00001) was higher than that in Caucasians (RR=5.16,P<0.00001).Conclusions. The distinct expression of AR and EGFR and the prevalence of BRCA1 mutation indicated that AR, EGFR, and BRCA1 might be unique biomarkers for targeted therapy and prognosis in TNBC.

scholarly journals The significant prognostic value of circulating tumor cells in triple-negative breast cancer: a meta-analysis

Oncotarget ◽  
2016 ◽  
Vol 7 (24) ◽  
pp. 37361-37369 ◽  
Author(s):  
Yan-jun Lu ◽  
Peng Wang ◽  
Xiong Wang ◽  
Jing Peng ◽  
Yao-wu Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative ◽  
Meta Analysis
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