scholarly journals Hepatic NK cell-mediated hypersensitivity to ConA-induced liver injury in mouse liver expressing hepatitis C virus polyprotein

Oncotarget ◽  
2016 ◽  
Vol 8 (32) ◽  
pp. 52178-52192 ◽  
Author(s):  
Qiuxia Fu ◽  
Shaoduo Yan ◽  
Licui Wang ◽  
Xiangguo Duan ◽  
Lei Wang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Injury ◽  
Mouse Liver ◽  
Nk Cell ◽  
Virus Polyprotein

NS3 is a serine protease required for processing of hepatitis C virus polyprotein.

1993 ◽  
Vol 67 (7) ◽  
pp. 4017-4026 ◽  
Author(s):  
L Tomei ◽  
C Failla ◽  
E Santolini ◽  
R De Francesco ◽  
N La Monica
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Serine Protease ◽  
Virus Polyprotein

scholarly journals Branched‐chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein‐expressing mice

2014 ◽  
Vol 35 (4) ◽  
pp. 1303-1314 ◽  
Author(s):  
Masaaki Korenaga ◽  
Sohji Nishina ◽  
Keiko Korenaga ◽  
Yasuyuki Tomiyama ◽  
Naoko Yoshioka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Branched Chain Amino Acids ◽  
Iron Accumulation ◽  
Hepatic Iron ◽  
Branched Chain ◽  
Virus Polyprotein ◽  
And Oxidative Stress

Mechanisms of Liver Injury. III. Oxidative stress in the pathogenesis of hepatitis C virus

2006 ◽  
Vol 290 (5) ◽  
pp. G847-G851 ◽  
Author(s):  
Jinah Choi ◽  
J.-H. James Ou
Keyword(s):  
Oxidative Stress ◽  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Injury ◽  
Iron Overload ◽  
Antioxidant Defense ◽  
Hcv Infection ◽  
Nitrogen Species ◽  
Systemic Oxidative Stress

Hepatitis C virus (HCV) is a major cause of viral hepatitis that can progress to hepatic fibrosis, steatosis, hepatocellular carcinoma, and liver failure. HCV infection is characterized by a systemic oxidative stress that is most likely caused by a combination of chronic inflammation, iron overload, liver damage, and proteins encoded by HCV. The increased generation of reactive oxygen and nitrogen species, together with the decreased antioxidant defense, promotes the development and progression of hepatic and extrahepatic complications of HCV infection. This review discusses the possible mechanisms of HCV-induced oxidative stress and its role in HCV pathogenesis.

Conditional gene expression in hepatitis C virus transgenic mice without induction of severe liver injury using a non-inflammatory Cre-expressing adenovirus

2011 ◽  
Vol 160 (1-2) ◽  
pp. 89-97 ◽  
Author(s):  
Tomoko Chiyo ◽  
Satoshi Sekiguchi ◽  
Masahiro Hayashi ◽  
Yoshimi Tobita ◽  
Yumi Kanegae ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Injury ◽  
Transgenic Mice ◽  
Severe Liver ◽  
Conditional Gene Expression

Acute, Clinically Evident Hepatitis C Virus Infection and Liver Injury

2008 ◽  
Vol 103 ◽  
pp. S152-S153
Author(s):  
Alastair Smith ◽  
Rebecca Burbridge ◽  
Judith Gentile ◽  
Cynthia Guy
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Injury ◽  
Virus Infection ◽  
Hepatitis C Virus Infection
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