scholarly journals Ischemic preconditioning attenuates ischemia/reperfusion injury in rat steatotic liver: role of heme oxygenase-1-mediated autophagy

Oncotarget ◽  
2016 ◽  
Vol 7 (48) ◽  
pp. 78372-78386 ◽  
Author(s):  
Anding Liu ◽  
Enshuang Guo ◽  
Jiankun Yang ◽  
Renlong Li ◽  
Yan Yang ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heme Oxygenase 1 ◽  
Steatotic Liver

scholarly journals Intestinal ischemic preconditioning ameliorates hepatic ischemia/reperfusion injury in rats: Role of heme oxygenase 1 in the second window of protection

2014 ◽  
Vol 21 (1) ◽  
pp. 112-122 ◽  
Author(s):  
Shoichi Kageyama ◽  
Koichiro Hata ◽  
Hirokazu Tanaka ◽  
Hirofumi Hirao ◽  
Toyonari Kubota ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heme Oxygenase 1 ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion ◽  
Second Window Of Protection

scholarly journals Role of heme oxygenase-1/carbon monoxide system in pulmonary ischemia-reperfusion injury☆

2009 ◽  
Vol 9 (2) ◽  
pp. 159-162 ◽  
Author(s):  
Wantie Wang ◽  
Fangyan Wang ◽  
Lu Shi ◽  
Xuguang Jia ◽  
Lina Lin
Keyword(s):  
Carbon Monoxide ◽  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heme Oxygenase 1 ◽  
Pulmonary Ischemia

Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: The role of heme oxygenase-1

2010 ◽  
Vol 10 (6) ◽  
pp. 679-684 ◽  
Author(s):  
Shaohua Song ◽  
Xiaoyun Shen ◽  
Yi Tang ◽  
Zhengxin Wang ◽  
Wenyuan Guo ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heme Oxygenase 1 ◽  
Cold Ischemia

scholarly journals Induction of heme oxygenase‐1 attenuates cerebral ischemia/reperfusion injury: role of heme

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Giovanni Li Volti ◽  
Francesco La Delia ◽  
Agata Zappalà ◽  
Maria Francesca Serapide ◽  
Giovanni Puglisi ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heme Oxygenase 1 ◽  
Cerebral Ischemia Reperfusion ◽  
Cerebral Ischemia Reperfusion Injury

scholarly journals Protective role of heme oxygenase-1 in fatty liver ischemia–reperfusion injury

2018 ◽  
Vol 52 (2) ◽  
pp. 61-72 ◽  
Author(s):  
Shaowei Li ◽  
Masayuki Fujino ◽  
Terumi Takahara ◽  
Xiao-Kang Li
Keyword(s):  
Fatty Liver ◽  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Protective Role ◽  
Heme Oxygenase 1 ◽  
Liver Ischemia

Role of Heme Oxygenase-1 in the Regulation of Blood Pressure and Cardiac Function

2003 ◽  
Vol 228 (5) ◽  
pp. 447-453 ◽  
Author(s):  
Yen-Hsu Chen ◽  
Shaw-Fang Yet ◽  
Mark A. Perrella
Keyword(s):  
Blood Pressure ◽  
Cardiac Function ◽  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heme Oxygenase 1 ◽  
Coronary Artery Ligation ◽  
Regulation Of Blood Pressure

Heme oxygenase (HO) is a cytoprotective enzyme that degrades heme (a potent oxidant) to generate carbon monoxide (a vasodilatory gas that has anti-inflammatory properties), bilirubin (an antioxidant derived from biliverdin), and iron (sequestered by ferritin). Because of the properties of inducible HO (HO-1) and its products, we hypothesized that HO-1 would play an important role in the regulation of cardiovascular function. In this article, we will review the role of HO-1 in the regulation of blood pressure and cardiac function and highlight previous studies from our laboratory using gene deletion and gene overexpression transgenic approaches in mice. These studies will include the investigation of HO-1 in the setting of hypertension (renovascular), hypotension (endotoxemia), and ischemia/reperfusion injury (heart). In a chronic renovascular hypertension model, hypertension, cardiac hypertrophy, acute renal failure, and acute mortality induced by one kidney–one clip surgery were more severe in HO-1-null mice. In addition, HO-1-null mice with endotoxemia had earlier resolution of hypotension, yet the mortality and the incidence of end-organ damage were higher in the absence of HO-1. In contrast, mice with cardiac-specific overexpression of HO-1 had an improvement in cardiac function, smaller myocardial infarctions, and reduced inflammatory and oxidative damage after coronary artery ligation and reperfusion. Taken together, these studies suggest that an absence of HO-1 has detrimental consequences, whereas overexpression of HO-1 plays a protective role in hypoperfusion and ischemia/reperfusion injury.

scholarly journals Remote Ischemic Preconditioning Protects against Liver Ischemia-Reperfusion Injury via Heme Oxygenase-1-Induced Autophagy

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e98834 ◽  
Author(s):  
Yun Wang ◽  
Jian Shen ◽  
Xuanxuan Xiong ◽  
Yonghua Xu ◽  
Hai Zhang ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Remote Ischemic Preconditioning ◽  
Heme Oxygenase 1 ◽  
Liver Ischemia

scholarly journals Deciphering the Role of Heme Oxygenase-1 (HO-1) Expressing Macrophages in Renal Ischemia-Reperfusion Injury

Biomedicines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 306
Author(s):  
Maxime Rossi ◽  
Kéziah Korpak ◽  
Arnaud Doerfler ◽  
Karim Zouaoui Boudjeltia
Keyword(s):  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Interstitial Fibrosis ◽  
Ischemia Reperfusion ◽  
Macrophage Polarization ◽  
Critical Role ◽  
Kidney Injury ◽  
Heme Oxygenase 1

Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). Renal IRI combines major events, including a strong inflammatory immune response leading to extensive cell injuries, necrosis and late interstitial fibrosis. Macrophages act as key players in IRI-induced AKI by polarizing into proinflammatory M1 and anti-inflammatory M2 phenotypes. Compelling evidence exists that the stress-responsive enzyme, heme oxygenase-1 (HO-1), mediates protection against renal IRI and modulates macrophage polarization by enhancing a M2 subset. Hereafter, we review the dual effect of macrophages in the pathogenesis of IRI-induced AKI and discuss the critical role of HO-1 expressing macrophages.

Ischemic Preconditioning Protects Against Liver Ischemia/Reperfusion Injury via Heme Oxygenase-1-Mediated Autophagy

2014 ◽  
Vol 42 (12) ◽  
pp. e762-e771 ◽  
Author(s):  
Anding Liu ◽  
Haoshu Fang ◽  
Weiwei Wei ◽  
Olaf Dirsch ◽  
Uta Dahmen
Keyword(s):  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Heme Oxygenase 1 ◽  
Liver Ischemia
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