Correction: Early assessment of tumor response to photodynamic therapy using combined diffuse optical and diffuse correlation spectroscopy to predict treatment outcome

Management of deep hypothermic (DH) cardiopulmonary bypass (CPB), a critical neuroprotective strategy, currently relies on non-invasive temperature to guide cerebral metabolic suppression during complex cardiac surgery in neonates. Considerable inter-subject variability in temperature response and residual metabolism may contribute to the persisting risk for postoperative neurological injury. To characterize and mitigate this variability, we assess the sufficiency of conventional nasopharyngeal temperature (NPT) guidance, and in the process, validate combined non-invasive frequency-domain diffuse optical spectroscopy (FD-DOS) and diffuse correlation spectroscopy (DCS) for direct measurement of cerebral metabolic rate of oxygen ( CMRO2). During CPB, n = 8 neonatal swine underwent cooling from normothermia to 18℃, sustained DH perfusion for 40 min, and then rewarming to simulate cardiac surgery. Continuous non-invasive and invasive measurements of intracranial temperature (ICT) and CMRO2 were acquired. Significant hysteresis ( p < 0.001) between cooling and rewarming periods in the NPT versus ICT and NPT versus CMRO2 relationships were found. Resolution of this hysteresis in the ICT versus CMRO2 relationship identified a crucial insufficiency of conventional NPT guidance. Non-invasive CMRO2 temperature coefficients with respect to NPT ( Q10 = 2.0) and ICT ( Q10 = 2.5) are consistent with previous reports and provide further validation of FD-DOS/DCS CMRO2 monitoring during DH CPB to optimize management.

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Investigation of diffuse correlation spectroscopy in multi-layered media including the human head

Optics Express ◽

10.1364/oe.16.015514 ◽

2008 ◽

Vol 16 (20) ◽

pp. 15514 ◽

Cited By ~ 64

Author(s):

Louis Gagnon ◽

Michèle Desjardins ◽

Julien Jehanne-Lacasse ◽

Louis Bherer ◽

Frédéric Lesage

Keyword(s):

Layered Media ◽

Human Head ◽

Correlation Spectroscopy ◽

Diffuse Correlation Spectroscopy

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Oxid Comparative Analysis of the Significance of BISAP and MEWS Score for an Early Assessment of Illness Severity and Treatment Outcome of Acute Pancreatitis

Serbian Journal of Experimental and Clinical Research ◽

10.2478/sjecr-2019-0013 ◽

2019 ◽

Vol 0 (0) ◽

Author(s):

Olivera Marinkovic ◽

Slađana Trpkovic ◽

Ana Sekulic ◽

Aleksandra N. Ilic ◽

Nataša Zdravkovc ◽

...

Keyword(s):

Acute Pancreatitis ◽

Intensive Care ◽

Treatment Outcome ◽

Prognostic Value ◽

Fatal Outcome ◽

High Specificity ◽

Early Assessment ◽

Time Points ◽

Additional Costs ◽

Vital Parameters

Abstract The aim of this study was to determine the significance of the use of the BISAP score, which is specific for patients with AP, in relation to the application of the MEWS score that is important for assessing the condition of critically ill patients in intensive care units, but is not specific for patients with AP. The research was conducted as a cohort prospective study and included patients of both sexes, older than 18 and diagnosed with AP. BISAP and MEWS score were monitored at least at four time points: on admission to the hospital (zero), 48 hours, 72 hours and 7 days after admission to the hospital. High levels of discrimination between patients with fatal outcome and cured patients are determined in both cases, with discrimination at MEWS being somewhat higher than BISAP score. The BISAP0 had the best discrimination for BISAP score, AUROC (0.807) and also MEWS0 for MEWS score, AUROC (0.899). In our research, the highest sensitivity was shown by BISAP7d (92.1%) and MEWS48 (88.1%), and a high specificity of 87.5% had BISAP score, 48h, 72h and MEWS score at all four points of measurement. BISAP score has a better prognostic value in relation to the form of pancreatitis, the development of complications and the outcome. However, the calculation of the MEWS score is based on monitoring the basic vital parameters so that its application is much simpler and does not require additional costs.

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Evaluation of Local Skeletal Muscle Blood Flow in Manipulative Therapy by Diffuse Correlation Spectroscopy

Frontiers in Bioengineering and Biotechnology ◽

10.3389/fbioe.2021.800051 ◽

2022 ◽

Vol 9 ◽

Author(s):

Yasuhiro Matsuda ◽

Mikie Nakabayashi ◽

Tatsuya Suzuki ◽

Sinan Zhang ◽

Masashi Ichinose ◽

...

Keyword(s):

Blood Pressure ◽

Skeletal Muscle ◽

Blood Flow ◽

Muscle Blood Flow ◽

Nervous Activity ◽

Correlation Spectroscopy ◽

Autonomic Nervous Activity ◽

Local Blood Flow ◽

Diffuse Correlation Spectroscopy ◽

Manipulative Therapy

Manipulative therapy (MT) is applied to motor organs through a therapist’s hands. Although MT has been utilized in various medical treatments based on its potential role for increasing the blood flow to the local muscle, a quantitative validation of local muscle blood flow in MT remains challenging due to the lack of appropriate bedside evaluation techniques. Therefore, we investigated changes in the local blood flow to the muscle undergoing MT by employing diffuse correlation spectroscopy, a portable and emerging optical measurement technology that non-invasively measures blood flow in deep tissues. This study investigated the changes in blood flow, heart rate, blood pressure, and autonomic nervous activity in the trapezius muscle through MT application in 30 volunteers without neck and shoulder injury. Five minutes of MT significantly increased the median local blood flow relative to that of the pre-MT period (p < 0.05). The post-MT local blood flow increase was significantly higher in the MT condition than in the control condition, where participants remained still without receiving MT for the same time (p < 0.05). However, MT did not affect the heart rate, blood pressure, or cardiac autonomic nervous activity. The post-MT increase in muscle blood flow was significantly higher in the participants with muscle stiffness in the neck and shoulder regions than in those without (p < 0.05). These results suggest that MT could increase the local blood flow to the target skeletal muscle, with minimal effects on systemic circulatory function.

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