scholarly journals Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2α/androgen receptor signals

Oncotarget ◽  
2015 ◽  
Vol 6 (29) ◽  
pp. 27555-27565 ◽  
Author(s):  
Jie Luo ◽  
Soo Ok Lee ◽  
Yun Cui ◽  
Rachel Yang ◽  
Lei Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Androgen Receptor ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Prostate Cancer Cell ◽  
Cancer Cell Invasion ◽  
Marrow Mesenchymal Stem Cells

scholarly journals ETV1 Is a Novel Androgen Receptor-Regulated Gene that Mediates Prostate Cancer Cell Invasion

2007 ◽  
Vol 21 (8) ◽  
pp. 1835-1846 ◽  
Author(s):  
Changmeng Cai ◽  
Chen-Lin Hsieh ◽  
Josephat Omwancha ◽  
Zhe Zheng ◽  
Shao-Yong Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Prostate Cancer Cell ◽  
Cancer Cell Invasion

Androgen receptor suppresses prostate cancer cell invasion via altering the miR-4496/β-catenin signals

2018 ◽  
Vol 504 (1) ◽  
pp. 82-88 ◽  
Author(s):  
Rui-feng Wang ◽  
Zhi-feng Wang ◽  
Qing Cheng ◽  
Guo-ren Wang ◽  
Zhi-ming Bai
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Prostate Cancer Cell ◽  
Cancer Cell Invasion

scholarly journals Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase

Oncotarget ◽  
2015 ◽  
Vol 6 (9) ◽  
pp. 6862-6876 ◽  
Author(s):  
Jelani C. Zarif ◽  
Laura E. Lamb ◽  
Veronique V. Schulz ◽  
Eric A. Nollet ◽  
Cindy K. Miranti
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Prostate Cancer Cell ◽  
Cancer Cell Invasion

Bone Marrow Mesenchymal Stem Cells (BMSCs) Restrain the Malignant Behaviors of A549 Lung Cancer Cells Under Hypoxia via miR-145

2022 ◽  
Vol 12 (3) ◽  
pp. 597-601
Author(s):  
Haibin Song ◽  
Heng Zhang ◽  
Lei Li
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Invasion ◽  
A549 Cells ◽  
Hypoxia Group ◽  
Marrow Mesenchymal Stem Cells ◽  
Lung Cancer Stem Cells

Deriving from bone marrow, the bone marrow mesenchymal stem cells (BMSCs) possess multipolar chemotaxis, proliferation potential, along with the capability to differentiate into various types of cells. Moreover, the hypoxic stimulation can effectively induce BMSCs differentiation. This study intends to explore the impediment of BMSCs on malignant behaviors of lung cancer stem cells under hypoxia. A co-culture system of BMSCs with A549 cells was established and then assigned into normoxia group, hypoxia group (50, 100, and 200 nmol/L) followed by analysis of cell viability by CCK-8 assay and miR-145 expression by qRT-PCR. In addition, A549 cells were grouped into NC group, miR-145-mimics group, and miR-145-inhibitors group followed by analysis of cell invasion and levels of miR-145 and Oct4. Hypoxia group exhibited a reduced cell viability and higher miR-145 expression (146.01±21.23%) compared to normoxia group (P < 0.05). Transfection of miR-145-mimic significantly upregulated miR-145 and decreased cell invasion (7.49±1.43%) compared with miR-145-inhibitors group or NC group (P < 0.05). Meanwhile, Oct4 level in miR-145-mimics group (0.934±2.98) was significantly decreased (P < 0.05). In conclusion, under hypoxia condition, the co-culture with BMSCs can upregulated miR-145 level, effectively reduce the viability of lung cancer stem cells and restrain proliferation capability.

scholarly journals Androgens regulate SMAD ubiquitination regulatory factor-1 expression and prostate cancer cell invasion

The Prostate ◽  
2015 ◽  
Vol 75 (6) ◽  
pp. 561-572 ◽  
Author(s):  
Xiaokun Gang ◽  
Guixia Wang ◽  
Haojie Huang
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Prostate Cancer Cell ◽  
Cancer Cell Invasion ◽  
Regulatory Factor

scholarly journals Finasteride Inhibits Human Prostate Cancer Cell Invasion through MMP2 and MMP9 Downregulation

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e84757 ◽  
Author(s):  
Andrei Moroz ◽  
Flávia K. Delella ◽  
Rodrigo Almeida ◽  
Lívia Maria Lacorte ◽  
Wágner José Fávaro ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Prostate Cancer Cell ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Cancer Cell Invasion ◽  
Human Prostate Cancer Cell
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