scholarly journals Adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of recurrent high-grade glioma

Oncotarget ◽  
2015 ◽  
Vol 7 (4) ◽  
pp. 4369-4378 ◽  
Author(s):  
Nan Ji ◽  
Danhui Weng ◽  
Cang Liu ◽  
Zheng Gu ◽  
Shizhang Chen ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
High Grade Glioma ◽  
High Grade ◽  
Simplex Virus

scholarly journals Efficacy of HER2 retargeted herpes simplex virus as therapy for high-grade glioma in immunocompetent mice

2012 ◽  
Vol 19 (11) ◽  
pp. 788-795 ◽  
Author(s):  
E Reisoli ◽  
E Gambini ◽  
I Appolloni ◽  
V Gatta ◽  
M Barilari ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
High Grade Glioma ◽  
High Grade ◽  
Immunocompetent Mice ◽  
Simplex Virus

scholarly journals HG-08ONCOLYTIC HERPES SIMPLEX VIRUS: AN ANTI-INVASIVE THERAPEUTIC STRATEGY FOR PAEDIATRIC HIGH GRADE GLIOMA AND DIFFUSE INTRINSIC PONTINE GLIOMA

2016 ◽  
Vol 18 (suppl 3) ◽  
pp. iii49.3-iii49
Author(s):  
Julia Cockle ◽  
Elizabeth Ilett ◽  
Anke Brüning-Richardson ◽  
Jill Thompson ◽  
Tim Kottke ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Therapeutic Strategy ◽  
High Grade Glioma ◽  
Diffuse Intrinsic Pontine Glioma ◽  
High Grade ◽  
Pontine Glioma ◽  
Simplex Virus

scholarly journals Replication-competent Herpes Simplex Virus Retargeted to HER2 as Therapy for High-grade Glioma

2012 ◽  
Vol 20 (5) ◽  
pp. 994-1001 ◽  
Author(s):  
Eleonora Gambini ◽  
Elisa Reisoli ◽  
Irene Appolloni ◽  
Valentina Gatta ◽  
Gabriella Campadelli-Fiume ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
High Grade Glioma ◽  
High Grade ◽  
Simplex Virus

scholarly journals 925. Novel Fusion Enzymes of Herpes Simplex Virus Thymidine Kinase Mutants and Guanylate Kinase for Improved Cancer Cell Ablation

2006 ◽  
Vol 13 ◽  
pp. S357
Author(s):  
Andressa Ardiani ◽  
Candice Willmon ◽  
Elizabeth Krabbenhoft ◽  
Margaret E. Black
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Cancer Cell ◽  
Guanylate Kinase ◽  
Cell Ablation ◽  
Fusion Enzymes ◽  
Simplex Virus

scholarly journals Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1

1979 ◽  
Vol 7 (4) ◽  
pp. 859-878 ◽  
Author(s):  
N.M. Wilkie ◽  
J.B. Clements ◽  
W. Boll ◽  
N. Mantei ◽  
D. Lonsdale ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Thymidine Kinase Gene ◽  
Herpes Simplex Virus 1 ◽  
Kinase Gene ◽  
Simplex Virus

scholarly journals Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene.

1982 ◽  
Vol 2 (4) ◽  
pp. 426-436 ◽  
Author(s):  
C J Tabin ◽  
J W Hoffmann ◽  
S P Goff ◽  
R A Weinberg
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Dna Sequences ◽  
Leukemia Virus ◽  
Chimeric Virus ◽  
Animal Cells ◽  
Kinase Gene ◽  
General Applicability ◽  
Simplex Virus

We investigated the feasibility of using retroviruses as vectors for transferring DNA sequences into animal cells. The thymidine kinase (tk) gene of herpes simplex virus was chosen as a convenient model. The internal BamHI fragments of a DNA clone of Moloney leukemia virus (MLV) were replaced with a purified BamHI DNA segment containing the tk gene. Chimeric genomes were created carrying the tk insert in both orientations relative to the MLV sequence. Each was transfected into TK- cells along with MLV helper virus, and TK+ colonies were obtained by selection in the presence of hypoxanthine, aminopterin, and thymidine (HAT). Virus collected from TK+-transformed, MLV producer cells passed the TK+ phenotype to TK- cells. Nonproducer cells were isolated, and TK+ transducing virus was subsequently rescued from them. The chimeric virus showed single-hit kinetics in infections. Virion and cellular RNA and cellular DNA from infected cells were all shown to contain sequences which hybridized to both MLV- and tk-specific probes. The sizes of these sequences were consistent with those predicted for the chimeric virus. In all respects studied, the chimeric MLV-tk virus behaved like known replication-defective retroviruses. These experiments suggest great general applicability of retroviruses as eucaryotic vectors.

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