Symmetric Control Systems

Author(s):  
A.I. Diveev ◽  
E.A. Sofronova

The paper focuses on the properties of symmetric control systems, whose distinctive feature is that the solution of the optimal control problem for an object, the mathematical model of which belongs to the class of symmetric control systems, leads to the solution of two problems. The first optimal control problem is the initial one; the result of its solution is a function that ensures the optimal movement of the object from the initial state to the terminal one. In the second problem, the terminal state is the initial state, and the initial state is the terminal state. The complexity of the problem being solved is due to the increase in dimension when the models of all objects of the group are included in the mathematical model of the object, as well as the emerging dynamic phase constraints. The presence of phase constraints in some cases leads to the target functional having several local extrema. A theorem is proved that under certain conditions the functional is not unimodal when controlling a group of objects belonging to the class of symmetric systems. A numerical example of solving the optimal control problem with phase constraints by the Adam gradient method and the evolutionary particle swarm method is given. In the example, a group of two symmetrical objects is used as a control object

2021 ◽  
Vol 18 (1) ◽  
pp. 1-10
Author(s):  
N Izzati ◽  
A Andriani

Indonesia is one of the countries where has not been free from diphtheria outbreak. During 2017-2019, there were 2870 diphtheria cases with 96 deaths. With the mortality rate 5-20%, makes studies regarding diphtheria prevention and management strategies become important to do. In this study, a SEIQR mathematical model was constructed by considering the factor of natural immunity rate in exposed individuals. Then, by considering the complete basic immunization coverage and the proportion of the number of individuals with natural immunity rate as control variables, the optimal control problem is formulated to minimize the number of infected poopulation. Optimal control using DOTcvpSB toolbox obtained that the number of exposed population in the model decreased from 4.9% to 0.75%, and the number of infected population decreased from 3.1% to 0.32%.


2020 ◽  
Vol 15 ◽  
pp. 69
Author(s):  
Maciej Leszczyński ◽  
Urszula Ledzewicz ◽  
Heinz Schättler

An optimal control problem for an abstract mathematical model for cancer chemotherapy is considered. The dynamics is for a single drug and includes pharmacodynamic (PD) and pharmacokinetic (PK) models. The aim is to point out qualitative changes in the structures of optimal controls that occur as these pharmacometric models are varied. This concerns (i) changes in the PD-model for the effectiveness of the drug (e.g., between a linear log-kill term and a non-linear Michaelis-Menten type Emax-model) and (ii) the question how the incorporation of a mathematical model for the pharmacokinetics of the drug effects optimal controls. The general results will be illustrated and discussed in the framework of a mathematical model for anti-angiogenic therapy.


2010 ◽  
Vol 72 (3-4) ◽  
pp. 1235-1246 ◽  
Author(s):  
Darya Filatova ◽  
Marek Grzywaczewski ◽  
Nikolay Osmolovskii

1966 ◽  
Vol 88 (2) ◽  
pp. 306-310 ◽  
Author(s):  
Masanao Aoki

The paper discusses optimal controls of processes with unknown constant parameters, where the processes are such that no measurements on the parameters are available during control periods. The general formulation of this optimal control problem is given for such systems, and it is shown that the formulation becomes quite simple when the equation for the observed-state vector is invertible, and that the problems of estimation and optimal controls cannot be separated for the class of problems discussed in the paper even when the systems are linear with quadratic criterion functions.


Mathematics ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 21
Author(s):  
Askhat Diveev ◽  
Elizaveta Shmalko ◽  
Vladimir Serebrenny ◽  
Peter Zentay

This paper presents a new formulation of the optimal control problem with uncertainty, in which an additive bounded function is considered as uncertainty. The purpose of the control is to ensure the achievement of terminal conditions with the optimal value of the quality functional, while the uncertainty has a limited impact on the change in the value of the functional. The article introduces the concept of feasibility of the mathematical model of the object, which is associated with the contraction property of mappings if we consider the model of the object as a one-parameter mapping. It is shown that this property is sufficient for the development of stable practical systems. To find a solution to the stated problem, which would ensure the feasibility of the system, the synthesized optimal control method is proposed. This article formulates the theoretical foundations of the synthesized optimal control. The method consists in making the control object stable relative to some point in the state space and to control the object by changing the position of the equilibrium points. The article provides evidence that this approach is insensitive to the uncertainties of the mathematical model of the object. An example of the application of the method for optimal control of a group of robots is given. A comparison of the synthesized optimal control method with the direct method on the model without disturbances and with them is presented.


Author(s):  
Jana L. Gevertz ◽  
James M. Greene ◽  
Eduardo D. Sontag

AbstractThis paper continues the study of a model which was introduced in earlier work by the authors to study spontaneous and induced evolution to drug resistance under chemotherapy. The model is fit to existing experimental data, and is then validated on additional data that had not been used when fitting. In addition, an optimal control problem is studied numerically.


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