scholarly journals Effect of antihypertensive therapy on cognitive function in hypertensive patients with obesity

2012 ◽  
Vol 18 (4) ◽  
pp. 325-333 ◽  
Author(s):  
I. B. Zueva ◽  
K. I. Vanaeva ◽  
E. L. Sanez ◽  
N. V. Moroshkina
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Cognitive Function ◽  
Arterial Hypertension ◽  
Evoked Potential ◽  
Blood Pressure Monitoring ◽  
Neuropsychological Testing ◽  
Pressure Monitoring ◽  
Hypertensive Patients ◽  
Design And Methods

Objective. To assess and compare efficacy of perindopril, eprosartan and amlodipine according to their effects on cognitive function in patients with arterial hypertension and obesity. Design and methods. This open clinical trial included 78 patients (mean age — 46,8 ± 5,5 years), 26 of them received perindopril, 26 — eprosartan, and 26 — amlodipine. Monotherapy has lasted for 12 months. At baseline and 12 months later, all participants underwent 24-hour blood pressure monitoring, neuropsychological testing and cognitive evoked potential (P300) to assess cognitive function. Results. Twelve-month monotherapy with eprosartan and amlodipine significantly improved cognitive function (neuropsychological testing and P300) in patients with obesity and arterial hypertension.

scholarly journals The impact of simvastatin vs. atorvastatin on cognitive function in obese hypertensives

2012 ◽  
Vol 18 (3) ◽  
pp. 228-234
Author(s):  
I. B. Zueva ◽  
K. I. Vanaeva ◽  
E. L. Sanez
Keyword(s):  
Clinical Trial ◽  
Cognitive Function ◽  
Evoked Potential ◽  
Neuropsychological Testing ◽  
Hypertensive Patients ◽  
Atorvastatin Therapy ◽  
Design And Methods ◽  
The Impact

Objective. To assess the influence of simvastatin vs. atorvastatin therapy on cognitive function in obese hypertensive patients. Design and methods. This open clinical trial included 40 patients (mean age 47,7 ± 5,6 years). 20 patients received simvastatin and 20 — atorvastatin. Monotherapy lasted 12 months. At baseline and 12 months later, all participants underwent neuropsychological testing and cognitive evoked potential (P300) to assess cognitive function. Results. 12-month therapy with simvastatin and atorvastatin significantly improved cognitive function (neuropsychological testing and P300) in obese hypertensives.

scholarly journals Genetic markers of antihypertensive drug efficacy

2010 ◽  
Vol 16 (4) ◽  
pp. 407-411 ◽  
Author(s):  
N. R. Khasanov
Keyword(s):  
Blood Pressure ◽  
Genetic Markers ◽  
Blood Pressure Monitoring ◽  
Renin Angiotensin System ◽  
Drug Efficacy ◽  
Antihypertensive Efficacy ◽  
Pressure Monitoring ◽  
Angiotensin System ◽  
Hypertensive Patients ◽  
Design And Methods

Objective. To assess the antihypertensive efficacy of monotherapy with Nifedipine Retard, Enalapril and Metoprolol in view of polymorphism of genes associated with lipid metabolism, renin-angiotensin system, β-adrenoreceptor and apoptosis cascade in patients with essential hypertension. Design and methods. 150 Tatar hypertensive patients were included, and blood pressure monitoring and gene polymorphism determination were performed. Antihypertensive therapy was prescribed for one month. Results. There are associations between antihypertensive efficacy and the number of genetic markers in hypertensive patients. We suppose that protein products encoded by GluR2, HIF-1А, CASP9, Ephrin-B3 genes play a role either in blood pressure regulation or in the mechanism of blood pressure decrease under therapy with Nifedipine Retard, Enalapril or Metoprolol. Conclusion. GluR2, HIF-1А, CASP9, Ephrin-B3 genes polymorphisms can be used to predict the efficacy of treatment with Nifedipine Retard, Enalapril and Metoprolol in hypertensive patients.

Ambulatory blood pressure monitoring-based definition of true arterial hypertension

2020 ◽  
Vol 111 (6) ◽  
Author(s):  
Ramón C. Hermida ◽  
Artemio Mojón ◽  
José R. Fernández ◽  
Alfonso Otero ◽  
Juan J. Crespo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Ambulatory Blood Pressure Monitoring ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Pressure Monitoring ◽  
Definition Of

scholarly journals The Key Role of Ambulatory Blood Pressure Monitoring in the Detection of Masked Hypertension and Other Phenomena in Frail Geriatric Patients

Medicina ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 1221
Author(s):  
Marek Koudelka ◽  
Eliška Sovová
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Ambulatory Blood Pressure Monitoring ◽  
Ambulatory Blood Pressure ◽  
Geriatric Patients ◽  
Blood Pressure Monitoring ◽  
Target Range ◽  
Masked Hypertension ◽  
Pressure Monitoring

Background and Objectives: This study aims to determine prevalence of masked uncontrolled hypertension (MUH) in frail geriatric patients with arterial hypertension and thus show the role of ambulatory blood pressure monitoring (ABPM) since hypertension occurs in more than 80% of people 60+ years and cardiovascular diseases are the main cause of death worldwide. Despite modern pharmacotherapy, use of combination therapy and normal office blood pressure (BP), patients’ prognoses might worsen due to inadequate therapy (never-detected MUH). Materials and Methods: 118 frail geriatric patients (84.2 ± 4.4 years) treated for arterial hypertension with office BP < 140/90 mmHg participated in the study. 24-h ABPM and clinical examination were performed. Results: Although patients were normotensive in the office, 24-h measurements showed that BP values in 72% of hypertensives were not in the target range: MUH was identified in 47 (40%) patients during 24 h, in 48 (41%) patients during daytime and nocturnal hypertension in 60 (51%) patients. Conclusions: ABPM is essential for frail geriatric patients due to high prevalence of MUH, which cannot be detected based on office BP measurements. ABPM also helps to detect exaggerated morning surge, isolated systolic hypertension, dipping/non-dipping, and set and properly manage adequate treatment, which reduces incidence of cardiovascular events and contributes to decreasing the financial burden of society.

scholarly journals Perbedaan Derajat Ansietas antara Penyandang Hipertensi Belum Terkontrol dengan yang Terkontrol

e-CliniC ◽  
2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Cerelia E. C. Sugeng ◽  
Emma Sy. Moeis ◽  
Glady I. Rambert
Keyword(s):  
Blood Pressure ◽  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Blood Pressure Monitoring ◽  
Office Blood Pressure ◽  
Generalized Anxiety ◽  
Pressure Monitoring ◽  
Hypertensive Patients ◽  
Significant Difference ◽  
The Difference

Abstract: Hypertension and anxiety are among the group of the most common chronic disease worldwide, and according to numerous studies they are oftentimes associated each other. Patients suffered from chronic illnesses, such as hypertension, may have negative emotion that increases the risk of mental disorders, most commonly anxiety disorder. This study was aimed to assess the difference of anxiety degree between uncontrolled and controlled hypertensive patients. This was an observational analytical study with a cross-sectional design. Subjects were divided into two groups: controlled and uncontrolled hypertensive patients. Measurement of blood pressure parameter was performed by using office blood pressure monitoring. Anxiety parameter was classified based on the scoring of the Generalized Anxiety Disorder Scale (GAD-7). Data were analyzed by using the Mann-Whitney test. Subjects consisted of 60 hypertensive patients (35 males and 25 females), aged 30-70 years (mean 56.48 years). There were 35 controlled hypertension patients and 22 uncontrolled hypertensive patients. The results showed that the difference in anxiety degree based on GAD-7 between controlled hypertensive and uncontrolled hypertensive groups obtained a p-value of 0.000. In conclusion, there was a significant difference in anxiety degree between uncontrolled and controlled hypertensive patients. Screening for anxiety among hypertensive patients is a simple and cost-effective tool that may improve outcomes.Keywords: anxiety, uncontrolled hypertension, controlled hypertension Abstrak: Hipertensi dan ansietas merupakan kelompok penyakit kronik yang paling umum di seluruh dunia. Berdasarkan banyak penelitian kedua penyakit ini saling berhubungan satu sama lain. Penyandang hipertensi mungkin memiliki emosi negatif yang meningkatkan risiko terjadinya gangguan mental berupa ansietas. Ansietas dan dukungan sosial rendah akan menghambat proses penyembuhan terutama dalam mengontrol tekanan darah. Penelitian ini bertujuan untuk menge-tahui apakah terdapat perbedaan derajat ansietas antara penyandang hipertensi belum terkontrol dengan hipertensi terkontrol. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Subyek penelitian dibagi menjadi dua kelompok, yaitu kelompok penyandang hipertensi belum terkontrol dan hipertensi terkontrol. Pengukuran parameter tekanan darah dilakukan dengan menggunakan alat Oscillometric digital dengan cara Office Blood Pressure Monitoring (OBPM). Parameter ansietas diklasifikasikan berdasarkan skala Generalized Anxiety Disorder Scale (GAD-7). Adanya perbedaan derajat ansietas antara kedua kelompok dinilai dengan uji Mann-Whitney. Subyek penelitian terdiri dari 60 penyandang hipertensi (35 laki-laki dan 25 perempuan) berusia 30-70 tahun (rerata 56,48 tahun). Terdapat 25 penyandang hipertensi yang belum terkontrol dan 35 penyandang hipertensi terkontrol. Hasil penelitian menunjukkan bahwa terdapat perbedaan derajat ansietas berdasarkan GAD-7 antara kedua kelompok (p=0,000). Simpulan penelitian ini ialah terdapat perbedaan bermakna dalam derajat ansietas antara penyandang hipertensi yang belum terkontrol dengan yang terkontrol. Skrining ansietas pada penyandang hipertensi merupakan modalitas penting dalam penatalaksanaan penyandang hipertensi.Kata kunci: ansietas, hipertensi belum terkontrol, hipertensi terkontrol

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