Urinary Tract Infection (Acute Cystitis), Canadian Guideline

Author(s):  
Cheryl A. Glass ◽  
Debbie Gunter ◽  
Kristie A. D. Morydz
2019 ◽  
pp. 87-92
Author(s):  
A. A. Balushkina ◽  
N. E. Kan ◽  
V. L. Tyutyunnik

The urinary tract infection continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy reproductive women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial urinary tract infection. Rising antimicrobial resistance among uropathogenic bacteria further complicates therapeutic decisions, necessitating new approaches based on fundamental investigation.


Author(s):  
Андрей Владимирович Кузьменко ◽  
Владимир Васильевич Кузьменко ◽  
Тимур Асланбекович Гяургиев ◽  
Мария Николаевна Химичева ◽  
Наталья Ивановна Кузьмина

Острый цистит является самым частым проявлением неосложненной инфекции мочевых путей. Одним из препаратов, чья эффективность в лечении больных с ИНМП доказана, является фосфомицин, который в течение длительного времени широко применяется в урологической практике. Несмотря на хорошие результаты этиотропной терапии, неразрешенной остается проблема рецидивирования ИМП. У каждой 3 женщины к 24 годам в анамнезе имеется эпизод острого цистита которая возникает примерно у 30% женщин в течении года после первого эпизода цистита. Частое рецидивирование данного заболевания влечет за собой существенные последствия, затрагивающие все сферы жизни женщины, практически парализуя ежедневный распорядок дня. Ярко выраженные симптомы, такие как постоянные позывы к мочеиспусканию, рези при мочеиспускании лишают трудоспособности, полноценного ночного сна и половой жизни. Ограничивают возможность свободного передвижения, что необходимо учитывать, особенно в постоянно растущем ритме жизни. Это создает необходимость в поиске средств, продляющих безрицидивный период, тем самым снижая отрицательное влияние данного заболевания на жизнь пациенток Альтернативные профилактические средства, находят все более широкое применение. Одним из таких средств является D-манноза. В данном исследовании была проведена оценка эффективности терапии фосфомицином с обогащением рациона питания источником D - маннозы и фосфомицина - в комплексном лечении женщин с неосложненной инфекцией нижних мочевых путей Acute cystitis is the most common manifestation of uncomplicated urinary tract infection. One of the drugs whose effectiveness in the treatment of patients with INMP has been proven is fosfomycin, which has been widely used in urological practice for a long time. Despite the good results of etiotropic therapy, the problem of recurrent UTI remains unresolved. Every 3 women have a history of acute cystitis by the age of 24, which occurs in approximately 30% of women within a year after the first episode of cystitis. Frequent recurrence of this disease entails significant consequences that affect all areas of a woman's life, practically paralyzing the daily routine. Pronounced symptoms, such as constant urge to urinate, pain when urinating, deprive the ability to work, a full night's sleep and sexual activity. They restrict the possibility of free movement, which must be taken into account, especially in the ever-growing pace of life. This creates the need to search for means that extend the disease-free period, thereby reducing the negative impact of this disease on the lives of patients. Alternative preventive means are becoming more widely used. One such remedy is D-mannose. In this study, we evaluated the effectiveness of fosfomycin therapy with a source of D - mannose and fosfomycin in the complex treatment of women with uncomplicated lower urinary tract infection


Author(s):  
E. M. Pleshkova ◽  
V. V. Dlin

Research purpose. To determine the frequency and severity of connective tissue dysplasia in children with urinary tract infection to predict the course of the disease and justify the scope of the survey.Characteristics of children and research methods. A prospective study was conducted during 5 years, which included 120 children with community-acquired urinary tract infection at the age of 1 to 17 years. There were 90 children with acute pyelonephritis and 30 patients with acute cystitis. All children underwent a clinical and instrumental examination with a study of the manifestations of connective tissue dysplasia and assessment of its severity.Results. Connective tissue dysplasia occurred in 30% of children with urinary tract infection and depended on the form and course of pyelonephritis. With secondary pyelonephritis, its frequency increased to 56% with a predominance of the first degree of severity. When prospectively observed, only in 2 out of 30 girls with acute cystitis, the disease took a chronic course; one of them was diagnosed with connective tissue dysplasia of the I degree of severity. A relapse-free course of pyelonephritis was observed in 54 (68%) children. In 25 (32%) patients with secondary pyelonephritis, the course of the disease was recurring; in this group, connective tissue dysplasia was significantly more frequent and was observed in 23 (92%) of 25 patients.Conclusion. If seven to ten external signs of connective tissue dysplasia are detected in children with pyelonephritis, it is necessary to examine not only the urinary system, but also other systems for complex treatment.


Biology Open ◽  
2021 ◽  
Vol 10 (8) ◽  
Author(s):  
Nicole M. Gilbert ◽  
Brian Choi ◽  
Jingjie Du ◽  
Christina Collins ◽  
Amanda L. Lewis ◽  
...  

ABSTRACT In recent years, the clinical significance of Aerococcus urinae has been increasingly recognized. A. urinae has been implicated in cases of urinary tract infection (UTI; acute cystitis and pyelonephritis) in both male and female patients, ranging from children to older adults. Aerococcus urinae can also be invasive, causing urosepsis, endocarditis, and musculoskeletal infections. Mechanisms of pathogenesis in A. urinae infections are poorly understood, largely due to the lack of an animal model system. In response to this gap, we developed a model of A. urinae urinary tract infection in mice. We compared A. urinae UTI in female C3H/HeN and C57BL/6 mice and compared four clinical isolates of A. urinae isolated from patients with UTI, urgency urinary incontinence, and overactive bladder. Our data demonstrate that host genetic background modulates A. urinae UTI. Female C57BL/6 female mice rapidly cleared the infection. Female C3H/HeN mice, which have inherent vesicoureteral reflux that flushes urine from the bladder up into the kidneys, were susceptible to prolonged bacteriuria. This result is consistent with the fact that A. urinae infections most frequently occur in patients with underlying urinary tract abnormalities or disorders that make them susceptible to bacterial infection. Unlike uropathogens such as E. coli, which cause infection and inflammation both of the bladder and kidneys in C3H/HeN mice, A. urinae displayed tropism for the kidney, persisting in kidney tissue even after clearance of bacteria from the bladder. Aerococcus urinae strains from different genetic clades displayed varying propensities to cause persistent kidney infection. Aerococcus urinae infected kidneys displayed histological inflammation, neutrophil recruitment and increased pro-inflammatory cytokines. These results set the stage for future research that interrogates host-pathogen interactions between A. urinae and the urinary tract.


Sign in / Sign up

Export Citation Format

Share Document