scholarly journals FDG-PET Metabolic Vs CT Anatomical Monitoring of Tumor Response to Anterior Chemotherapy in Breast Carcinoma-The Uncertainties

Author(s):  
G Lohith
2010 ◽  
Vol 35 (12) ◽  
pp. 960-961 ◽  
Author(s):  
Ankur Pruthi ◽  
Sandip Basu ◽  
Subhash K. Ramani ◽  
Supreeta Arya

2004 ◽  
Vol 22 (5) ◽  
pp. 900-908 ◽  
Author(s):  
Hinrich A. Wieder ◽  
Björn L.D.M. Brücher ◽  
Frank Zimmermann ◽  
Karen Becker ◽  
Florian Lordick ◽  
...  

PurposeTo evaluate the time course of therapy-induced changes in tumor glucose use during chemoradiotherapy of esophageal squamous cell carcinoma (ESCC) and to correlate the reduction of metabolic activity with histopathologic tumor response and patient survival.Patients and MethodsThirty-eight patients with histologically proven intrathoracic ESCC (cT3, cN0/+, cM0) scheduled to undergo a 4-week course of preoperative simultaneous chemoradiotherapy followed by esophagectomy were included. Patients underwent positron emission tomography with the glucose analog fluorodeoxyglucose (FDG-PET) before therapy (n = 38), after 2 weeks of initiation of therapy (n = 27), and preoperatively (3 to 4 weeks after chemoradiotherapy; n = 38). Tumor metabolic activity was quantitatively assessed by standardized uptake values (SUVs).ResultsMean tumor FDG uptake before therapy was 9.3 ± 2.8 SUV and decreased to 5.7 ± 1.9 SUV 14 days after initiation of chemoradiotherapy (−38% ± 18%; P < .0001). The preoperative scan showed an additional decrease of metabolic activity to 3.3 ± 1.1 SUV (P < .0001). In histopathologic responders (< 10% viable cells in the resected specimen), the decrease in SUV from baseline to day 14 was 44% ± 15%, whereas it was only 21% ± 14% in nonresponders (P = .0055). Metabolic changes at this time point were also correlated with patient survival (P = .011). In the preoperative scan, tumor metabolic activity had decreased by 70% ± 11% in histopathologic responders and 51% ± 21% in histopathologic nonresponders.ConclusionChanges in tumor metabolic activity after 14 days of preoperative chemoradiotherapy are significantly correlated with tumor response and patient survival. This suggests that FDG-PET might be used to identify nonresponders early during neoadjuvant chemoradiotherapy, allowing for early modifications of the treatment protocol.


2016 ◽  
Vol 85 (5) ◽  
pp. 943-949 ◽  
Author(s):  
Kazuhiro Kitajima ◽  
Toshiko Yamano ◽  
Kazuhito Fukushima ◽  
Yasuo Miyoshi ◽  
Seiichi Hirota ◽  
...  

2021 ◽  
pp. 153677
Author(s):  
Danhui Zhao ◽  
Xin Fu ◽  
Joseph Rohr ◽  
Yingmei Wang ◽  
Mingyang Li ◽  
...  

2016 ◽  
Vol 35 (2) ◽  
pp. 81-87 ◽  
Author(s):  
A.M. García Vicente ◽  
A. Soriano Castrejón ◽  
R.E. Pruneda-González ◽  
G. Fernández Calvo ◽  
M.M. Muñoz Sánchez ◽  
...  

2018 ◽  
Vol 101 ◽  
pp. 65-71 ◽  
Author(s):  
Soichi Odawara ◽  
Kazuhiro Kitajima ◽  
Takayuki Katsuura ◽  
Yasunori Kurahashi ◽  
Hisashi Shinohara ◽  
...  

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Aziz Bazine ◽  
Mohamed Fetohi ◽  
Maha Ait Berri ◽  
Yacir Oufroukhi ◽  
Mohamed Ichou ◽  
...  

2019 ◽  
Vol 9 (2) ◽  
pp. 496-506 ◽  
Author(s):  
Xuejin Ou ◽  
Jing Zhang ◽  
Jian Wang ◽  
Fuwen Pang ◽  
Yongsheng Wang ◽  
...  

2018 ◽  
Vol 39 (11) ◽  
pp. 1033-1038 ◽  
Author(s):  
Tomoyuki Fujioka ◽  
Kazunori Kubota ◽  
Yuka Kikuchi ◽  
Junichi Tsuchiya ◽  
Ukihide Tateishi ◽  
...  

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