CUMULATIVE PROPERTIES OF THE NEW ANTI-MIGENOUS COMPOUND IN THE TABLET MEDICAL FORM

Cumulative properties of 2-metoxifenil-imidazobenzimidazole derivative (RU-31) in tablet medical form (8 mg) were studied for development of new drug for migraine treatment. Four-week experiments were carried out on white rats of both sex, with intragastral administration of RU-31 water solution in the doses of 10 mg/kg and 100 mg/kg. On the 29th day the dose of tested compound equal to LD50 was administered to the animals. Due to the calculation of accumulation coefficient(more than 20 units) the tablet form of RU-31 shows the lack of cumulative properties.

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Mandible Aseptic Osteonecrosis Caused by admission of the Narcotic Substances Containing Aminophosphonic Impurities: Levelling with Trilon B

Lesya Ukrainka Eastern European National University Scientific Bulletin Series Biological Sciences ◽

10.29038/2617-4723-2020-1-389-72-79 ◽

2020 ◽

Author(s):

S. Mostovoy ◽

V. Pikaluk ◽

K. Plekhanova ◽

M. Peshkov

Keyword(s):

Light Microscopy ◽

Bone Remodeling ◽

Water Solution ◽

Intragastric Administration ◽

White Rats ◽

Aseptic Osteonecrosis ◽

Functional Indices ◽

Mandible Structure

The aim of our study was to correct osteosclerotic changes (aseptic osteonecrotic lesion) of mandibular bones in laboratory white rats. Changes were caused by 1 and 3 monthly intragastric administration of amino phosphonic impurity. It was formed during artisanal manufacture of meta-amphetamine. A dose was 63 mg/kg 1 time per day, and followed by exposure to 5% water solution of Trilon B at a dose of 250 mg/kg. Mandible structure was researched by light microscopy. Three additional functional indices and elements of node-strut analysis were enrolled. Indices and their abbreviations were used in accordance to Committee on Histomorphometry Nomenclature (ASBMR). It was found that intragastric administration of Trilon B at a dose of 250 mg/kg after one-month- and three-month influence of amino phosphonic impurity (by-product of methamphetamine artisanal synthesis) at a dose of 63 mg/kg led to improvements of mandible bone remodeling. Also, enhancement of processes that removed osteosclerotic changes as well as an involution of myelofibrosis took place.

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