scholarly journals Global Burden of Animal Diseases: a novel approach to understanding and managing disease in livestock and aquaculture

2021 ◽  
Vol 40 (2) ◽  
pp. 567-584
Author(s):  
T.M. BERNARDO ◽  
M. BRUCE ◽  
J. RUSHTON ◽  
A.P. SHAW ◽  
D. GRACE ◽  
...  
Keyword(s):  
Global Burden ◽  
Animal Diseases ◽  
Novel Approach

Roll-out of the Global Burden of Animal Diseases programme

The Lancet ◽  
2021 ◽  
Vol 397 (10279) ◽  
pp. 1045-1046 ◽  
Author(s):  
J Rushton ◽  
B Huntington ◽  
W Gilbert ◽  
M Herrero ◽  
P R Torgerson ◽  
...  
Keyword(s):  
Global Burden ◽  
Animal Diseases ◽  
Roll Out

scholarly journals Global Burden of Animal Diseases – building a community of practice for animal health economics

2019 ◽  
Author(s):  
J. RUSHTON ◽  
T. BERNARDO ◽  
M. BRUCE ◽  
C. BELLET ◽  
P. TORGERSON ◽  
...  
Keyword(s):  
Health Economics ◽  
Community Of Practice ◽  
Animal Health ◽  
Global Burden ◽  
Animal Diseases

scholarly journals Integrating digital and field surveillance to complement efforts to manage epidemic diseases of livestock: African swine fever as a case study

2021 ◽  
Author(s):  
Michele Tizzani ◽  
Violeta Muñoz-Gómez ◽  
Marco De Nardi ◽  
Daniela Paolotti ◽  
Olga Muñoz ◽  
...  
Keyword(s):  
Information Seeking ◽  
Local Level ◽  
African Swine Fever ◽  
Population Level ◽  
Information Seeking Behavior ◽  
Public Attention ◽  
Digital Platforms ◽  
Animal Diseases ◽  
Novel Approach ◽  
Seeking Behavior

The SARS-CoV-2 pandemic has unveiled the importance of stakeholders and ordinary citizens in managing infectious disease emergencies. Efficient management of infectious diseases requires a top-down approach which must be complemented with a bottom-up response to be effective. Here we investigate a novel approach to surveillance for transboundary animal diseases using African Swine fever as a model. We were able to collect data at a population level on information-seeking behavior and at a local level through a targeted questionnaire-based survey to relevant stakeholders such as farmers and veterinary authorities. Our study shows how information-seeking behavior and resulting public attention during an epidemic, can be addressed through novel data streams from digital platforms such as Wikipedia. We also bring evidence on how field surveys aimed at local workers (e.g. farmers) and public authorities remain a crucial tool to assess more in-depth preparedness and awareness among front-line actors. We conclude that they should be used in combination to maximize the outcome of surveillance and prevention activities for selected transboundary animal diseases.

Initiation of Global Burden of Animal Diseases Programme

The Lancet ◽  
2018 ◽  
Vol 392 (10147) ◽  
pp. 538-540 ◽  
Author(s):  
Jonathan Rushton ◽  
Mieghan Bruce ◽  
Camille Bellet ◽  
Paul Torgerson ◽  
Alexandra Shaw ◽  
...  
Keyword(s):  
Global Burden ◽  
Animal Diseases

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

Abstract #709: E-Consults: A Novel Approach to Increase Access to Subspecialty Care in Endocrinology

2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
...  
Keyword(s):  
Novel Approach
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