scholarly journals LIPID METABOLISM DISORDERS IN PATIENTS WITH CHRONIC HEPATITIS C

2015 ◽  
pp. 50-56 ◽  
Author(s):  
L. I. Tkachenko ◽  
V. V. Maleev ◽  
D. M. Sarieva
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Viral Load ◽  
Lipid Metabolism ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hdl Cholesterol ◽  
Response To Treatment ◽  
Genotype 3 ◽  
Lipid Metabolism Disorders

Purpose of the study. To study lipid metabolism in chronic hepatitis C and to assess its impact on the formation of insulin resistance, steatosis and progression of liver fibrosis.Materials and methods. The study included 205 patients with chronic hepatitis C (CHC). Conducts research, depending on the genotype C, viral load and body mass index (BMI) of the patients.Results. CHC patients revealed a combined hyperlipoproteinemia on the background of op-pression synthesis of apolipoproteins A1 and B. Formation of hepatic steatosis was associated with HCV genotype 3 virus-induced viral load at ≥ 6 log10 IU/ml and metabolic in VL < 6 log10 IU/ml. In patients with chronic hepatitis C genotype 1, high viral load leads to inhibition of protein synthesis conveyor ApoA1 and increased synthesis of cholesterol, accompanied by abdominal obesity and the formation of insulin resistance. CHC patients with BMI < 25 kg/m2 viral load ≥ 6 log10 ME/ml was associated with dyslipidemia IV type on D. Fredriskson (1970), hyperglycemia, insulin resistance and diabetes. The advanced stage of liver fi brosis (F ≥ 3 on a scale METAVIR) and non-response to treatment were associated with a decrease in HDL cholesterol below normal. With an increase in viral load > 5 log10 ME/ml signifi cantly increased the risk of lipid and carbohydrate metabolism.

Association of insulin resistance, viral load, and adipokine levels with liver histology in patients with chronic hepatitis C

2012 ◽  
Vol 24 (12) ◽  
pp. 1393-1399 ◽  
Author(s):  
Hasan S. Zeki Aksu ◽  
Behice Kurtaran ◽  
Yusuf Onlen ◽  
Mustafa Namiduru ◽  
Ahmet C. Inkaya ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Histology

Should Pre-treatment Viral Load Determine Treatment Duration for Chronic Hepatitis C Genotype 3 Patients

2009 ◽  
Vol 104 ◽  
pp. S137
Author(s):  
John Cunningham ◽  
Matthew Bechtold ◽  
Srinivas Puli ◽  
Michelle Matteson ◽  
Manish Thapar
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Treatment Duration ◽  
Genotype 3 ◽  
Pre Treatment

scholarly journals Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Munechika Enjoji ◽  
Motoyuki Kohjima ◽  
Kazuhiro Kotoh ◽  
Makoto Nakamuta
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Lipid Metabolism ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Metabolic Disorders ◽  
Current Knowledge ◽  
Antiviral Treatment ◽  
Treatment Options ◽  
Hcv Infection

It has been reported that hepatitis C virus (HCV) infection is closely associated with hepatic metabolic disorders. Hepatic steatosis and insulin resistance are both relatively common in patients with chronic hepatitis C. Recent investigations suggest that HCV infection changes the expression profile of lipid-metabolism-associated factors in the liver, conferring advantages to the life cycle of HCV. Moreover, insulin resistance and steatosis are independent predictors of impaired response to antiviral treatment in chronic hepatitis C. In this paper, we summarize our current knowledge of hepatic metabolic disorders and describe how HCV leads to and exploits these hepatic disorders. We also discuss the clinical significance of insulin sensitizers used to improve insulin resistance and lipid modulators used to manage lipid metabolism as potential treatment options for chronic hepatitis C.

Insulin Resistance in Patients with Chronic Hepatitis C

2016 ◽  
Vol 70 (2) ◽  
pp. 93-98
Author(s):  
Beti Todorovska ◽  
Viktorija Caloska-Ivanova ◽  
Magdalena Dimitrova-Genadieva ◽  
Elena Curakova ◽  
Nenad Joksimovic
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Steatosis ◽  
Chronic Viral Hepatitis ◽  
Cross Sectional ◽  
Viral Hepatitis C ◽  
Treatment Naïve

Abstract Introduction. Insulin resistance is the most common extrahepatic manifestation associated with hepatitis C virus, which leads to developing more pronounced fibrosis and liver steatosis. The aim of the study was to assess the prevalence of insulin resistance in non-diabetic, treatment naive patients with chronic hepatitis C and to analyze the relation of insulin resistance with genotype, viral load, gender, age, laboratory parameters, inflammatory and fibrotic changes in the liver, body mass index (BMI) and the presence of steatosis. Methods. In this cross sectional study, 224 patients with hepatitis C viral infection were included. The patients were divided into two groups. The first group was with no insulin resistance and the second one with present insulin resistance. They were compared in terms of genotype, viral load, gender, age, inflammatory and fibrotic changes in the liver, BMI and liver steatosis. Results. Insulin resistance was present in 45.5% of patients. The following factors were associated with insulin resistance: age (p=0.0022), inflammatory and fibrotic changes in the liver (p=0.001, p=0.006, respectively), steatosis (p=0.015) and transaminase activities (for AST, p=0,002, for ALT, p=0.001). Conclusion. In the Republic of Macedonia, a high percent of 45.5% among non-diabetic and treatment naïve patients with chronic viral hepatitis C, had insulin resistance. Insulin resistance was more prevalent in older patients, in those with more pronounced inflammatory and fibrotic changes in the liver, in patients with steatosis and in those with higher transaminase activity.

Sign in / Sign up

Export Citation Format

Share Document