scholarly journals Gender aspects of mild cognitive impairment

2009 ◽  
Vol 8 (3(2)) ◽  
pp. 36-38
Author(s):  
N. I. Skulskaya ◽  
M. V. Nadezhdina ◽  
Ye. V. Osinceva ◽  
M. N. Zhezher
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Neuropsychological Tests ◽  
Long Term Memory ◽  
Men And Women ◽  
Term Memory ◽  
Gender Aspects

Neuropsychological research and analysis of level testosterone and estradiol among men and women at age from 50 to 60 were carried out. Two groups were formed. The first group was of patients with complaints bad memory and concentration, and the second group was of patients with out any complaints. The change for certain of results the neuropsychological tests between two groups of patients were fixed. The results of long-term memory were more sensible. The correlation between different level of testosterone and results of neuropsychological tests among men and women was fixed. The correlation between level of estradiol and results of neuropsychological tests was not fixed.

P1-464: Episodic long-term memory as a predictor of change from retrieval to storage memory profile in amnestic mild cognitive impairment

2011 ◽  
Vol 7 ◽  
pp. S262-S262
Author(s):  
Emma Rodriguez-Noriega ◽  
Mikel Olabarrieta ◽  
Francesc Pujadas ◽  
Marta Ibarria ◽  
Diana Liebana ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Long Term Memory ◽  
Term Memory

P2-309: Long-Term Memory Functioning in Age-Associated Memory Impairment and Mild Cognitive Impairment

2016 ◽  
Vol 12 ◽  
pp. P755-P755
Author(s):  
Rebecca Crean ◽  
Gary Kay ◽  
Donald Connor ◽  
Jamie Reiter ◽  
Joseph Djan ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Impairment ◽  
Long Term Memory ◽  
Term Memory ◽  
Memory Functioning

Altered neural network supporting declarative long-term memory in mild cognitive impairment

2009 ◽  
Vol 30 (2) ◽  
pp. 284-298 ◽  
Author(s):  
Katrin Poettrich ◽  
Peter H. Weiss ◽  
Annett Werner ◽  
Silke Lux ◽  
Markus Donix ◽  
...  
Keyword(s):  
Neural Network ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Long Term Memory ◽  
Term Memory

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

2010 ◽  
Vol 20 (22) ◽  
pp. 6387-6393 ◽  
Author(s):  
Michel Gallant ◽  
Renee Aspiotis ◽  
Stephen Day ◽  
Rebecca Dias ◽  
Daniel Dubé ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Loss ◽  
Pde4 Inhibitor ◽  
Long Term Memory ◽  
Term Memory

Benefits of training working memory in amnestic mild cognitive impairment: specific and transfer effects

2012 ◽  
Vol 25 (4) ◽  
pp. 617-626 ◽  
Author(s):  
Barbara Carretti ◽  
Erika Borella ◽  
Silvia Fostinelli ◽  
Michela Zavagnin
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fluid Intelligence ◽  
Amnestic Mild Cognitive Impairment ◽  
Control Group ◽  
Long Term Memory ◽  
Transfer Effects ◽  
Memory Problems

ABSTRACTBackground:A growing number of studies are attempting to understand how effective cognitive interventions may be for patients with amnestic mild cognitive impairment (aMCI), particularly in relation to their memory problems.Methods:The present study aimed to explore the benefits of a working memory (WM) training program in aMCI patients. Patients (N= 20) were randomly assigned to two training programs: the experimental group practiced with a verbal WM task, while the active control group conducted educational activities on memory.Results:Results showed that the aMCI patients completing the WM training obtained specific gains in the task trained with some transfer effects on other WM measures (visuospatial WM) and on processes involved in or related to WM, e.g. fluid intelligence (the Cattell test) and long-term memory. This was not the case for the aMCI control group, who experienced only a very limited improvement.Conclusion:This pilot study suggests that WM training could be a valuable method for improving cognitive performance in aMCI patients, possibly delaying the onset of Alzheimer's disease.

scholarly journals Paclitaxel Chemotherapy Induces Long-Term Memory Impairment and Neuroinflammation in a Mouse Model of Breast Cancer Survivorship

2021 ◽  
Author(s):  
Ni-Chun Chung ◽  
Aeson Chang ◽  
Ryan Gillis ◽  
Erica Sloan ◽  
Adam K Walker
Keyword(s):  
Cognitive Impairment ◽  
Memory Impairment ◽  
Cancer Surgery ◽  
Long Term Memory ◽  
Cumulative Impact ◽  
Term Memory ◽  
Maze Test ◽  
Y Maze ◽  
The Brain

Abstract BackgroundCancer-related cognitive impairment (CRCI) has been reported in cancer survivors 20 years or more after cancer treatment, and has been associated with sustained increases in circulating inflammatory biomarkers. One of the major risk factors for CRCI is chemotherapy, and preclinical studies typically examine the impact of chemotherapy in cancer naïve mice to evaluate potential mechanisms However, clinical evaluation of the long-term effects of chemotherapy cannot avoid the potential cumulative impact of preceding factors on the brain including the cancer itself and cancer surgery. MethodsTo evaluate the cumulative impact of cancer-related factors on cognitive impairment and hippocampal cytokine expression, we evaluated the effect of paclitaxel chemotherapy vs. placebo on a background of 67NR mammary carcinoma and surgical resection of the primary tumour in mice. Memory was assessed using the Y maze test and novel object/novel place recognition test. Changes in hippocampal pro-inflammatory and anti-inflammatory cytokines, microglia and neuron markers were assessed using qRT-PCR. Results Cancer and cancer surgery was sufficient to induce long-term memory impairment and sustained increases in hippocampal pro-inflammatory cytokines. Paclitaxel prolonged spatial memory impairment in the Y maze test and exacerbated hippocampal Il6 and Tnfa mRNA expression compared with placebo treatment. ConclusionsThese findings suggest that cancer and cancer surgery can sensitise the brain to an exaggerated neuroinflammatory response to chemotherapy, and may contribute to sustained chemotherapy-induced cognitive impairment observed in cancer survivors.

scholarly journals Sleep Deprivation Aggravates Cognitive Impairment by the Alteration of Hippocampal Neuronal Activity and the Density of Dendritic Spine in Isoflurane-Exposed Mice

2020 ◽  
Vol 14 ◽  
Author(s):  
Kai Zhang ◽  
Naqi Lian ◽  
Ran Ding ◽  
Cunle Guo ◽  
Xi Dong ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Sleep Deprivation ◽  
Dendritic Spines ◽  
Hippocampal Neurons ◽  
Short Term Memory ◽  
Elective Surgery ◽  
Long Term Memory ◽  
General Anesthetic ◽  
Term Memory

Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative SD exacerbates cognitive impairment induced by isoflurane. In this study, we observed the effects of pretreated 24-h SD in adult isoflurane-exposed mice on the cognitive behaviors, the Ca2+ signals of dorsal hippocampal CA1 (dCA1) neurons in vivo with fiber photometry, and the density of dendritic spines in hippocampal neurons. Our results showed that in cognitive behavior tasks, short-term memory damages were more severe with SD followed by isoflurane exposure than that with SD or isoflurane exposure separately, and interestingly, severe long-term memory deficits were induced only by SD followed by isoflurane exposure. Only the treatment of SD followed by isoflurane exposure could reversibly decrease the amplitude of Ca2+ signals when mice were freely moving and increase the duration of Ca2+ signals during the long-term memory behavior test. The density of dendritic spines with both SD and isoflurane exposure was lower than that with SD alone. This study suggests that SD should be avoided preoperatively in patients undergoing elective surgery under isoflurane anesthesia.

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