scholarly journals P3-402: NEURAL ACTIVATION OF THE ANTERIOR CINGULATE CORTEX PREDICTS SUBSEQUENT LONG-TERM MEMORY IN MILD COGNITIVE IMPAIRMENT DUE TO ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P1106-P1107
Author(s):  
Maximilian H.T. Schmieschek ◽  
Nils Nellessen ◽  
Paulo Lubaca ◽  
Nils Richter ◽  
Ronja Fassbender ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Long Term Memory ◽  
Neural Activation ◽  
Term Memory

P1-464: Episodic long-term memory as a predictor of change from retrieval to storage memory profile in amnestic mild cognitive impairment

2011 ◽  
Vol 7 ◽  
pp. S262-S262
Author(s):  
Emma Rodriguez-Noriega ◽  
Mikel Olabarrieta ◽  
Francesc Pujadas ◽  
Marta Ibarria ◽  
Diana Liebana ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Long Term Memory ◽  
Term Memory

Reduced Thickness of the Anterior Cingulate Cortex as a Predictor of Amnestic-Mild Cognitive Impairment Conversion to Alzheimer’s Disease with Psychosis

2021 ◽  
pp. 1-9
Author(s):  
Hee-Jeong Jeong ◽  
Young-Min Lee ◽  
Je-Min Park ◽  
Byung-Dae Lee ◽  
Eunsoo Moon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cortical Thickness ◽  
Cingulate Cortex ◽  
Amnestic Mild Cognitive Impairment ◽  
Anterior Cingulate ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

Background: A long-term follow-up study in patients with amnestic mild cognitive impairment (aMCI) is needed to elucidate the association between regional brain volume and psychopathological mechanisms of Alzheimer’s disease with psychosis (AD + P). Objective: The purpose of this study was to investigate the effect of the thickness of the angular cingulate cortex (ACC) on the risk of AD + P conversion in patients with aMCI. Methods: This was a hospital-based prospective longitudinal study including 174 patients with aMCI. The main outcome measure was time-to-progression from aMCI to AD + P. Subregions of the ACC (rostral ACC, rACC; caudal ACC, cACC) and hippocampus (HC) were measured as regions of interest with magnetic resonance imaging and the Freesurfer analysis at baseline. Survival analysis with time to incident AD + P as an event variable was calculated with Cox proportional hazards models using the subregions of the ACC and HC as a continuous variable. Results: Cox proportional hazard analyses showed that the risk of AD + P was associated with sub-regional ACC thickness but not HC volume: reduced cortical thickness of the left cACC (HR [95%CI], 0.224 [0.087–0.575], p = 0.002), right cACC (HR [95%CI], 0.318 [0.132–0.768], p = 0.011). This association of the cACC with the risk of AD also remained significant when adjusted for HC volume. Conclusion: We found that reduced cortical thickness of the cACC is a predictor of aMCI conversion to AD + P, independent of HC, suggesting that the ACC plays a vital role in the underlying pathogenesis of AD + P.

scholarly journals Gender aspects of mild cognitive impairment

2009 ◽  
Vol 8 (3(2)) ◽  
pp. 36-38
Author(s):  
N. I. Skulskaya ◽  
M. V. Nadezhdina ◽  
Ye. V. Osinceva ◽  
M. N. Zhezher
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Neuropsychological Tests ◽  
Long Term Memory ◽  
Men And Women ◽  
Term Memory ◽  
Gender Aspects

Neuropsychological research and analysis of level testosterone and estradiol among men and women at age from 50 to 60 were carried out. Two groups were formed. The first group was of patients with complaints bad memory and concentration, and the second group was of patients with out any complaints. The change for certain of results the neuropsychological tests between two groups of patients were fixed. The results of long-term memory were more sensible. The correlation between different level of testosterone and results of neuropsychological tests among men and women was fixed. The correlation between level of estradiol and results of neuropsychological tests was not fixed.

P2-309: Long-Term Memory Functioning in Age-Associated Memory Impairment and Mild Cognitive Impairment

2016 ◽  
Vol 12 ◽  
pp. P755-P755
Author(s):  
Rebecca Crean ◽  
Gary Kay ◽  
Donald Connor ◽  
Jamie Reiter ◽  
Joseph Djan ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Impairment ◽  
Long Term Memory ◽  
Term Memory ◽  
Memory Functioning

scholarly journals Diagnostic power of resting-state fMRI for detection of network connectivity in Alzheimer's disease and Mild Cognitive Impairment: A systematic review

2020 ◽  
Author(s):  
BUHARI IBRAHIM ◽  
Nisha Syed Nasser ◽  
NORMALA IBRAHIM ◽  
Mazlyfarina Mohamed ◽  
Hasyma Abu Hassan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Resting State ◽  
Cingulate Cortex ◽  
Resting State Fmri ◽  
Anterior Cingulate ◽  
Healthy Controls ◽  
Diagnostic Power

Resting state fMRI (rs-fMRI) detects functional connectivity (FC) abnormalities that occur in the brains of patients with Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). FC of the default mode network (DMN), which is involved in memory consolidation, is commonly impaired in AD and MCI. We aimed to determine the diagnostic power of rs-fMRI to identify FC abnormalities in the DMN, which help to distinguish patients with AD or MCI from healthy controls (HCs). We searched articles in PubMed and Scopus databases using the search terms such as AD, MCI, resting-state fMRI, sensitivity and specificity through to 27th March 2020 and removed duplicate papers. We screened 390 published articles, and shortlisted 12 articles for the final analysis. The range of sensitivity of DMN FC at the posterior cingulate cortex (PCC) for diagnosing AD was between 65.7% - 100% and specificity ranged from 66 - 95%. Reduced DMN FC between the PCC and anterior cingulate cortex (ACC) in the frontal lobes was observed in MCI patients. AD patients had impaired FC in most regions of the DMN; particularly the PCC in early AD. This indicates that DMN's rs-fMRI FC can offer moderate to high diagnostic power to distinguish AD and MCI patients. fMRI detected abnormal DMN FC, particularly in the PCC that helps to differentiate AD and MCI patients from healthy controls (HCs). Combining multivariate method of analysis with other MRI parameters such as structural changes improve the diagnostic power of rs-fMRI in distinguishing patients with AD or MCI from HCs.

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