scholarly journals Deteksi Kurkumin dan Bisdemetoksikurkumin dengan Teknik Voltammetri Menggunakan Elektrode Boron-Doped Diamond

2018 ◽  
Vol 14 (2) ◽  
pp. 253
Author(s):  
Wulan Tri Wahyuni ◽  
Latifah Kosim Darusman ◽  
Yuris Diksy
Keyword(s):  
Simultaneous Detection ◽  
Oxidation Peak ◽  
Optimum Conditions ◽  
Boron Doped Diamond ◽  
Oxidation Peak Current ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Boron Doped Diamond Electrode ◽  
Cyclic Voltammetry Method ◽  
Voltammetric Technique

<p>Pada penelitian ini metode deteksi kurkumin dan bisdemetoksikurkumin dikembangkan dengan teknik voltammetri siklik menggunakan elektrode <em>boron-doped diamond</em>. Voltammogram siklik kurkumin dan bisdemetoksikurkumin dalam larutan elektrolit tetrabutilamonium heksafluorofosfat (TBAPF<sub>6</sub>)-asetonitril masing-masing menunjukkan 2 puncak oksidasi, yaitu pada potensial +0,4 V dan +1,9 V vs. Ag/AgCl untuk kurkumin, serta +0,6 V dan +2,0 V vs. Ag/AgCl untuk bisdemetoksikurkumin. Hubungan linear diperoleh antara konsentrasi kurkumin maupun bisdemetoksikurkumin dengan arus puncak oksidasinya. Hubungan linear  yang diperoleh adalah <em>I</em>(µA) = 8619,9C (M) + 0,7285 (<em>R<sup>2</sup></em>=0,9995) dan <em>I</em>(µA) = 14658C (M) + 16,388 (<em>R<sup>2</sup></em>=0,9299) berturut-turut untuk kurkumin puncak pertama dan kedua, serta <em>I</em>(µA) = 7953,2C (M) + 5,3977 (<em>R<sup>2</sup></em>=0,9871) dan <em>I</em>(µA) = 5807,7 C (M) + 7,7616 (<em>R<sup>2</sup></em>=0,9981) untuk bisdemetoksikurkumin puncak pertama dan kedua. Aplikasi metode yang dikembangkan terhadap sampel buatan yang mengandung campuran kurkumin dan bisdemetoksikurkumin menghasilkan 3 puncak oksidasi pada potensial +0,3 V, +1,2 V, dan +2,0 V vs Ag/AgCl mengindikasikan terjadinya tumpang tindih antara puncak kurkumin dan BDMC serta pergeseran puncak oksidasi. Nilai presisi pengukuran dengan metode yang dikembangkan ialah 15,86 dan 15,15% untuk kurkumin, serta 9,85 dan 31,47% untuk bisdemetoksikurkumin. Sementara nilai akurasi pengukuran ialah sebesar 96,69 dan 125,36% untuk kurkumin, serta 97,95 dan 127,54% untuk bisdemetoksikurkumin masing-masing berdasarkan puncak 1 dan 2. Hasil yang diperoleh menunjukkan performa analitik metode yang dikembangkan masih perlu ditingkatkan sebelum diaplikasikan untuk analisis kuantitatif.</p><p align="left"><strong>Detection of Curcumin and Bisdemetoxycurcumin by Voltammetric Technique using a Boron-Doped Diamond Electrode.</strong>  This study develops a cyclic voltammetry method for simultaneous detection of curcuminoid by using boron-doped diamond electrode. Curcumin and bisdemethoxycurcumin (BDMC) in tetrabutylammonium hexafluorophosphate (TBAPF<sub>6</sub>)-acetonitrile as electrolyte solution showed two oxidation peaks at +0.4 V and +1.9 V for curcumin, while those for BDMC appeared at +0.6 V and +2.0 V. Reduction peaks of both standards were not observed. In the optimum conditions, this method showed linear correlation between concentration of curcumin and BDMC with it’s oxidation peak current. The equations of <em>I</em>(µA) = 8619.9(C) (M) + 0.7285 (<em>R<sup>2</sup></em>=0,9995) and <em>I</em>(µA) = 14658(C) (M) + 16.388 (<em>R<sup>2</sup></em>=0.9299) were obtained for curcumin, <em>I</em>(µA) = 7953.2(C) (M) + 5.3977 (<em>R<sup>2</sup></em>=0,9871) and <em>I</em>(µA) = 5807.7(C) (M) + 7.7616 (<em>R<sup>2</sup></em>=0.9981) for BDMC. Meanwhile, the measurement of the artificial samples containing a mixture of curcumin and BDMC showed three oxidation peaks at +0.3 V, +1.2 V, and +2.0 V. This result indicated an overlapping between curcumin and BDMC peaks and peak shifting. Precision of the developed method was expressed as percent RSD, giving value of 15.86 and 15.15% for curcumin, and 9.85 and 31.47% for BDMC. The accuracy was 96.69 and 125.36% for curcumin, meanwhile for BDMC was 97.95 and 127.54% for peak 1 and 2. The result indicated that the method required further improvement before applied for quantitative analysis.</p>

scholarly journals The Use of Boron-Doped Diamond Electrode for the Determination of Selected Biocides in Water Samples

Water ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1595 ◽  
Author(s):  
Mielech-Łukasiewicz ◽  
Starczewska
Keyword(s):  
Water Samples ◽  
Square Wave Voltammetry ◽  
Boron Doped Diamond ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Wave Voltammetry ◽  
Boron Doped Diamond Electrode ◽  
Relative Standard ◽  
Cyclic Voltammetry Method

In recent years, the remains of chemical substances in water environments, referred to as emerging organic contaminations, have been more and more often studied by analysts. This work shows the possibility of using a boron-doped diamond electrode to determine low concentration levels of remains of pharmaceuticals in environmental samples. The study focused on selected biocides from the group of azole fungicides (itraconazole and posaconazole) and was performed using quick and sensitive electrochemical methods. The cyclic voltammetry method was used in order to determine the properties of these compounds, whereas analytical characterization was performed using square wave voltammetry. The work involved the specification of the optimum electrooxidation conditions of the selected fungicides, their comparative characterization, and the development of a new, sensitive methods of itraconazole and posaconazole assay. The proposed procedures allowed us to determine itraconazole in the range from 7.9 × 10−8 to 1.2 × 10−6 moL·L−1 and posaconazole in the range from 5.7 × 10−8 to 8.44 × 10−7 moL·L−1. The relative standard deviation of the measurements did not exceed 5.85%. The developed procedures were successfully used to determine itraconazole and posaconazole concentration in water samples and the assay recovery was between 93.5% and 102.8%.

scholarly journals Voltammetric quantification of an anesthetic drug propofol (2,6-diisopropylphenol) on boron-doped diamond electrode in the pharmaceutical formulations

2021 ◽  
pp. 17-17
Author(s):  
Ertuğrul Keskin ◽  
Shabnam Allahverdiyeva ◽  
Hande Özok ◽  
Oruç Yunusoğlu ◽  
Yavuz Yardim
Keyword(s):  
Pharmaceutical Formulations ◽  
Oxidation Peak ◽  
Boron Doped Diamond ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Diffusion Controlled ◽  
Boron Doped Diamond Electrode ◽  
Oxidation Wave ◽  
Pharmaceutical Sample ◽  
And Diffusion

In this paper, the detailed electrochemistry of propofol (PRO) which is one of the intravenous agents commonly used for sedative-hypnotic purposes was examined. In cyclic voltammetry, the agent showed one irreversible and diffusion?controlled oxidation peak, resulting in the formation of a couple with a reduction and re-oxidation wave at less positive potentials. The effect of electrode pretreatment procedures on the electrochemical response of PRO was investigated by using square wave voltammetry (SWV) and the optimum procedure was used to improve the signal response in subsequent studies. Quantification of PRO was done based on the first oxidation peak using SWV. After optimization of all variables, the linear working range of PRO was found to be between 2.5 ?g mL-1 (1.4?10-5 mol L-1) and 160.0 ?g mL-1 (1.1?10-3 mol L-1, n=15) with a detection limit 0.71 ?g mL-1 (3.9?10-6 mol L-1). No noteworthy interference effect was detected. Also, the developed method was used for quantification of PRO in pharmaceutical sample.

scholarly journals Micro-band Boron-doped Diamond Electrode in Capillary Electrophoresis for Simultaneous Detection of AMP, ADP, and ATP

2021 ◽  
Vol 12 (2) ◽  
pp. 252
Author(s):  
Putu Udiyani Prayikaputri ◽  
Prastika Krisma Jiwanti ◽  
Mochammad Arfin Fardiansyah Nasution ◽  
Jarnuzi Gunlazuardi ◽  
Endang Saepudin ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Simultaneous Detection ◽  
Boron Doped Diamond ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Boron Doped Diamond Electrode

scholarly journals Determination of tramadol in pharmaceutical forms and urine samples using a boron-doped diamond electrode

2020 ◽  
Vol 85 (7) ◽  
pp. 923-937
Author(s):  
Ertuğrul Keskin ◽  
Shabnam Allahverdiyeva ◽  
Esma Şeyho ◽  
Yavuz Yardim
Keyword(s):  
Sodium Dodecyl ◽  
Pharmaceutical Formulations ◽  
Open Circuit ◽  
Urine Samples ◽  
Oxidation Peak ◽  
Boron Doped Diamond ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Boron Doped Diamond Electrode

The present work describes the electroanalytical investigation and a novel voltammetric method for the cheap, fast and simple quantification of tramadol (TRH) using a boron-doped diamond electrode. TRH displayed one well-defined, irreversible and adsorption-controlled oxidation peak at about 1.58 V (vs. Ag/AgCl) in Britton?Robinson buffer (BR, 0.1 mol L-1, pH 3.0) using the cyclic voltammetry technique. The voltammetric responses of the oxidation peaks are dependent on pH and their sensitivity was significantly enhanced in the presence of surfactant media (sodium dodecyl sulphate, SDS). Under the optimized experiment conditions, employing the square-wave stripping mode, it was found that there was an excellent correlation between oxidation peak current and the TRH concentration in the range 0.25 to 50.0 ?g mL-1 (8.34?10-7?1.67?10-4 mol L-1), with a detection limit of 0.072 ?g mL-1 (2.40?10-7 mol L-1) in 0.1 mol L-1 BR buffer (pH 3.0) solution comprising 8?10-4 mol L-1 SDS at 1.52 V (after 30 s accumulation at open-circuit conditions). The developed approach could be used for the quantification of TRH in pharmaceutical formulations and spiked human urine samples with acceptable recoveries.

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