Developing Deep-Learning Methods for Diagnosis and Prognosis of Pediatric Progressive Diseases Using Modern Imaging Techniques

2021 ◽  
Author(s):  
◽  
Mahdieh Shabanian ◽  
Keyword(s):  
Machine Learning ◽  
Neural Networks ◽  
Image Analysis ◽  
Deep Learning ◽  
Neurological Disease ◽  
Medical Image ◽  
Medical Image Analysis ◽  
Disease State ◽  
Institutional Review Board ◽  
Institutional Review

Purpose and Rationale. Central nervous system manifestations form a significant burden of disease in young children. There have been efforts to correlate the neurological disease state in tuberous sclerosis complex (TSC) neurological disease state with imaging findings is a standard part of patient care. However, such analysis of neuroimaging is time- and labor-intensive. Automated approaches to these tasks are needed to improve speed, accuracy, and availability. Automated medical image analysis tools based on 3D/2D deep learning algorithms can help improve the quality and consistency of image diagnosis and interpretation for cognitive disorders in infants. We propose to automate neuroimaging analysis with artificial intelligence algorithms. This novel approach can be used to improve the accuracy of TSC diagnosis and treatment. Deep learning (DL) is among the most successful types of machine learning and utilizes deep artificial neural networks (ANNs), which can determine efficient feature representations of input data. DL algorithms have created new opportunities in medical image analysis. Applications of DL, specifically convolutional neural networks (CNNs), in medical image analysis, cover a broad spectrum of tasks, including risk prediction/estimation with a machine learning system trained on these classification tasks. Study population. We reviewed an NIMH Data Archive (NDA) dataset that was collected in 2010. We also reviewed imaging data from patients and normal cases from birth to 8 years of age acquired at Le Bonheur Children’s Hospital from 2014 to 2020. The University of Tennessee Health Science Center Institutional Review Board (IRB) approved this study. Research Design and Study Procedures. Following Institutional Review Board (IRB) approval, this thesis: 1) Presents the first 2D/3D fusion CNN models to estimate the age of infants from birth to 3 years of age. 2) Presents the first work to look at whole-brain network to automatically distinguish TSC brain structural pathology from normal cases using a 3DCNN model. Conclusions. The study findings indicate that deep neural networks tackle the problem of early prediction of cognitive and neurodevelopmental disorders and structural brain pathology based on MRI automatically in TSC children. It is the hope of the author that analysis of MRI images via methods of deep learning will have a positive impact on healthcare for infants and children at risk of rare diseases.

scholarly journals A Survey on Adversarial Deep Learning Robustness in Medical Image Analysis

Electronics ◽  
2021 ◽  
Vol 10 (17) ◽  
pp. 2132
Author(s):  
Kyriakos D. Apostolidis ◽  
George A. Papakostas
Keyword(s):  
Neural Networks ◽  
Image Analysis ◽  
Deep Learning ◽  
Language Processing ◽  
Medical Image ◽  
Medical Image Analysis ◽  
Attack Detection ◽  
Detection Methods ◽  
Proper Function ◽  
Magnetic Resonance Imaging Mri

In the past years, deep neural networks (DNN) have become popular in many disciplines such as computer vision (CV), natural language processing (NLP), etc. The evolution of hardware has helped researchers to develop many powerful Deep Learning (DL) models to face numerous challenging problems. One of the most important challenges in the CV area is Medical Image Analysis in which DL models process medical images—such as magnetic resonance imaging (MRI), X-ray, computed tomography (CT), etc.—using convolutional neural networks (CNN) for diagnosis or detection of several diseases. The proper function of these models can significantly upgrade the health systems. However, recent studies have shown that CNN models are vulnerable under adversarial attacks with imperceptible perturbations. In this paper, we summarize existing methods for adversarial attacks, detections and defenses on medical imaging. Finally, we show that many attacks, which are undetectable by the human eye, can degrade the performance of the models, significantly. Nevertheless, some effective defense and attack detection methods keep the models safe to an extent. We end with a discussion on the current state-of-the-art and future challenges.

scholarly journals Medical Imaging using Deep Learning Models

2021 ◽  
Vol 6 (5) ◽  
pp. 156-167
Author(s):  
Chetanpal Singh
Keyword(s):  
Neural Networks ◽  
Image Analysis ◽  
Deep Learning ◽  
Medical Imaging ◽  
Medical Image ◽  
Potential Role ◽  
Medical Image Analysis ◽  
Learning Models ◽  
Quality Healthcare ◽  
Learning Techniques

Deep learning has played a potential role in quality healthcare with fast automated and proper medical image analysis. In clinical applications, medical imaging is one of the most important parameters as with the help of this; experts can detect, monitor, and diagnose any kind of problems that are there in the patient's body. However, there are two things that one needs to understand; that is, the implementation of Artificial Neural Networks and Convolutional Neural Networks as well as deep learning to know about medical image analysis. It is necessary to state here that the deep learning approach is gaining attention in the medical imaging field in evaluating the presence or absence of disease in a patient. Mammography images, digital histopathology images, computerized tomography, etc. are some of the areas on which DL implementation focuses. One upon going through the paper will get to know the recent development that has occurred in this field and come up with a critical review on this aspect. The paper has demonstrated in detail modern deep learning models that are implemented in medical image analysis. There is no doubt about the promising future of the deep learning models and according to experts; the implementation of deep learning techniques has outperformed medical experts in numerous tasks. However, deep learning also has some drawbacks and challenges that are required to be addressed like limited datasets and many more. To mitigate such kinds of challenges, researchers are working on this aspect so that they can enhance healthcare by deploying AI.

scholarly journals Survey of Machine Learning Applications of Convolutional Neural Networks to Medical Image Analysis

2021 ◽  
Vol 9 (11) ◽  
pp. 1186-1196
Author(s):  
Dr. K. Naveen Kumar
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Computer Vision ◽  
Image Analysis ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Medical Image ◽  
Medical Image Analysis ◽  
Learning Techniques ◽  
Before And After

Abstract: Recently, a machine learning (ML) area called deep learning emerged in the computer-vision field and became very popular in many fields. It started from an event in late 2012, when a deep-learning approach based on a convolutional neural network (CNN) won an overwhelming victory in the best-known worldwide computer vision competition, ImageNet Classification. Since then, researchers in many fields, including medical image analysis, have started actively participating in the explosively growing field of deep learning. In this paper, deep learning techniques and their applications to medical image analysis are surveyed. This survey overviewed 1) standard ML techniques in the computer-vision field, 2) what has changed in ML before and after the introduction of deep learning, 3) ML models in deep learning, and 4) applications of deep learning to medical image analysis. The comparisons between MLs before and after deep learning revealed that ML with feature input (or feature-based ML) was dominant before the introduction of deep learning, and that the major and essential difference between ML before and after deep learning is learning image data directly without object segmentation or feature extraction; thus, it is the source of the power of deep learning, although the depth of the model is an important attribute. The survey of deep learningalso revealed that there is a long history of deep-learning techniques in the class of ML with image input, except a new term, “deep learning”. “Deep learning” even before the term existed, namely, the class of ML with image input was applied to various problems in medical image analysis including classification between lesions and nonlesions, classification between lesion types, segmentation of lesions or organs, and detection of lesions. ML with image input including deep learning is a verypowerful, versatile technology with higher performance, which can bring the current state-ofthe-art performance level of medical image analysis to the next level, and it is expected that deep learning will be the mainstream technology in medical image analysis in the next few decades. “Deep learning”, or ML with image input, in medical image analysis is an explosively growing, promising field. It is expected that ML with image input will be the mainstream area in the field of medical image analysis in the next few decades. Keywords: Deep learning, Convolutional neural network, Massive-training artificial neural network, Computer-aided diagnosis, Medical image analysis, Classification (key words)

scholarly journals A Tour of Unsupervised Deep Learning for Medical Image Analysis

2021 ◽  
Vol 17 ◽  
Author(s):  
Khalid Raza ◽  
Nripendra Kumar Singh
Keyword(s):  
Machine Learning ◽  
Image Analysis ◽  
Deep Learning ◽  
Medical Image ◽  
Medical Images ◽  
Medical Image Analysis ◽  
Heterogeneous Data ◽  
Learning Techniques ◽  
Deep Boltzmann Machine ◽  
Unsupervised Deep Learning

Background: Interpretation of medical images for the diagnosis and treatment of complex diseases from high-dimensional and heterogeneous data remains a key challenge in transforming healthcare. In the last few years, both supervised and unsupervised deep learning achieved promising results in the area of medical image analysis. Several reviews on supervised deep learning are published, but hardly any rigorous review on unsupervised deep learning for medical image analysis is available. Objectives: The objective of this review is to systematically present various unsupervised deep learning models, tools, and benchmark datasets applied to medical image analysis. Some of the discussed models are autoencoders and its other variants, Restricted Boltzmann machines (RBM), Deep belief networks (DBN), Deep Boltzmann machine (DBM), and Generative adversarial network (GAN). Further, future research opportunities and challenges of unsupervised deep learning techniques for medical image analysis are also discussed. Conclusion: Currently, interpretation of medical images for diagnostic purposes is usually performed by human experts that may be replaced by computer-aided diagnosis due to advancement in machine learning techniques, including deep learning, and the availability of cheap computing infrastructure through cloud computing. Both supervised and unsupervised machine learning approaches are widely applied in medical image analysis, each of them having certain pros and cons. Since human supervisions are not always available or inadequate or biased, therefore, unsupervised learning algorithms give a big hope with lots of advantages for biomedical image analysis.

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