scholarly journals The efficacy of Roxadustat for the treatment of anemia in dialysis dependent chronic kidney disease patients: an updated systematic review and meta-analysis of randomized clinical trials

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Basel Abdelazeem ◽  
Kirellos Said Abbas ◽  
Joseph Shehata ◽  
Nahla Ahmed El-Shahat ◽  
Nischit Baral ◽  
...  
2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Francini Porcher Andrade ◽  
Patrícia de Souza Rezende ◽  
Tatiane de Souza Ferreira ◽  
Gabrielle Costa Borba ◽  
Alice Mânica Müller ◽  
...  

AbstractPatients with chronic kidney disease show poorer functional and cardiorespiratory capacity than healthy individuals, and these impairments result in sedentarism. The aim of this study was to conduct a systematic review and meta-analysis of randomized clinical trials on the effects of different intradialytic exercise protocols on cardiopulmonary capacity in chronic kidney disease patients. The primary outcome was peak oxygen consumption (VO2peak) and the secondary outcomes were exercise duration and ventilation in the cardiopulmonary test. The quality of the evidence was evaluated using the GRADE guidelines. Seven studies with a total of 124 participants met the inclusion criteria. Compared to the non-exercise group, the exercise group improved in mean VO2peak (MD 4.06 [IC 0.81; 7.31]). In a separate analysis according to exercise modality, aerobic exercise plus strength training performed better than aerobic exercise alone (MD 5.28 [IC 3.90; 6.66]). In the exercise group, both exercise tolerance values (MD 3.10 [IC 1.70; 4.51]) and ventilation values in the cardiopulmonary test were better than those of the control group (MD 13.10 [IC 7.12; 19.09]). Thus, intradialytic exercise protocols can improve cardiopulmonary function, exercise tolerance and ventilatory efficiency in chronic kidney disease patients.


2018 ◽  
Vol 40 (3) ◽  
pp. 278-286 ◽  
Author(s):  
Raquel Aparecida Bandeira Fagundes ◽  
Taís Fátima Soder ◽  
Kamila Castro Grokoski ◽  
Fábia Benetti ◽  
Roberta Hack Mendes

ABSTRACT Chronic kidney disease (CKD) is a syndrome caused by the progressive reduction of renal function. This study aimed to systematically examine the effects of supplementation with probiotics in the treatment of CKD. Searches were carried out on databases MEDLINE (PubMed), SciELO, Cochrane, and Clinical Trials. Two independent reviewers selected the studies from which data was extracted. The search included papers written in English and Portuguese published in the 2012-2016 period describing randomized clinical trials. Eight of the 82 eligible articles met the inclusion criteria. Sample size ranged from 18 to 101 individuals with CKD. The duration of the included studies varied from four to 24 weeks. Most of the included articles reported positive effects in renal function and decreased levels of urea, blood urea nitrogen, ammonia, plasma p-cresol, p-cresyl sulfate, and indoxyl sulfate.


Nephron ◽  
2017 ◽  
Vol 136 (2) ◽  
pp. 85-94 ◽  
Author(s):  
Simon R. Walker ◽  
Paul Komenda ◽  
Suhail Khojah ◽  
Wafa Al-Tuwaijri ◽  
Kerry MacDonald ◽  
...  

Nutrients ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 732 ◽  
Author(s):  
Carlo Garofalo ◽  
Silvio Borrelli ◽  
Michele Provenzano ◽  
Toni De Stefano ◽  
Carlo Vita ◽  
...  

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii56-iii56
Author(s):  
Suetonia Palmer ◽  
Jasjot Maggo ◽  
Katrina Campbell ◽  
Jonathan Craig ◽  
David Johnson ◽  
...  

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