scholarly journals Left atrial appendage closure: prevalence and risk of device-associated thrombus formation

2019 ◽  
Vol 9 (1) ◽  
pp. 104-109
Author(s):  
Stefan Bertog ◽  
Horst Sievert
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Thrombus Formation ◽  
Atrial Appendage ◽  
Left Atrial Appendage Closure

scholarly journals Left Atrial Appendage Closure Devices

2014 ◽  
Vol 8 ◽  
pp. CMC.S14043 ◽  
Author(s):  
Jorge Romero ◽  
Irving E. Perez ◽  
Andrew Krumerman ◽  
Mario J. Garcia ◽  
Richard J. Lucariello
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Medical Literature ◽  
Thrombus Formation ◽  
Standard Of Care ◽  
Atrial Appendage ◽  
Thromboembolic Stroke ◽  
Left Atrial Appendage Closure ◽  
Alternative Therapeutic Approach ◽  
Safety Studies

Atrial fibrillation (AF) increases the risk for thromboembolic stroke five-fold. The left atrial appendage (LAA) has been shown to be the main source of thrombus formation in the majority of strokes associated with AF. Oral anticoagulation with warfarin and novel anticoagulants remains the standard of care; however, it has several limitations, including bleeding and poor compliance. Occlusion of the LAA has been shown to be an alternative therapeutic approach to drug therapy. The purpose of this article is to review the different techniques and devices that have emerged for the purpose of occluding this structure, with a particular emphasis on the efficacy and safety studies published to date in the medical literature.

Predictors of thrombus formation after percutaneous left atrial appendage closure using the WATCHMAN device

2017 ◽  
Vol 32 (9) ◽  
pp. 1137-1143 ◽  
Author(s):  
Hidehiro Kaneko ◽  
Michael Neuss ◽  
Jens Weissenborn ◽  
Christian Butter
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Thrombus Formation ◽  
Atrial Appendage ◽  
Left Atrial Appendage Closure ◽  
Watchman Device

scholarly journals Management of ascending aorta perforation during transseptal puncture for left atrial appendage closure: a case report

2021 ◽  
Vol 5 (4) ◽  
Author(s):  
Nili Schamroth Pravda ◽  
Pablo Codner ◽  
Hana Vaknin Assa ◽  
Rafael Hirsch
Keyword(s):  
Myocardial Infarction ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Thrombus Formation ◽  
Oral Anticoagulant Therapy ◽  
Ascending Aorta ◽  
Atrial Appendage ◽  
Transseptal Puncture ◽  
Left Atrial Appendage Closure ◽  
Protamine Sulphate

Abstract Background An 82-year-old female with a history of atrial fibrillation and repeated episodes of major bleeding on direct oral anticoagulant therapy, with a high risk for thromboembolism and was referred for left atrial appendage closure. Case summary During the procedure, an unrecognized puncture of the aorta by the transseptal puncture (TSP) needle and inadvertent advancement of the sheath resulted in ascending aorta perforation. This perforation was closed percutaneously using an Amplatzer™ Duct Occluder (ADO). Reversal of heparinization with protamine sulphate was given to avoid intractable bleeding. However, this resulted in thrombus formation and subsequent embolization causing an ST-elevation myocardial infarction. This was treated with balloon dilatation and thrombus aspiration with subsequent Thrombolysis in Myocardial Infarction 3 flow. Discussion Inadvertent ascending aorta perforation is a rare yet serious complication that can occur during TSP. Percutaneous closure using an ADO is a viable management option. The reversal of heparin carries a risk of thrombus formation and should be avoided in cases where there is no evidence of overt bleeding.

scholarly journals Thrombus Formation on a Left Atrial Appendage Closure Device

Circulation ◽  
2011 ◽  
Vol 124 (14) ◽  
pp. 1595-1596 ◽  
Author(s):  
Lorette Cardona ◽  
Galrinho Ana ◽  
Branco Luísa ◽  
Ana Leal ◽  
Fiarresga António ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Thrombus Formation ◽  
Atrial Appendage ◽  
Closure Device ◽  
Left Atrial Appendage Closure

scholarly journals Impact of Left Atrial Appendage Closure on LAA Thrombus Formation and Thromboembolism After LAA Isolation

2020 ◽  
Vol 6 (13) ◽  
pp. 1687-1697
Author(s):  
Thomas Fink ◽  
Julia Vogler ◽  
Christian-Hendrik Heeger ◽  
Makoto Sano ◽  
Vanessa Sciacca ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Thrombus Formation ◽  
Atrial Appendage ◽  
Left Atrial Appendage Closure

scholarly journals Large extracellular vesicles in the left atrial appendage in patients with atrial fibrillation—the missing link?

2021 ◽  
Author(s):  
Andreas Zietzer ◽  
Baravan Al-Kassou ◽  
Paul Jamme ◽  
Verena Rolfes ◽  
Eva Steffen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Extracellular Vesicles ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Thrombus Formation ◽  
Flow Cytometric Analysis ◽  
Heart Rhythm ◽  
Atrial Appendage ◽  
Peripheral Embolization

AbstractAtrial fibrillation (AF) is the most frequent arrhythmic disease in humans, which leads to thrombus formation in the left atrial appendage and stroke through peripheral embolization. Depending on their origin, large extracellular vesicles (lEVs) can exert pro-coagulant functions. In the present study, we investigated how different types of AF influence the levels of large EV subtypes in three distinct atrial localizations. Blood samples were collected from the right and left atrium and the left atrial appendage of 58 patients. 49% of the patients had permanent AF, 34% had non-permanent AF, and 17% had no history of AF. Flow cytometric analysis of the origin of the lEVs showed that the proportion of platelet-derived lEVs in the left atrial appendage was significantly higher in permanent AF patients compared to non-permanent AF. When we grouped patients according to their current heart rhythm, we also detected significantly higher levels of platelet-derived lEVs in the left atrial appendage (LAA) in patients with atrial fibrillation. In vitro studies revealed, that platelet activation with lipopolysaccharide (LPS) leads to higher levels of miR-222-3p and miR-223-3p in platelet-derived lEVs. Treatment with lEVs from LPS- or thrombin-activated platelets reduces the migration of endothelial cells in vitro. These results suggest that permanent atrial fibrillation is associated with increased levels of platelet-derived lEVs in the LAA, which are potentially involved in LAA thrombus formation.

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