Low-dose heparin for prevention of venous thromboembolism in total hip arthroplasty and surgical repair of hip fractures.

1978 ◽  
Vol 60 (8) ◽  
pp. 1065-1070 ◽  
Author(s):  
P A Moskovitz ◽  
S S Ellenberg ◽  
H L Feffer ◽  
P I Kenmore ◽  
R J Neviaser ◽  
...  
1976 ◽  
Vol 36 (01) ◽  
pp. 157-164 ◽  
Author(s):  
P. M Mannucci ◽  
Luisa E. Citterio ◽  
N Panajotopoulos

SummaryThe effect of subcutaneous low-dose heparin on postoperative deep-vein thrombosis (D. V. T.) (diagnosed by the 125I-labelled fibrinogen test) has been investigated in a trial of 143 patients undergoing the operation of total hip replacement. Two randomized studies were carried out: in one the scanning for D.V.T. was carried out daily for 7 days post operatively and in the other for 15 days. In both, the incidence of D.V.T. was significantly lower in the heparin-treated patients (P<0.005). Bilateral D.V.T. was also prevented (P<0.05), through the extension of D.V.T. to the distal veins of the thigh was not significantly reduced. Heparin treatment was, however, followed by a higher incidence of severe postoperative bleeding (P< 0.02) and wound haematoma formation (P< 0.005), and the postoperative haemoglobin was significantly lower than in the control group (P<0.005). A higher number of transfused blood units was also needed by the heparin treated patients (P<0.001).


2015 ◽  
Vol 39 (5) ◽  
pp. 649-656 ◽  
Author(s):  
Alexander Huppertz ◽  
Alexander Lembcke ◽  
El-hadi Sariali ◽  
Tahir Durmus ◽  
Carsten Schwenke ◽  
...  

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