Incidence of Expression of ER, PR and Her 2 Neu in Infiltrating Ductal Carcinoma Breast: A Cohort Study

Introduction: Prognosis and management of breast cancer are influenced by the classic variables such as histologic type and grade, tumor size, lymph node status, status of hormonal receptors- i.e. estrogen receptor (ER) and progesterone receptor (PR) of the tumor, and, more recently, HER-2/neu (Human Epidermal Growth factor Receptor-2) overexpression. Expression levels of the estrogen, progesterone and HER2/neu receptors which characterize clinically distinct breast tumours have been shown to change during disease progression and in response to systemic therapies. The interrelationship of ER, PR, and HER -2 has come to have a crucial role in the management of breast cancer. Aims & Objectives: To determine the ER, PR and HER2/neu status in breast malignancies. Place and duration of study: The study was conducted at Department of Histopathology, Federal Postgraduate Medical Institute, Shaikh Zayed Hospital Lahore, for the period of Six months. Material & Methods: 30 samples of diagnosed breast cancer were included in study. Formalin fixed paraffin embedded wax block were taken for immunohistochemical staining of ER, PR & HER-2/neu. Results: Out of 30 cases, racially 29 were Punjabi and 1 was Pakhtun. There were 23 mastectomy samples and 7 needle core biopsies. Out of 30 cases, 29 were Infiltrating Ductal Carcinoma. Grade I, II, III 13.3%, 66. 7% and 20% respectively and only one case was of Carcinosarcoma (p<0.01). Overall immunoexpression for ER, PR and HER-2/neu were 33.3% (p<0.01), 56.7% (p<0.05) and 73.3% respectively. Triple positive (TP) cases were 23.3% and triple negative (TN) were 10 %. Regarding ER expression in infiltrating ductal carcinoma, 63.3% were ER negative and 33.3% were ER positive and comparison was statistically highly significant (p<0.01) .PR expression in infiltrating ductal carcinoma showed 56.7% PR positive and 40% PR negative which was statistically significant (p<0.05).There is negative correlation of HER-2/neu positive and ER positive and positive correlation of HER-2/neu positive and PR positive cases. Conclusion: There is inverse correlation of HER-2/neu positive and ER positive and positive correlation of HER-2/neu positive and PR positive cases.

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Infiltrating ductal carcinoma breast with central necrosis closely mimicking ductal carcinoma in situ (comedo type): a case series

Journal of Medical Case Reports ◽

10.1186/1752-1947-1-83 ◽

2007 ◽

Vol 1 (1) ◽

Cited By ~ 8

Author(s):

Shahid Pervez ◽

Hassan Khan

Keyword(s):

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Case Series ◽

Type A ◽

Carcinoma Breast ◽

Central Necrosis ◽

Infiltrating Ductal Carcinoma

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A clinic-pathological prospective study of operable carcinoma breast

International Surgery Journal ◽

10.18203/2349-2902.isj20185044 ◽

2018 ◽

Vol 5 (12) ◽

pp. 4058

Author(s):

Ahila Muthuselvi ◽

Umarani Subramanian ◽

Vinodh Duraisami

Keyword(s):

Adjuvant Chemotherapy ◽

Prospective Study ◽

Hormonal Therapy ◽

Ductal Carcinoma ◽

Tertiary Care ◽

Positive Family History ◽

Disease Patient ◽

Carcinoma Breast ◽

Infiltrating Ductal Carcinoma ◽

Study Population

Background: Cancer breast is the leading cause of site-specific cancer-related death next to cancer cervix for women aged 20-59 years. Early diagnosis and treatment will reduce the morbidity and mortality of the disease and thus prolongs the survival of the patient. The patient usually present in the later stages of disease, due to the lack of awareness. This study aims at studying the various type of clinical and pathological patterns of presentation of operable carcinoma breast in a tertiary care centre.Methods: 50 patients with Carcinoma Breast, admitted in Government Royapettah Hospital were studied. It was a cross-sectional prospective study performed from January 2016 to October 2017.Results: The average age of occurrence of operable carcinoma breast is 48.54 years. One patient had a positive family history. Lump (100%) is the most commonest presentation. 98% of the study population had Infiltrating ductal carcinoma as HPE report. In my study population 56 % of had stage II disease. Patient with Early breast cancer underwent surgery followed by adjuvant chemotherapy, hormonal therapy, and radiotherapy. Patient with stage III disease undergoes neoadjuvant chemotherapy followed by surgery, then adjuvant chemotherapy, hormonal therapy, radiotherapy.Conclusions: The incidence of operable carcinoma breast is more common among middle-aged groups. The commonest presenting complaint is a lump and commonest histopathological type is infiltrating ductal carcinoma. Multimodality modality manage is the optimum treatment adopted. Routine screening mammography and by the health awareness programme carcinoma breast, nowadays, detected at an earlier stage.

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Correlation of DCE-MRI Perfusion Parameters and Molecular Biology of Breast Infiltrating Ductal Carcinoma

Frontiers in Oncology ◽

10.3389/fonc.2021.561735 ◽

2021 ◽

Vol 11 ◽

Author(s):

Li Liu ◽

Nan Mei ◽

Bo Yin ◽

Weijun Peng

Keyword(s):

Triple Negative ◽

Ductal Carcinoma ◽

Growth Factor Receptor ◽

Luminal A ◽

Ki 67 ◽

Dce Mri ◽

Infiltrating Ductal Carcinoma ◽

Breast Infiltrating Ductal Carcinoma ◽

Her 2 ◽

Epidermal Growth

ObjectiveWe aimed to investigate the correlation of the perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with the molecular biological expression of breast infiltrating ductal carcinoma (IDC) in order to guide appropriate therapeutic advice and clinical outcome prediction.Materials and MethodsIn a prospective analysis of 67 patients with breast IDC, preoperative DCE-MRI and routine MRI images were obtained. The double-chamber model (extended Tofts model) was employed to calculate the perfusion parameters. Postoperative pathological immunohistochemistry was examined, including human epidermal growth factor receptor 2 (HER-2), estrogen receptor (ER), progesterone receptor (PR), cell nuclear-associated antigen (Ki-67), cytokeratin 5/6 (CK5/6), and epidermal growth factor receptor (EGFR). Statistical analysis was applied to explore the relationship between the perfusion parameters and the molecular biomarkers of breast cancer.ResultsA total of 67 lesions were included in our study. The mean maximum diameter of lesions was 4.48 ± 1.73 cm. Perfusion parameters had no correlation with tumor diameters (p > 0.05). The volume transfer constant (Ktrans) and the rate constant (kep) had positive correlations with Ki-67 (p < 0.05). The plasma volume ratio (vp) had a statistical difference between CK5/6 positivity and CK5/6 negativity. The maximum rising slope (MAX Slope) was higher in HER-2-enriched tumors than that in luminal A or B tumors (p < 0.05). kep was higher in HER-2-enriched tumors than that in luminal A tumors (p < 0.05). The extravascular extracellular space volume fraction (ve) was higher in triple-negative tumors than that in HER-2-enriched and in luminal A and B tumors (p < 0.05). The time to peak enhancement (TTP) was lower in HER-2-enriched tumors than that in luminal A and B tumors (p < 0.05). Maximum concentration (MAX Conc) was higher in triple-negative tumors than that in luminal B tumors (p < 0.05).ConclusionDCE-MRI perfusion parameters can behave as a noninvasive tool to assess the molecular biological expression and the molecular subtypes of breast IDC. They may aid in predicting breast IDC invasiveness, metastasis, and prognosis.

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