Expression of ER, p53 and HER-2/neu in medullary carcinoma and infiltrating ductal carcinoma with medullary feature

Background: Secretory and medullary carcinomas of the breast are rare subtypes of infiltrating ductal carcinoma. The different histological behavior of medullary and secretory carcinomas is correlated with different imaging features on mammography, ultrasound, and magnetic resonance imaging. Case Report: We report the case of a Caucasian woman in which both subtypes of tumors were diagnosed in an 8-year time interval and evaluate, in antithesis, histopathological and imaging aspects of medullary and secretory carcinoma. Conclusion: To our knowledge, this is the first case reported in literature of secretory carcinoma with a complete imaging tumor evaluation in a patient with a previous contralateral medullary cancer.

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Incidence of Expression of ER, PR and Her 2 Neu in Infiltrating Ductal Carcinoma Breast: A Cohort Study

Indian Journal of Pathology Research and Practice ◽

10.21088/ijprp.2278.148x.8619.5 ◽

2019 ◽

Vol 8 (6) ◽

pp. 745-753

Author(s):

Neha Sharma ◽

◽

Bhupinder Kaur Batth ◽

Mridu Manjari ◽

Arshdeep Kaur ◽

...

Keyword(s):

Cohort Study ◽

Ductal Carcinoma ◽

Carcinoma Breast ◽

Infiltrating Ductal Carcinoma ◽

Her 2

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Correlation of HER-2/neu Status with Estrogen (ER) & Progesterone (PR) Receptor in Breast Malignancies

Proceedings of Shaikh Zayed Medical Complex Lahore - October to December ◽

10.47489/p000s341z7391-9mc ◽

2020 ◽

Vol 34 (1) ◽

pp. 30-38

Author(s):

Asma Rasheed

Keyword(s):

Breast Cancer ◽

Ductal Carcinoma ◽

Inverse Correlation ◽

Lymph Node Status ◽

Medical Institute ◽

Positive Correlation ◽

Infiltrating Ductal Carcinoma ◽

Er Positive ◽

Her 2 ◽

Breast Malignancies

Introduction: Prognosis and management of breast cancer are influenced by the classic variables such as histologic type and grade, tumor size, lymph node status, status of hormonal receptors- i.e. estrogen receptor (ER) and progesterone receptor (PR) of the tumor, and, more recently, HER-2/neu (Human Epidermal Growth factor Receptor-2) overexpression. Expression levels of the estrogen, progesterone and HER2/neu receptors which characterize clinically distinct breast tumours have been shown to change during disease progression and in response to systemic therapies. The interrelationship of ER, PR, and HER -2 has come to have a crucial role in the management of breast cancer. Aims & Objectives: To determine the ER, PR and HER2/neu status in breast malignancies. Place and duration of study: The study was conducted at Department of Histopathology, Federal Postgraduate Medical Institute, Shaikh Zayed Hospital Lahore, for the period of Six months. Material & Methods: 30 samples of diagnosed breast cancer were included in study. Formalin fixed paraffin embedded wax block were taken for immunohistochemical staining of ER, PR & HER-2/neu. Results: Out of 30 cases, racially 29 were Punjabi and 1 was Pakhtun. There were 23 mastectomy samples and 7 needle core biopsies. Out of 30 cases, 29 were Infiltrating Ductal Carcinoma. Grade I, II, III 13.3%, 66. 7% and 20% respectively and only one case was of Carcinosarcoma (p<0.01). Overall immunoexpression for ER, PR and HER-2/neu were 33.3% (p<0.01), 56.7% (p<0.05) and 73.3% respectively. Triple positive (TP) cases were 23.3% and triple negative (TN) were 10 %. Regarding ER expression in infiltrating ductal carcinoma, 63.3% were ER negative and 33.3% were ER positive and comparison was statistically highly significant (p<0.01) .PR expression in infiltrating ductal carcinoma showed 56.7% PR positive and 40% PR negative which was statistically significant (p<0.05).There is negative correlation of HER-2/neu positive and ER positive and positive correlation of HER-2/neu positive and PR positive cases. Conclusion: There is inverse correlation of HER-2/neu positive and ER positive and positive correlation of HER-2/neu positive and PR positive cases.

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Correlation of DCE-MRI Perfusion Parameters and Molecular Biology of Breast Infiltrating Ductal Carcinoma

Frontiers in Oncology ◽

10.3389/fonc.2021.561735 ◽

2021 ◽

Vol 11 ◽

Author(s):

Li Liu ◽

Nan Mei ◽

Bo Yin ◽

Weijun Peng

Keyword(s):

Triple Negative ◽

Ductal Carcinoma ◽

Growth Factor Receptor ◽

Luminal A ◽

Ki 67 ◽

Dce Mri ◽

Infiltrating Ductal Carcinoma ◽

Breast Infiltrating Ductal Carcinoma ◽

Her 2 ◽

Epidermal Growth

ObjectiveWe aimed to investigate the correlation of the perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with the molecular biological expression of breast infiltrating ductal carcinoma (IDC) in order to guide appropriate therapeutic advice and clinical outcome prediction.Materials and MethodsIn a prospective analysis of 67 patients with breast IDC, preoperative DCE-MRI and routine MRI images were obtained. The double-chamber model (extended Tofts model) was employed to calculate the perfusion parameters. Postoperative pathological immunohistochemistry was examined, including human epidermal growth factor receptor 2 (HER-2), estrogen receptor (ER), progesterone receptor (PR), cell nuclear-associated antigen (Ki-67), cytokeratin 5/6 (CK5/6), and epidermal growth factor receptor (EGFR). Statistical analysis was applied to explore the relationship between the perfusion parameters and the molecular biomarkers of breast cancer.ResultsA total of 67 lesions were included in our study. The mean maximum diameter of lesions was 4.48 ± 1.73 cm. Perfusion parameters had no correlation with tumor diameters (p > 0.05). The volume transfer constant (Ktrans) and the rate constant (kep) had positive correlations with Ki-67 (p < 0.05). The plasma volume ratio (vp) had a statistical difference between CK5/6 positivity and CK5/6 negativity. The maximum rising slope (MAX Slope) was higher in HER-2-enriched tumors than that in luminal A or B tumors (p < 0.05). kep was higher in HER-2-enriched tumors than that in luminal A tumors (p < 0.05). The extravascular extracellular space volume fraction (ve) was higher in triple-negative tumors than that in HER-2-enriched and in luminal A and B tumors (p < 0.05). The time to peak enhancement (TTP) was lower in HER-2-enriched tumors than that in luminal A and B tumors (p < 0.05). Maximum concentration (MAX Conc) was higher in triple-negative tumors than that in luminal B tumors (p < 0.05).ConclusionDCE-MRI perfusion parameters can behave as a noninvasive tool to assess the molecular biological expression and the molecular subtypes of breast IDC. They may aid in predicting breast IDC invasiveness, metastasis, and prognosis.

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Differential Amplification and Overexpression of HER-2/neu, p53, MIB1, and Estrogen Receptor/Progesterone Receptor Among Medullary Carcinoma, Atypical Medullary Carcinoma, and High-Grade Invasive Ductal Carcinoma of Breast

Archives of Pathology & Laboratory Medicine ◽

10.5858/2003-127-1458-daaoon ◽

2003 ◽

Vol 127 (11) ◽

pp. 1458-1464

Author(s):

Ruliang Xu ◽

Helen Feiner ◽

Peng Li ◽

Herman Yee ◽

Giorgio Inghirami ◽

...

Keyword(s):

Estrogen Receptor ◽

Progesterone Receptor ◽

Invasive Ductal Carcinoma ◽

Ductal Carcinoma ◽

Medullary Carcinoma ◽

Biological Behavior ◽

High Grade ◽

Formalin Fixed Paraffin Embedded ◽

Her 2 ◽

Lymphocytic Infiltrates

Abstract Context.—Medullary carcinoma (MC) is a special type of breast cancer that has a better prognosis than atypical medullary carcinoma (AMC) and high-grade invasive ductal carcinoma (HGIDC) with prominent lymphocytic infiltrates. What accounts for the different clinical courses of these carcinomas, despite their similar histology, is unknown. To address this issue, we performed a comparative study of amplification and overexpression of HER-2/neu and expression of several other important biochemical markers (p53, MIB1, and estrogen receptor [ER]/progesterone receptor [PR]) in these 3 cancer groups. Objective.—To evaluate HER-2/neu, p53, MIB1, and ER/PR as markers in the differential diagnosis of MC, AMC, and HGIDC. Design.—Nine cases of MC, 13 cases of AMC, and 16 cases of HGIDC with prominent lymphocytic infiltrates were identified according to strict histologic criteria. All tests were performed on formalin-fixed, paraffin-embedded archival tissues. HER-2/neu gene amplification was examined by fluorescence in situ hybridization using PathVysion HER-2 DNA probes. Expression of HER-2/neu, p53, MIB1, and ER/PR was detected by immunohistochemistry. χ2 and Student t tests were applied for statistical analyses. Results.—None of 9 cases of MC examined had either amplification or overexpression of HER-2/neu (0%). In contrast, HER-2/neu amplification was observed in AMC (46%, P < .025) and HGIDC (56%, P < .005). All 3 categories of tumors had similar percentages of expression of p53 (78% of MC, 77% of AMC, and 69% of HGIDC) and MIB1 (89% of MC, 92% of AMC, and 94% of HGIDC). Immunostaining for ER/PR was rarely positive in either MC or AMC, and there were no significant differences of expression of ER/PR between these 2 lesions (P > .05). However, the expression rate of ER/PR (31%/44%) in HGIDC is higher than in both MC (P = .05) and AMC (P = .01). Conclusions.—Medullary carcinoma of breast is distinct from AMC and HGIDC with prominent lymphocytic infiltrates in amplification and overexpression of HER-2/neu. This difference may account for its different clinical and biological behavior, and may potentially aid in diagnosis and management of these groups of patients.

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Carcinoma of breast with medullary features: a case report in 27 year old female

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20195022 ◽

2019 ◽

Vol 7 (11) ◽

pp. 4385

Author(s):

Krutika Patel ◽

Vashudha M. Bhagat ◽

Bhavna Gamit ◽

Deepshikha Dave

Keyword(s):

Ductal Carcinoma ◽

Medullary Carcinoma ◽

Needle Aspiration ◽

Younger Women ◽

Proliferative Lesion ◽

Her 2 ◽

Needle Aspiration Cytology ◽

Invasive Breast Carcinomas ◽

Cytology Report ◽

Histopathological Subtype

Medullary carcinoma of breast is a rare variant of invasive ductal carcinoma of breast and its incidence is less than 5% of invasive breast carcinomas. These tumours tend to occur in younger women, with the average age reported to range from 42 to 52 years. Authors are presenting this case in a 27 years old female having single, large, well circumscribed mass in right breast for 6 months. Fine needle aspiration cytology report was proliferative lesion with atypia Histopathology report was given as carcinoma with medullary features. Immunohistochemistry showed Estrogen Receptor (ER), Progesterone Receptor (PR) and Her-2 neu negative. Authors are presenting this case of Medullary carcinoma of breast for being a specific histopathological subtype.

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