Effect of Intravitreal Ranibizumab in CSCR with Ink Blot Type of Leakage and NSD More Than 3 Months Duration

2016 ◽  
Vol 2 (1) ◽  
pp. 7-12
Author(s):  
Abhinav Singh ◽  
◽  
Sagarika Patyal ◽  
Gaurav Kapoor ◽  
Sonya Puri ◽  
...  
2019 ◽  
Author(s):  
Jiri Lukavsky ◽  
Vojtěch Klinger

In boundary extension (BE), people confidently remember seeing a surrounding region of a scene that was not visible in the studied view. However, the content near image boundaries might be uninteresting, serving only as a background for a central figure.In our experiments, we presented participants with 24 photographs with a defect (cut-out hole or black ink blot). Participants were instructed to memorize the photograph and then either reproduce the size of the hole/blot (BE task) or identify a change (distractor task). In Exp. 1, we showed participants printed photographs (18×13 cm) with cut-out holes. Participants systematically drew smaller holes (87.5% diameter, N=32). When we replaced the holes with black ink blots (Exp. 2), the bias was still present (91.4%, N=30). The computer-based version with size-adjustment of black blots (Exp. 3) yielded similar effects (92.8%, N=30), which disappeared (Exp. 4, 100.7%, N=30) if the probe blot sizes were randomized.We argue that BE occurs in the internal parts of photographs. We explored the effect in different media (paper/screen) and using different response tasks (free recall/adjustment). People show uncertainty in the adjustment tasks and reproduce remembered holes/blots as smaller (consistent with BE) if they are presented with the occluded content in the response phase.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoshimi Sugiura ◽  
Fumiki Okamoto ◽  
Tomoya Murakami ◽  
Shohei Morikawa ◽  
Takahiro Hiraoka ◽  
...  

AbstractTo evaluate the effects of intravitreal ranibizumab injection (IVR) on metamorphopsia in patients with branch retinal vein occlusion (BRVO), and to assess the relationship between metamorphopsia and inner retinal microstructure and other factors. Thirty-three treatment-naïve eyes of 33 patients with macular edema caused by BRVO with at least 12 months of follow-up were included. The degree of metamorphopsia was quantified using the M-CHARTS. Retinal microstructure was assessed with spectral-domain optical coherence tomography. Disorganization of the retinal inner layers (DRIL) at the first month after resolution of the macular edema (early DRIL) and at 12 months after treatment (after DRIL) was studied. Central retinal thickness (CRT), and status of the external limiting membrane as well as ellipsoid zone were also evaluated. IVR treatment significantly improved best-corrected visual acuity (BCVA) and CRT, but the mean metamorphopsia score did not improve even after 12 months. Post-treatment metamorphopsia scores showed a significant correlation with pre-treatment metamorphopsia scores (P < 0.005), the extent of early DRIL (P < 0.05) and after DRIL (P < 0.05), and the number of injections (P < 0.05). Multivariate analysis revealed that the post-treatment mean metamorphopsia score was significantly correlated with the pre-treatment mean metamorphopsia score (P < 0.05). IVR treatment significantly improved BCVA and CRT, but not metamorphopsia. Post-treatment metamorphopsia scores were significantly associated with pre-treatment metamorphopsia scores, the extent of DRIL, and the number of injections. Prognostic factor of metamorphopsia was the degree of pre-treatment metamorphopsia.


2016 ◽  
Vol 236 (2) ◽  
pp. 67-73 ◽  
Author(s):  
Yoshito Koyanagi ◽  
Shigeo Yoshida ◽  
Yoshiyuki Kobayashi ◽  
Yuki Kubo ◽  
Muneo Yamaguchi ◽  
...  

Purpose: To compare the effectiveness of intravitreal ranibizumab (IVR) for diabetic macular edema (DME) between eyes with and without previous vitrectomy. Procedures: We prospectively assessed the best-corrected visual acuity (BCVA) and central macular thickness (CMT) after IVR for 6 months. Results: There were no significant differences in the baseline BCVA and CMT between both groups. In the nonvitrectomized group (n = 15), the mean changes of BCVA and CMT from baseline to month 6 were significant (p < 0.01). In the vitrectomized group (n = 10), the improvement appeared to be slower, and the mean BCVA improvement was not significant (p = 0.5), although the mean CMT decrease was significant (p < 0.05). There were no significant differences in the mean changes of BCVA and CMT between both groups at 6 months. Conclusions: The difference in the effectiveness of IVR between both groups was not significant. IVR can be a treatment option even for vitrectomized DME eyes.


2012 ◽  
Vol 3 (1) ◽  
pp. 136-141 ◽  
Author(s):  
Ágata Mota ◽  
Ângela Carneiro ◽  
Jorge Breda ◽  
Vitor Rosas ◽  
Augusto Magalhães ◽  
...  

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