scholarly journals Synthesis and Characterization of Some New Benzodiazepinium Salt Derivatives under microwave Irradiation

2015 ◽  
Vol 12 (4) ◽  
pp. 753-760
Author(s):  
Baghdad Science Journal
Keyword(s):  
Reaction Mechanism ◽  
Microwave Irradiation ◽  
Benzoic Acid ◽  
Nmr Spectra ◽  
Synthesis And Characterization ◽  
Benzoic Acid Derivatives ◽  
Unexpected Reaction ◽  
Ft Ir ◽  
New Compounds

An attempt to synthesize the benzoimidazol derivatives from the reaction of o-phenylenediamine and benzoic acid derivatives in the presence of ethanol and various ketones under microwave irradiation, 1 , 5 - benzodiazepinum salt derivatives were obtained instead of them. Unexpected reaction was happened for synthesis a new series of benzodiazepinium salt derivatives in a selective yield . The reaction mechanism was also discussed. The new compounds were purified and identified their structures were elucidated using various physical techniques like; FT- IR spectra, micro elemental analysis (C.H.N) and 1H NMR spectra.

scholarly journals Synthesis and Characterization of some New 1,3,4-Oxadiazole derivatives based on 4-amino benzoic acid

2016 ◽  
Vol 13 (4) ◽  
pp. 762-769
Author(s):  
Baghdad Science Journal
Keyword(s):  
Schiff Base ◽  
Benzoic Acid ◽  
Spectral Data ◽  
1H Nmr ◽  
Synthesis And Characterization ◽  
Oxadiazole Derivatives ◽  
Ft Ir ◽  
Amino Benzoic Acid

Various of 2,5- disubstituted 1,3,4-oxadiazole (Schiff base, ?- lactam and azo) were synthesized from 2,5-di (4,4?-amino-1,3,4-oxadiazole which usequently synth-esized from mixture of 4- amino benzoic acid and hydrazine arch of polyphosphorus acid. The synthesized compounds were cherecterized by using some spectral data (UV, FT-IR , and 1H-NMR)

Synthesis and Characterization of New Dibenzo[b, e]Thiepine Derivatives. I

2009 ◽  
Vol 59 (12) ◽  
Author(s):  
Camelia Elena Stecoza ◽  
Miron Teodor Caproiu ◽  
Constantin Draghici ◽  
Corina Ilie ◽  
Ileana Cornelia Chirita
Keyword(s):  
Hydrogen Peroxide ◽  
Spectral Analysis ◽  
Benzoic Acid ◽  
Potassium Salt ◽  
Polyphosphoric Acid ◽  
Chemical Characterization ◽  
Synthesis And Characterization ◽  
Acid Chlorides ◽  
New Compounds

The aim of the present paper was the synthesis and chemical characterization of some original compounds with dibenzo[b,e]thiepine structure. The synthesis of the new compounds was performed in several stages. Thus, by reaction of phtalide with thiophenol potassium salt, we obtained the 2-phenylthiomethyl-benzoic acid. The acid was cyclized with polyphosphoric acid to the desired 6,11-dihydrodibenzo[b,e]thiepin-11(6H)-one, converted afterwards to the corresponding oxime and subsequently to the O-acyloximino-dibenzo[b,e]thiepins by acylation with various substituted benzoic acid chlorides. The oxidation of O-acyloximino-dibenzo[b,e]thiepins with hydrogen peroxide afforded the corresponding sulfones. The new compounds, four O-acyl-oximino-dibenzo[b,e]thiepins, and four O-acyl-oximino-dibenzo[b,e]thiepin-5,5-dioxides, have been characterized by their physical constants (melting point, solubility) and their structures and purity were confirmed by elemental analysis, and spectral analysis (IR, 1H-NMR, 13C-NMR).

scholarly journals Synthesis and Characterization of Five, Sevene Heterocyclic Membered Rings

2013 ◽  
Vol 10 (3) ◽  
pp. 803-817
Author(s):  
Baghdad Science Journal
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
13C Nmr ◽  
Starting Material ◽  
Synthesis And Characterization ◽  
Melting Points ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
New Compounds

New compounds containing heterocyclic units have been synthesized. These compounds include 2-amino 5- phenyl-1,3,4-thiadiazole (1) as starting material to prepare the Schiff bases 2N[3-nitrobenzylidene -2 hydroxy benzylidene and 4-N,N-dimethyl aminobenzylidene] -5-phenyl-1,3,4-thiadiazole (2abc) , 2N[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl] 3-]2-amino-5-phenyl-1,3,4-thiadiazole]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dione] (3abc), 2N[3-nitrophenyl,2-hydroxyphenyl,4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-4,7-dione[(4abc), 2-N-[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2yl]-1,2,3-trihydro-benzo-[1,2-e][1,3] diazepine-4,7-dione (5abc) ,2N[2-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)]-4-oxo-1,3-thiazolidine-3-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (6abc), 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-tetrazolo-1-yl]-2-amino-5-phenyl-1,3,4-thiadiazole (7abc) , 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dithione (8abc) , 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine -4,7-dithione -5-ene (9abc) and 2-N-[5-(3-nitrophenyl,2-hydroxyphenyl or 4-N,N-dimethylaminophenyl)-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl] -1,2,3-trihydro-benzo-[1,2-e][1,3] diazepine -4,7-dithione - (10abc) . the structures of these compounds were characterized by FT-IR, 1H,13C-NMR,Uv/vis spectroscopy and the melting points were determined besides the evaluation of its biological activity.

scholarly journals Synthesis and Characterization of Some New Azo Dyes Derivatives Via Chalcone and Study Some of Their Biological Activity

2016 ◽  
Vol 13 (1) ◽  
pp. 122-132
Author(s):  
Baghdad Science Journal
Keyword(s):  
Biological Activity ◽  
Azo Dyes ◽  
Coupling Reaction ◽  
Basic Medium ◽  
Synthesis And Characterization ◽  
Diazonium Salts ◽  
Amino Group ◽  
Ft Ir ◽  
New Compounds

This work includes synthesis of new six membered heterocyclic rings with effective amino group using the reaction of benzylideneacetophenone (chalcone) (1) with thiourea or urea in alcoholic basic medium to form: 1,3-thiazen-2-amine (2), and 1,3-oxazin-2-amine (8) respectively. The diazotization reaction was carried out with sodium nitrite in presence of hydrochloric acid to form diazonium salts which suffered coupling reaction with naphthols and phenols in the presence of sodium hydroxide to form colored azo dyes (4-7, and 10-13). o-methylation reaction of compounds (7) and (10) yielded : 1,3-thiazin -2-yl-diazenyl (14), and 1,3-oxazin-2-yl-diazenyl (15) respectively.The new compounds were characterized using various physical techniques like: UV-Vis., FT-IR, and 1HNMR spectra. Some new compounds were tested against bacteria.

scholarly journals Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique

2018 ◽  
Vol 29 (2) ◽  
pp. 101
Author(s):  
Faiq H. Saaid ◽  
Shatha J. Dawood ◽  
Bushra H. Marbeen
Keyword(s):  
Infrared Spectra ◽  
Chloroacetic Acid ◽  
Synthesis And Characterization ◽  
Dilution Method ◽  
Ultrasonic Technique ◽  
Serial Dilution Method ◽  
Oxadiazole Derivatives ◽  
Ft Ir ◽  
New Compounds

In the present study, a new of 1,3,4-oxadizole derivatives(4a1,4a2,4b1,4b2) were synthesized using an ultrasonic technique. Benzohydrazine and its substituted (2a, 2b) were obtained from the reaction of hydrazin with benzoylchloride and its substituted (1a, 1b). Compounds (2a, 2b) react with chloroacetic acid to form compounds (3a,3b) which react with p-phenylene diamine and hydrazine in presence of DMSO as a solvent to obtain new compounds (4a1,4a2, 4b1,4b2) by ultrasonic technique. The structures of the synthesized compounds were elucidated by spectral data: infrared spectra (FT-IR) and 1HNMR and CHN analysis. The synthesis compounds (4b1, 4b2, 4a1, and 4a2) were evaluated for antibacterial (Staphylococcus1 aureus) by the serial dilution method

scholarly journals Synthesis and Characterization of Some New Nucleoside Analogues from Substituted Benzimidazole via 1,3-Dipolar cycloaddition

2016 ◽  
Vol 13 (2) ◽  
pp. 298-306
Author(s):  
Baghdad Science Journal
Keyword(s):  
Benzoic Acid ◽  
Benzimidazole Derivative ◽  
Cycloaddition Reaction ◽  
Nucleoside Analogues ◽  
Dipolar Cycloaddition ◽  
Synthesis And Characterization ◽  
Propargyl Bromide ◽  
Sugar Moiety ◽  
Ft Ir

This paper includes the synthesis of some new nucleoside analogues starting with 2-substituted benzimidazole derivative (7-9), that synthesized by condensation of O-phenylenediamine with p-chloro benzaldehyde and two substituted benzoic acid , which on nucleophilic substitution with propargyl bromide gave a new N-substituted compounds (10-12). D-Fructose and D-galactose were chosen as a sugar moiety which were protected, brominated and azotated to give azido sugars (5) and (6), then they were subjected to 1,3-dipolar cycloaddition reaction with N-substuted compounds afforded bloked nucleoside analoges (13-16), which after hydrolysis gave our target the free nucleoside analogues (17-20). All prepared compounds were identified by FT-IR and some of them with 1H-NMR and 13C-NMR.

scholarly journals Synthesis and Characterization of New 2-Quinolone Sulfonamide Derivatives

2016 ◽  
Vol 13 (4) ◽  
pp. 806-818
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nitric Acid ◽  
13C Nmr ◽  
Ethyl Acetoacetate ◽  
Nmr Spectra ◽  
Synthesis And Characterization ◽  
13C Nmr Spectra ◽  
Substituted Phenols ◽  
Ft Ir ◽  
Quinolone Derivatives

A series of new 2-quinolone derivatives linked to benzene sulphonyl moieties were performed by many steps: the first step involved preparation of different coumarins (A1,A2) by condensation of different substituted phenols with ethyl acetoacetate. The compound A1 was treated with nitric acid to afford two isomers of nitrocoumarin derivatives (A3) and (A4). The prepared compounds (A2, A3) were treated with hydrazine hydrate to synthesize different 2-quinolone compounds (A5,A6) while the coumarin treated with different amines gave compounds (A7,A8). Then the synthesized 2-quinolone compounds (A5-A8) treated with benzene sulphonyl chloride to afford new sulfonamide derivatives (A9-A12). The synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra and by measurement some of their physical properties.

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