scholarly journals Assessment of Pro Hepcidin and Related with Iron Profile on Hemodialysis Men Patients

2016 ◽  
Vol 13 (1) ◽  
pp. 74-81
Author(s):  
Baghdad Science Journal
Keyword(s):  
Renal Failure ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Extracellular Fluid ◽  
Total Iron ◽  
Iron Store ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Binding Capacity ◽  
Iron Profile

Patients with renal failure in the final stages undergo the treatment by hemodialysis. Hemodialysis is used to reinstate the intracellular and extracellular fluid environment, by propagation of molecules in solution through a semipermeable membrane along an electrochemical concentration gradient. Blood catching in the dialysis machine and the recurrent phlebotomy may lead to losing about 1-3 g of iron per year. Prohepcidin hormone is an acute phase protein (type II) that plays a major role in the systemic iron irregularities as it is a mediator of anemia in inflammation and regulator of iron metabolism. This study aims to evaluate the effect of hemodialysis on iron hemostasis and its relationship with prohepcidin as an inflammatory marker. This study includes forty four adult male patients with end-stage renal failure (in pre and post –treated) by means of chronic hemodialysis-HD with mean age (53.27 ± 13.76 years). The following biochemical investigations have been studied: Prohepcidin, Iron, Ferritin, Transferrin, Total Iron-Binding Capacity (TIBC), The Unsaturated Total Iron Binding Capacity (UIBC), and transferrin saturation (TAST).Decrement of Prohepcidin level on hemodialysis patients in post dialysis with non-significantly compared to pre dialysis, while iron and ferritin was increment in post treated than pre- treated with non-significantly.Hemodialysis affects Prohepcidin levels as it was long duration and Glomerular Filtration rate GFR (cock croft equation) and prohepcidin level affect the iron profile related with the iron store depletion.

Serum iron and total iron-binding capacity compared with serum ferritin in assessment of iron deficiency.

1981 ◽  
Vol 27 (2) ◽  
pp. 276-279 ◽  
Author(s):  
F Peter ◽  
S Wang
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Deficient ◽  
Iron Binding Capacity

Abstract Ferritin values for 250 selected sera were compared with values for iron, total iron-binding capacity (TIBC), and transferrin saturation, to assess the potential of the ferritin assay for the detection of latent iron deficiency. The specimens were grouped (50 in each group) according to their values for iron and TIBC. In Group 1 (low iron, high TIBC) the saturation and ferritin values both indicated iron deficiency in all but one. In the 100 specimens of Groups 2 (normal iron, high TIBC) and 4 (normal iron, high normal TIBC), the saturation values revealed 16 iron-deficient cases, the ferritin test 55. For Groups 3 (low iron, normal TIBC) and 5 (low iron, low TIBC), the ferritin test revealed fewer cases of iron deficiency than did the saturation values (37 cases vs 51 cases, in the 100 specimens). Evidently the ferritin test detects iron deficiency in many cases for whom the serum iron and TIBC tests are not positively indicative. The correlation of serum ferritin with iron, TIBC, and transferrin saturation in the five groups was good only in the case of specimens for which the TIBC was normal; if it was abnormal the correlation was very poor.

scholarly journals Gambaran status besi pada pasien penyakit ginjal kronik stadium 5 dengan anemia yang menjalani hemodialisis reguler

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Bryan J. Silaban ◽  
Cerelia Sugeng ◽  
Bradley J. Waleleng
Keyword(s):  
End Stage Renal Disease ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Stage Renal Disease ◽  
End Stage ◽  
Iron Binding Capacity

Abstract: Chronic kidney disease (CKD) is a pathological condition with a variety of etiology, resulting in progressively decreased renal function which is often ended with kidney failure. Chronic kidney disease has a global prevalence of 800 per million of population and the incidence of end-stage renal disease ranges from 150 to 200 per million of population. Complications often occur at the end-stage renal disease inter alia anemia with a rate of 80-90%. This study was aimed to obtain the profile of stage-5 CKD patients with anemia and regular hemodialysis was performed on them. This was a descriptive-retrospective study using data of medical records at Prof. Dr. R. D. Kandou General Hospital from January 2015 to October 2016. There were six observed variables as follows: age, gender, serum iron (SI), total iron binding capacity (TIBC), transferrin saturation, and ferritin. The results showed that of the 48 CKD patients with anemia, there were 24 males and 24 females. The majority were aged 60-69 years (33%) and had normal SI level in 30 patients (67%); decreased TIBC in 35 patients (75%); normal transferrin saturation in 26 patients (54%); and increased ferritin level in 38 patients (81%). Conclusion: Majority of the patients were 60-69 years old and had normal level of SI, decreased TIBC, normal transferrin saturation, and increased levels of ferritin. There was no difference in case number of both sexes.Keywords: serum iron, total iron binding capacity, transferrin saturation, ferritin Abstrak: Penyakit Ginjal Kronik (PGK) adalah suatu keadaan patologis dengan etiologi yang beragam, terjadi penurunan fungsi ginjal secara progresif, dan biasanya berakhir dengan gagal ginjal. Penyakit ginjal kronik merupakan salah satu masalah kesehatan di dunia dengan prevalensi 800 per juta populasi dan insidensi end-stage renal disease (ESRD) 150-200 per juta populasi di dunia. Komplikasi sering terjadi pada PGK stadium akhir antara lain anemia dengan persentase mencapai 80-90%. Penelitian ini bertujuan untuk mendapatkan profil pasien PGK stadium 5 dengan anemia dan menjalani hemodialisis reglular. Jenis penelitian ialah deskriptif-retrospektif menggunakan data sekunder dari catatan rekam medik periode Januari 2015 – Oktober 2016 di RSUP Prof. Dr. R. D. Kandou Manado dengan enam variabel penelitian, yaitu usia, jenis kelamin, serum iron (SI), total iron binding capacity (TIBC), saturasi transferin, dan feritin. Dari 48 data rekam medik pasien yang memenuhi kriteria inklusi ditemukan bahwa mayoritas pasien berumur 60-69 tahun (33%), laki-laki maupun perempuan berjumlah sama, mayoritas pasien memiliki kadar SI normal berjumlah 30 pasien (67%), kadar TIBC menurun berjumlah 35 pasien (75%), saturasi transferin normal berjumlah 26 pasien (54%), dan kadar feritin meningkat berjumlah 38 pasien (81%). Simpulan: Mayoritas pasien PGK stadium 5 yang menjalani hemodialisis reguler berusia 60-69 tahun, laki-laki dan perempuan berjumlah sama, serta memiliki kadar SI normal, penurunan TIBC, saturasi transferin normal, dan peningkatan kadar feritin. Kata kunci: serum iron, total iron binding capacity, saturasi transferin, feritin

scholarly journals Profil Zat Besi Ibu Hamil di Daerah Endemis Malaria

2013 ◽  
Vol 8 (5) ◽  
pp. 195
Author(s):  
Rostika Flora ◽  
Bina Melvia ◽  
Sigit Purwanto
Keyword(s):  
Serum Level ◽  
Pregnant Women ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Endemic Malaria ◽  
History Of ◽  
Iron Binding Capacity ◽  
Iron Profile

Pada saat kehamilan, terjadi peningkatan kebutuhan zat besi (Fe) yang diperlukan untuk meningkatkan jumlah sel darah merah ibu dan membentuk sel darah merah janin dan plasenta. Apabila kebutuhan zat besi ini tidak terpenuhi, akan terjadi anemia defisiensi besi. Ibu hamil yang tinggal di daerah endemis malaria rentan terinfeksi malaria, yang berdampak terhadap anemia pada kehamilan. Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang yang bertujuan untuk mengetahui gambaran profil zat besi pada ibu hamil yang berada di daerah endemis malaria vivax kota Bengkulu. Pemeriksaan mikroskopis malaria dan pengambilan sampel darah dilakukan untuk pemeriksaan profil zat besi terhadap 55 orang ibu hamil trimester II dan III yang mempunyai riwayat malaria di 5 wilayah kerja puskesmas. Data yang diperoleh kemudian dilakukan analisis univariat. Pada ibu hamil yang tidak terinfeksi malaria tetapi mempunyai riwayat malaria, 90,5% mengalami anemia, 41,5% mengalami penurunan kadar Total Iron Binding Capacity (TIBC), dan 17% mengalami penurunan kadar Fe serum. Ibu hamil yang terinfeksi malaria vivax selain terjadi penurunan kadar hemoglobin juga disertai dengan penurunan kadar Fe serum dan kadar TIBC. Pada ibu hamil yang menderita malaria falsiparum, terjadi penurunan kadar hemoglobin (Hb) dan kadar TIBC tetapi tidak disertai dengan penurunan kadar Fe serum. Ibu hamil yang terinfeksi malaria maupun yang mempunyai riwayat terinfeksi malaria mengalami anemia pada kehamilan.During pregnancy, the need of iron increase significantly. Iron is needed for increasing the amount of mother’s red blood cell and form the red blood cell of fetus and placenta. If this iron needs is not fulfilled, it could cause iron deficiency anemia. Pregnant women who live in endemic malaria will be vulnerable to be infected malaria, and will cause anemia in pregnancy. This research was aimed to know iron profile in pregnant women that live in endemic malaria area. Malaria microscopic examination and blood sampling for examination of iron profile in 55 pregnant women trimester II and III who have a history of malaria in 5 working area health centers. The data obtained was then performed univariate analysis. The results showed pregnant women who have malaria history, 90.5% are suffering anemia, decreasing of Total Iron Binding Capacity (TIBC) level (41.5%) and 17% Fe serum level (17%). Pregnant women who are infected vivax malaria not only experiencing decrease of hemoglobin level but also experiencing decrease of Fe serum level and TIBC level, while pregnant woman who suffers from falciparum malaria haemoglobin (Hb) level and TIBC are decreasing but not in serum Fe levels. Pregnant women with history of malaria infection will suffer from anemia during pregnancy.

Effects of resistance training on serum iron, total iron-binding capacity and transferrin saturation in police working dogs

2019 ◽  
Vol 15 (4) ◽  
pp. 253-258 ◽  
Author(s):  
B.S.N. Ramos ◽  
V.S. Moraes ◽  
R.M. Pinheiro ◽  
V.R.C. Souza ◽  
J.C. Alves ◽  
...  
Keyword(s):  
Resistance Training ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
German Shepherd ◽  
Working Dogs ◽  
Iron Binding Capacity

The aim of this research was to evaluate the effects of a resistance training protocol on iron metabolism of police working dogs. Understanding of how physical exercise influences biochemical parameters is essential for a proper interpretation of exams and adjustments of nutritional and conditioning programs. Nine dogs, being four Belgian Malinois and five German Shepherd, 18.56±0.53 months old, were evaluated before (M1) and six weeks after (M2) a training program using a treadmill. Training sessions were performed twice/week including a 20-min of treadmill activity on a speed compatible with 60-80% of HRpeak on weeks 1 and 2; same exercise of weeks 1 and 2 with a 5% grade added between 7.5 and 12.5 min on weeks 3 and 4; and, same protocol of weeks 3 and 4 with three short bursts of strenuous exercise 60 min after the end of the treadmill exercise on weeks 5 and 6. On both moments (M1 and M2), animals were examined and blood samples were obtained before (T0) and after (T1) an incremental effort test and at 30 min (T2) and 120 min (T3) of recovery. Serum iron (Fe), total iron-binding capacity (TIBC) and transferrin saturation (TS) were determined. All variables were analysed using Tukey test, with P<0.05. Iron parameters were not modified by the current exercise protocol for training police working dogs.

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