Spatial cluster analysis of Plasmodium vivax and P. malariae exposure using serological data among Haitian school children sampled between 2014 and 2016

Background Estimation of malaria prevalence in very low transmission settings is difficult by even the most advanced diagnostic tests. Antibodies against malaria antigens provide an indicator of active or past exposure to these parasites. The prominent malaria species within Haiti is Plasmodium falciparum, but P. vivax and P. malariae infections are also known to be endemic. Methodology/Principal findings From 2014–2016, 28,681 Haitian children were enrolled in school-based serosurveys and were asked to provide a blood sample for detection of antibodies against multiple infectious diseases. IgG against the P. falciparum, P. vivax, and P. malariae merozoite surface protein 19kD subunit (MSP119) antigens was detected by a multiplex bead assay (MBA). A subset of samples was also tested for Plasmodium DNA by PCR assays, and for Plasmodium antigens by a multiplex antigen detection assay. Geospatial clustering of high seroprevalence areas for P. vivax and P. malariae antigens was assessed by both Ripley’s K-function and Kulldorff’s spatial scan statistic. Of 21,719 children enrolled in 680 schools in Haiti who provided samples to assay for IgG against PmMSP119, 278 (1.27%) were seropositive. Of 24,559 children enrolled in 788 schools providing samples for PvMSP119 serology, 113 (0.46%) were seropositive. Two significant clusters of seropositivity were identified throughout the country for P. malariae exposure, and two identified for P. vivax. No samples were found to be positive for Plasmodium DNA or antigens. Conclusions/Significance From school-based surveys conducted from 2014 to 2016, very few Haitian children had evidence of exposure to P. vivax or P. malariae, with no children testing positive for active infection. Spatial scan statistics identified non-overlapping areas of the country with higher seroprevalence for these two malarias. Serological data provides useful information of exposure to very low endemic malaria species in a population that is unlikely to present to clinics with symptomatic infections.

mini projek PPM penyakit malaria

Malaria masih merupakan masalah kesehatan di negara tropis, dengan perkiraan sekitar 40% penduduk dunia masih mengidap malaria. Penyakit malaria juga masih merupakan masalah kesehatan global, karena menyebabkan kematian dan mengakibatkan dampak sosial ekonomi besar terutama penduduk miskin yang bermukim di negara-negara sedang berkembang endemic malaria.

pamplet ppm penyakit malaria

Malaria masih merupakan masalah kesehatan di negara tropis, dengan perkiraan sekitar 40% penduduk dunia masih mengidap malaria. Penyakit malaria juga masih merupakan masalah kesehatan global, karena menyebabkan kematian dan mengakibatkan dampak sosial ekonomi besar terutama penduduk miskin yang bermukim di negara-negara sedang berkembang endemic malaria.

Niger's humanitarian situation looks set to worsen

Significance On Niger’s side of the border, by September 27 there were over 5,000 cases across six of the country’s eight regions -- numbers exceeding those of the country’s last major outbreak in 2018. The outbreak compounds Niger’s existing health, natural disaster, food security and displacement challenges, all in the world’s poorest country. Impacts The public health crises and other strains add to the worsening insecurity and COVID-19 burdens. Endemic malaria places the rudimentary health system under permanent strain, leaving it ill-equipped to deal with disease outbreaks. Rising levels of displacement could slow down efforts to stem the cholera outbreak.

Gender Influence on Asymptomatic Malaria Diagnosis

The characterisation and identification of malaria reservoirs are major challenges for the efficacy of control and elimination programs. Malaria asymptomatic infections are highly prevalent in different malaria settings worldwide and constitute a great obstacle for disease control and elimination. The monitoring of asymptomatic malaria infection requires active case detection in many cases challenging the limit of diagnostic technology detection. We evaluated diagnostic methods and analyzed the gender dimension implication for asymptomatic malaria diagnosis on a high-endemic malaria region during the dry-season.

UP4DREAM CAPACITY BUILDING PROJECT: UAS BASED MAPPING IN DEVELOPING COUNTRIES

UP4DREAM (UAV Photogrammetry for Developing Resilience and Educational Activities in Malawi) is a cooperative project cofounded by ISPRS between the Polytechnic University of Turin and the United Nations Children Fund (UNICEF) Malawi, with the support of two local Universities (Lilongwe University of Agriculture and Natural Resources, and Mzuzu University), and Agisoft LLC (for the use of their photogrammetry and computer vision software suite). Malawi is a flood-prone landlocked country constantly facing natural and health challenges, which prevent the country's sustainable socio-economic development. Frequent naturals shocks leave vulnerable communities food insecure. Moreover, Malawi suffers from high rates of HIV, as well as it has endemic malaria. The UP4DREAM project focuses on one of the drone project's critical priorities in Malawi (Imagery). It aims to start a capacity-building initiative in line with other mapping missions in developing countries, focusing on the realization and management of large-scale cartography (using GIS - Geographic Information Systems) and on the generation of 3D products based on the UAV-acquired data. The principal aim of UP4DREAM is to ensure that local institutions, universities, researchers, service companies, and manufacturers operating in the humanitarian drone corridor, established by UNICEF in 2017, will have the proper knowledge and understanding of the photogrammetry and spatial information best practices, to perform large-scale aerial data acquisition, processing, share and manage in the most efficient, cost-effective and scientifically rigorous way.

Malaria in Europe: A Historical Perspective

Endemic malaria, which claimed 229 million new cases and 409,000 deaths in 2019 mainly in Africa, was eradicated from Europe by the mid-20th century. Historical descriptions of intermittent tertian and quartan fever reported in texts of Hippocrates in Greece and Celsus in Italy suggest malaria. A few paleomicrobiology investigations have confirmed the presence of malarial parasite Plasmodium falciparum in 1st, 2nd, and 5th century infected individuals in diverse regions of Italy, and Plasmodium sp. later in Bavaria. The causative Plasmodium pathogens, discovered in the 19th century in Algeria, were controversially used as therapeutic agents in the European pharmacopeia more than two centuries after effective quinine-based treatments had been introduced in Europe. How Europe managed to eradicate malaria and what the history of malaria was in Europe are of medical interest, and this review traces research pathways for a renewed understanding of malaria eradication in Europe through combined historical and paleomicrobiological investigations.

The Story of a Ship Journey, Malaria, and the HBB Gene IVS-II-745 Mutation: Circassian İmmigration to Cyprus

Background During 19th century, the Circassians were secluded from their lands and forced to migrate to Ottoman Empire properties. Approximately 2,346 Circassians were exiled from Istanbul to Cyprus Island. During the deportation journey, many of Circassian were passed away in consequence of malaria and unknown reasons. Overall, 1,351 survivor Circassians managed to reach the island, however, many of them had faced with endemic malaria again in Cyprus. An autosomal recessive hematological disorder thalassemia was the second endemic health condition after malaria, whereas thalassemia carriers show resistance to malaria infections. Materials and Methods A large Cypriot family with 57 members whose grandparents were supposed to be in that ship journey has been investigated in this study. Polymerase chain reaction (PCR)–amplification refractory mutation system (ARMS) analysis technique was used for genotyping the HHB gene. Results The human β-globin (HBB) gene c.316–106C > G (IVS-II-745) (II-745) heterozygous variation have been detected. Conclusion Overall, this study is a very good example for a typical natural selection. In this case, one single gene point mutation did not limit survival in the society; natively, it increased their survival changes to form new colonization and the inheritance of the mutation to the next generations.

HIV-1 Infection Is Associated With Increased Prevalence and Abundance of Plasmodium falciparum Gametocyte-Specific Transcripts in Asymptomatic Adults in Western Kenya

As morbidity and mortality due to malaria continue to decline, the identification of individuals with a high likelihood of transmitting malaria is needed to further reduce the prevalence of malaria. In areas of holoendemic malaria transmission, asymptomatically infected adults may be infected with transmissible gametocytes. The impact of HIV-1 on gametocyte carriage is unknown, but co-infection may lead to an increase in gametocytemia. In this study, a panel of qPCR assays was used to quantify gametocyte stage-specific transcripts present in dried blood spots obtained from asymptomatic adults seeking voluntary HIV testing in Kombewa, Kenya. A total of 1,116 Plasmodium-specific 18S-positive samples were tested and 20.5% of these individuals had detectable gametocyte-specific transcripts. Individuals also infected with HIV-1 were 1.82 times more likely to be gametocyte positive (P<0.0001) and had significantly higher gametocyte copy numbers when compared to HIV-negative individuals. Additionally, HIV-1 positivity was associated with higher gametocyte prevalence in men and increased gametocyte carriage with age. Overall, these data suggest that HIV-positive individuals may have an increased risk of transmitting malaria parasites in regions with endemic malaria transmission and therefore should be at a higher priority for treatment with gametocidal antimalarial drugs.