scholarly journals Interleukin-1 Receptor Antagonist (IL-1RN) Gene Variable Number Tandem Repeats (VNTR) Polymorphism Association in men Infertility in Erbil City /Kurdistan Iraq

2021 ◽  
Vol 18 (3) ◽  
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Variable Number ◽  
Vntr Polymorphism ◽  
Interleukin 1 Receptor Antagonist ◽  
Variable Number Tandem Repeats

scholarly journals Interleukin-1 Receptor Antagonist and Interleukin-4 Genes Variable Number Tandem Repeats Are Associated with Adiposity in Malaysian Subjects

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Yung-Yean Kok ◽  
Hing-Huat Ong ◽  
Yee-How Say
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Variable Number ◽  
Interleukin 4 ◽  
Ethnic Chinese ◽  
Interleukin 1 Receptor Antagonist ◽  
Total Body ◽  
Variable Number Tandem Repeats ◽  
Intron 2

Interleukin-1 receptor antagonist (IL1RA) intron 2 86 bp repeat and interleukin-4 (IL4) intron 3 70 bp repeat are variable number tandem repeats (VNTRs) that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association ofIL1RAandIL4VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions ofIL1RAandIL4were significantly different among ethnicities, and the alleles were associated with total body fat (TBF) classes. Individuals withIL1RAI/II genotype or allele II had greater risk of having higher overall adiposity, relative to those having the I/I genotype or I allele, respectively, even after controlling for ethnicity [Odds Ratio (OR) of I/II genotype = 12.21 (CI = 2.54, 58.79;p=0.002); II allele = 5.78 (CI = 1.73, 19.29;p=0.004)]. However,IL4VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity [OR = 1.53 (CI = 1.04, 2.23;p=0.03)]. Individuals withIL1RAII allele had significantly higher TBF than those with I allele (31.79±2.52versus23.51±0.40;p=0.005). Taken together,IL1RAintron 2 VNTR seems to be a genetic marker for overall adiposity status in Malaysian subjects.

scholarly journals IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Zornitsa Kamenarska ◽  
Gyulnas Dzhebir ◽  
Maria Hristova ◽  
Alexey Savov ◽  
Anton Vinkov ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Receptor Antagonist ◽  
Lupus Erythematosus ◽  
Interleukin 1 ◽  
Variable Number Tandem Repeat ◽  
Variable Number ◽  
Systemic Lupus ◽  
Vntr Polymorphism ◽  
Interleukin 1 Receptor Antagonist ◽  
Control Study

Polymorphisms in the cytokine genes and their natural antagonists are thought to influence the predisposition to dermatomyositis (DM) and systemic lupus erythematosus (SLE). A variable number tandem repeat (VNTR) polymorphism of 86 bp in intron 2 of the interleukin-1 receptor antagonist (IL-1RN) gene leads to the existence of five different alleles which cause differences in the production of both IL-1RA (interleukin-1 receptor antagonist) and IL-1β. The aim of this case-control study was to investigate the association between the IL-1RN VNTR polymorphism and the susceptibility to DM and SLE in Bulgarian patients. Altogether 91 patients, 55 with SLE and 36 with DM, as well as 112 unrelated healthy controls, were included in this study. Only three alleles were identified in both patients and controls ((1) four repeats, (2) two repeats, and (3) five repeats). The IL-1RN*2 allele (P=0.02, OR 2.5, and 95% CI 1.2–5.4) and the 1/2+2/2 genotypes were found prevalent among the SLE patients (P=0.05, OR 2.6, and 95% CI 1–6.3). No association was found between this polymorphism and the ACR criteria for SLE as well as with the susceptibility to DM. Our results indicate that the IL-1RN VNTR polymorphism might play a role in the susceptibility of SLE but not DM.

scholarly journals Interleukin 1 receptor antagonist gene variable number of tandem repeats polymorphism and cutaneous melanoma

2019 ◽  
Author(s):  
Sabina Cauci ◽  
Cinzia Buligan ◽  
Francesco Rocchi ◽  
Ilaria Salvador ◽  
Luigi Xodo ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Cutaneous Melanoma ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Variable Number ◽  
Interleukin 1 Receptor Antagonist

Polymorphism in the Interleukin-1 Receptor Antagonist Gene Is Associated with Serum Interleukin-1 Receptor Antagonist Concentrations and Postoperative Opioid Consumption

2011 ◽  
Vol 114 (5) ◽  
pp. 1162-1168 ◽  
Author(s):  
Keith A. Candiotti ◽  
Zongqi Yang ◽  
Richard Morris ◽  
Jinfeng Yang ◽  
Nicolas A. Crescimone ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeats ◽  
Polymerase Chain Reaction Amplification ◽  
Interleukin 1 ◽  
Variable Number ◽  
Opioid Consumption ◽  
Base Pairs ◽  
Interleukin 1 Receptor Antagonist ◽  
Interindividual Variations ◽  
Intron 2

Background The interleukin-1 receptor antagonist (IL-1Ra) is the principal determinant of IL-1β bioactivity within the IL-1 gene cluster, regulating IL-1α and IL-1β release. This study was designed to determine whether polymorphisms of the IL-1Ra gene (IL1RN) produce clinically measurable differences in serum IL-1Ra concentrations and opioid consumption in the postoperative period. Methods Opioid consumption and pain scores were evaluated in 96 patients undergoing a nephrectomy. DNA was extracted from all patients, and the genotypes of IL1RN were determined by polymerase chain reaction amplification of the variable number of tandem repeats of 86 base pairs in intron 2 of IL1RN. The concentrations of serum IL-1Ra concentrations at baseline and at 24 h postoperatively in 58 subjects were measured. Results Differences in opioid consumption among the three genotype groups (IL1RN*1 homozygotes and *2 and *3 carriers) were statistically significant in the first and second 12-h postoperative periods (P = 0.010). The IL1RN*2 carrier group consumed 43% (95% CI, 38-48%) less opioids in the first 24 h after surgery than the IL1RN*1 homozygote group (P = 0.003). Differences in the serum IL-1Ra concentration among the three genotype groups were statistically significant at 24 h postoperatively (P = 0.003), with IL1RN*2 carriers having the highest serum IL-1Ra concentrations. Conclusions The variable number of tandem repeats in intron 2 of IL1RN may contribute to interindividual variations in opioid consumption in the first 24 h after surgery. Patients homozygous for the IL1RN*1 allele have lower concentrations of IL-1Ra and require higher doses of opioids postoperatively than patients carrying at least one IL1RN*2 allele.

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