scholarly journals Interleukin-1 Receptor Antagonist and Interleukin-4 Genes Variable Number Tandem Repeats Are Associated with Adiposity in Malaysian Subjects

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Yung-Yean Kok ◽  
Hing-Huat Ong ◽  
Yee-How Say
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Variable Number ◽  
Interleukin 4 ◽  
Ethnic Chinese ◽  
Interleukin 1 Receptor Antagonist ◽  
Total Body ◽  
Variable Number Tandem Repeats ◽  
Intron 2

Interleukin-1 receptor antagonist (IL1RA) intron 2 86 bp repeat and interleukin-4 (IL4) intron 3 70 bp repeat are variable number tandem repeats (VNTRs) that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association ofIL1RAandIL4VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions ofIL1RAandIL4were significantly different among ethnicities, and the alleles were associated with total body fat (TBF) classes. Individuals withIL1RAI/II genotype or allele II had greater risk of having higher overall adiposity, relative to those having the I/I genotype or I allele, respectively, even after controlling for ethnicity [Odds Ratio (OR) of I/II genotype = 12.21 (CI = 2.54, 58.79;p=0.002); II allele = 5.78 (CI = 1.73, 19.29;p=0.004)]. However,IL4VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity [OR = 1.53 (CI = 1.04, 2.23;p=0.03)]. Individuals withIL1RAII allele had significantly higher TBF than those with I allele (31.79±2.52versus23.51±0.40;p=0.005). Taken together,IL1RAintron 2 VNTR seems to be a genetic marker for overall adiposity status in Malaysian subjects.

scholarly journals Interleukin-1 Receptor Antagonist (IL1RA) and Interleukin-4 (IL4) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects

2017 ◽  
Author(s):  
Yung-Yean Kok ◽  
Hing-Huat Ong ◽  
Yee-How Say
Keyword(s):  
Odds Ratio ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Variable Number ◽  
Interleukin 4 ◽  
Ethnic Chinese ◽  
Total Body Fat ◽  
Total Body ◽  
Variable Number Tandem Repeats ◽  
Intron 2

IL1RA intron 2 86-bp repeat and IL4 intron 3 70-bp repeat are VNTRs that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association of IL1RA and IL4 VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions of IL1RA and IL4 were significantly different among ethnicities, and the alleles were associated with total body fat (TBF) classes. Individuals with IL1RA I/II genotype or allele II had greater risk of having higher adiposity - even after controlling for ethnicity [Odds Ratio (OR) of I/II genotype = 12.21 (CI = 2.54, 58.79; p = 0.002); II allele = 5.78 (CI = 1.73, 19.29; p = 0.004)]. However, IL4 VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity [OR = 1.53 (CI = 1.04, 2.23; p = 0.03)]. TBF was also significantly higher in those with IL1RA II allele compared with I allele (31.79 ± 2.52 vs. 23.51 ± 0.40; p = 0.005). Taken together, IL1RA intron 3 VNTR seems to be a genetic marker for overall adiposity status in Malaysian subjects.

Polymorphism in the Interleukin-1 Receptor Antagonist Gene Is Associated with Serum Interleukin-1 Receptor Antagonist Concentrations and Postoperative Opioid Consumption

2011 ◽  
Vol 114 (5) ◽  
pp. 1162-1168 ◽  
Author(s):  
Keith A. Candiotti ◽  
Zongqi Yang ◽  
Richard Morris ◽  
Jinfeng Yang ◽  
Nicolas A. Crescimone ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeats ◽  
Polymerase Chain Reaction Amplification ◽  
Interleukin 1 ◽  
Variable Number ◽  
Opioid Consumption ◽  
Base Pairs ◽  
Interleukin 1 Receptor Antagonist ◽  
Interindividual Variations ◽  
Intron 2

Background The interleukin-1 receptor antagonist (IL-1Ra) is the principal determinant of IL-1β bioactivity within the IL-1 gene cluster, regulating IL-1α and IL-1β release. This study was designed to determine whether polymorphisms of the IL-1Ra gene (IL1RN) produce clinically measurable differences in serum IL-1Ra concentrations and opioid consumption in the postoperative period. Methods Opioid consumption and pain scores were evaluated in 96 patients undergoing a nephrectomy. DNA was extracted from all patients, and the genotypes of IL1RN were determined by polymerase chain reaction amplification of the variable number of tandem repeats of 86 base pairs in intron 2 of IL1RN. The concentrations of serum IL-1Ra concentrations at baseline and at 24 h postoperatively in 58 subjects were measured. Results Differences in opioid consumption among the three genotype groups (IL1RN*1 homozygotes and *2 and *3 carriers) were statistically significant in the first and second 12-h postoperative periods (P = 0.010). The IL1RN*2 carrier group consumed 43% (95% CI, 38-48%) less opioids in the first 24 h after surgery than the IL1RN*1 homozygote group (P = 0.003). Differences in the serum IL-1Ra concentration among the three genotype groups were statistically significant at 24 h postoperatively (P = 0.003), with IL1RN*2 carriers having the highest serum IL-1Ra concentrations. Conclusions The variable number of tandem repeats in intron 2 of IL1RN may contribute to interindividual variations in opioid consumption in the first 24 h after surgery. Patients homozygous for the IL1RN*1 allele have lower concentrations of IL-1Ra and require higher doses of opioids postoperatively than patients carrying at least one IL1RN*2 allele.

scholarly journals Interleukin 1 receptor antagonist gene variable number of tandem repeats polymorphism and cutaneous melanoma

2019 ◽  
Author(s):  
Sabina Cauci ◽  
Cinzia Buligan ◽  
Francesco Rocchi ◽  
Ilaria Salvador ◽  
Luigi Xodo ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Cutaneous Melanoma ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Variable Number ◽  
Interleukin 1 Receptor Antagonist

A gender-specific association of interleukin 1 receptor antagonist polymorphism with schizophrenia susceptibility

2013 ◽  
Vol 25 (6) ◽  
pp. 349-355 ◽  
Author(s):  
Mouna Ben Nejma ◽  
Ines Zaabar ◽  
Ferid Zaafrane ◽  
Sihem Thabet ◽  
Anouar Mechri ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Receptor Antagonist ◽  
Patient Group ◽  
Interleukin 1 ◽  
Tunisian Population ◽  
Control Group ◽  
Altered Level ◽  
Interleukin 1 Receptor Antagonist ◽  
Increased Risk ◽  
Intron 2

ObjectiveRecent genetic studies have revealed that the interleukin (IL) 1 gene complex is associated with schizophrenia in the Caucasian population; however, data from the North African population are limited. To further assess the role of interleukin 1 receptor antagonist protein (IL1Ra) in schizophrenia, we examined a functional multiallelic polymorphism localised in intron 2 of this receptor gene associated with an altered level of IL1Ra.MethodsIn the present case–control study, we have analysed the (86 bp)npolymorphism of the interleukin 1 receptor antagonist (IL1RN) gene (RS 1794068) by polymerase chain reaction genotyping in 259 patients with schizophrenia and 178 healthy controls from the Tunisian population.ResultsWe showed that the frequencies of the IL1RN*2/2 genotype and allele 2 were higher in the patient group compared with the control group, and the difference was statistically significant [13.5% vs. 5.6%,p= 10−3, odds ratio (OR) = 3.2% and 32.8% vs. 21.9%,p= 3 × 10−4, OR = 1.76, respectively). When we evaluated the association between this genetic polymorphism and the clinical variables of schizophrenia, we found that the frequencies of the 2/2 genotype and allele 2 were significantly higher in the male patient group (p= 10−4and 10−5, respectively) compared with the male control group, indicating a substantially increased risk for sex-onset schizophrenia with inheritance of the IL1RN2 allele. When the association between the genotypes and outcome was evaluated by multiple logistic regression analysis, the adjusted OR for the IL1RN genotypes remained statistically significant [1.39; 95% confidence interval (CI) = 1.11–1.73;p= 0.003].ConclusionThe intron 2 polymorphism in IL1RN or a genetic polymorphism at proximity seems to be associated specifically with schizophrenia in the Tunisian male population.

Sign in / Sign up

Export Citation Format

Share Document