The interleukin-1 receptor antagonist gene: a single-copy variant of the intron 2 variable number tandem repeat (VNTR) polymorphism

2002 ◽  
Vol 29 (4) ◽  
pp. 337-340 ◽  
Author(s):  
J. E. Vamvakopoulos ◽  
C. J. Taylor ◽  
G. J. Morris-Stiff ◽  
C. Green ◽  
S. Metcalfe
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeat ◽  
Interleukin 1 ◽  
Variable Number Tandem Repeat ◽  
Single Copy ◽  
Variable Number ◽  
Vntr Polymorphism ◽  
Interleukin 1 Receptor Antagonist ◽  
Intron 2

scholarly journals IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Zornitsa Kamenarska ◽  
Gyulnas Dzhebir ◽  
Maria Hristova ◽  
Alexey Savov ◽  
Anton Vinkov ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Receptor Antagonist ◽  
Lupus Erythematosus ◽  
Interleukin 1 ◽  
Variable Number Tandem Repeat ◽  
Variable Number ◽  
Systemic Lupus ◽  
Vntr Polymorphism ◽  
Interleukin 1 Receptor Antagonist ◽  
Control Study

Polymorphisms in the cytokine genes and their natural antagonists are thought to influence the predisposition to dermatomyositis (DM) and systemic lupus erythematosus (SLE). A variable number tandem repeat (VNTR) polymorphism of 86 bp in intron 2 of the interleukin-1 receptor antagonist (IL-1RN) gene leads to the existence of five different alleles which cause differences in the production of both IL-1RA (interleukin-1 receptor antagonist) and IL-1β. The aim of this case-control study was to investigate the association between the IL-1RN VNTR polymorphism and the susceptibility to DM and SLE in Bulgarian patients. Altogether 91 patients, 55 with SLE and 36 with DM, as well as 112 unrelated healthy controls, were included in this study. Only three alleles were identified in both patients and controls ((1) four repeats, (2) two repeats, and (3) five repeats). The IL-1RN*2 allele (P=0.02, OR 2.5, and 95% CI 1.2–5.4) and the 1/2+2/2 genotypes were found prevalent among the SLE patients (P=0.05, OR 2.6, and 95% CI 1–6.3). No association was found between this polymorphism and the ACR criteria for SLE as well as with the susceptibility to DM. Our results indicate that the IL-1RN VNTR polymorphism might play a role in the susceptibility of SLE but not DM.

Analysis Of İnterleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitis

2020 ◽  
Vol 20 ◽  
Author(s):  
Akin Tekcan ◽  
Serbulent Yigit ◽  
Ayse F. Nursal ◽  
Mehmet K. Tumer ◽  
Kaan Yerliyurt ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeat ◽  
Interleukin 1 ◽  
Variable Number Tandem Repeat ◽  
Variable Number ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Genotype Distribution ◽  
Healthy Controls ◽  
Interleukin 1 Receptor Antagonist

Background/Aims: Recurrent aphthous stomatitis (RAS) is one of common oral inflammatory diseases. As immunological and genetic factors have been held in the pathogenesis of RAS, the objective of this study was to determine whether the interleukin-1 receptor antagonist (IL-1Ra) gene variable number tandem repeat (VNTR) variant is a risk factor for the development of RAS in Turkish patients and to define its contribution to the increased risk. Methods: The IL-1Ra VNTR variant was evaluated in 169 RAS patients and 171 healthy controls by the polymerase chain reaction (PCR) method. Results: No statistically significant difference was found in the genotype distribution and allelic frequencies of IL-1Ra VNTR variant between RAS patients and healthy controls. Conclusion: Lack of association between IL-1Ra VNTR variant and RAS could indicate that IL-1Ra has no significant role in pathophysiology of RAS. However, it still appears to be very worthwhile to continue to search for cytokine gene variants in order to predict the development of such disease.

scholarly journals Interleukin-1 Receptor Antagonist and Interleukin-4 Genes Variable Number Tandem Repeats Are Associated with Adiposity in Malaysian Subjects

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Yung-Yean Kok ◽  
Hing-Huat Ong ◽  
Yee-How Say
Keyword(s):  
Receptor Antagonist ◽  
Tandem Repeats ◽  
Interleukin 1 ◽  
Variable Number ◽  
Interleukin 4 ◽  
Ethnic Chinese ◽  
Interleukin 1 Receptor Antagonist ◽  
Total Body ◽  
Variable Number Tandem Repeats ◽  
Intron 2

Interleukin-1 receptor antagonist (IL1RA) intron 2 86 bp repeat and interleukin-4 (IL4) intron 3 70 bp repeat are variable number tandem repeats (VNTRs) that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association ofIL1RAandIL4VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions ofIL1RAandIL4were significantly different among ethnicities, and the alleles were associated with total body fat (TBF) classes. Individuals withIL1RAI/II genotype or allele II had greater risk of having higher overall adiposity, relative to those having the I/I genotype or I allele, respectively, even after controlling for ethnicity [Odds Ratio (OR) of I/II genotype = 12.21 (CI = 2.54, 58.79;p=0.002); II allele = 5.78 (CI = 1.73, 19.29;p=0.004)]. However,IL4VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity [OR = 1.53 (CI = 1.04, 2.23;p=0.03)]. Individuals withIL1RAII allele had significantly higher TBF than those with I allele (31.79±2.52versus23.51±0.40;p=0.005). Taken together,IL1RAintron 2 VNTR seems to be a genetic marker for overall adiposity status in Malaysian subjects.

scholarly journals Association of Intron-2 Variable Numbers of an 86-bp Tandem Repeat- Polymorphisms of Interleukin-1 Receptor Antagonist Gene and Idiopathic Recurrent Spontaneous Abortion

2018 ◽  
Vol 70 (2) ◽  
Author(s):  
Marco Antonio Avila-Vergara ◽  
Felipe de Jesús Peraza-Garay ◽  
Noemí Meraz-Cruz ◽  
Cesar Hernandez-Guerrero ◽  
Berenice Palacios-Gonzalez ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Spontaneous Abortion ◽  
Tandem Repeat ◽  
Interleukin 1 ◽  
Recurrent Spontaneous Abortion ◽  
Interleukin 1 Receptor Antagonist ◽  
Intron 2
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