scholarly journals Lymph node metastasis around the entrance point to recurrent laryngeal nerve in papillary thyroid carcinoma

2019 ◽  
Author(s):  
Tian Lv ◽  
Zhuoran Liu ◽  
Jiqi Yan
Keyword(s):  
Lymph Node ◽  
Recurrent Laryngeal Nerve ◽  
Tumor Location ◽  
Nodal Metastasis ◽  
Laryngeal Nerve ◽  
Surrounding Tissue ◽  
Papillary Thyroid ◽  
Tumor Multifocality ◽  
Upper Third ◽  
Central Nodal Metastasis

Abstract Background There were few reports on the lymph nodes of entrance point to recurrent laryngeal nerve (LN-epRLN) in patients with papillary thyroid carcinoma (PTC). Therefore, we aimed to increase awareness of LN-epRLN. Methods A prospective analysis including 878 consecutive patients with PTC who underwent thyroidectomy from April 2016 to March 2017 was performed. We explored the surrounding tissue of entrance point to recurrent laryngeal nerve, during routine central lymph node dissection (CLND). The lymph node specimens were sent separately for routine histopathological examination, and the complications and follow-ups were recorded. Results LN-epRLN was found in 73 of the 878 patients and the metastasis rate was 3.76%. In univariate analysis, LN-epRLN metastasis was correlated with further central nodal metastasis, tumor location in the upper third of the thyroid and tumor multifocality. Conclusions LN-epRLN can be the site of metastasis of PTC. CLND scope should include the surrounding tissue of entrance point to recurrent laryngeal nerve. LN-epRLN metastasis in PTC is associated with tumor location in the isthmus or upper third of the thyroid, tumor multifocality and further central nodal metastasis.

scholarly journals Lymph node metastasis around the entrance point to recurrent laryngeal nerve in papillary thyroid carcinoma

2019 ◽  
Author(s):  
Tian Lv ◽  
Zhuoran Liu ◽  
Jie Kuang ◽  
Jiqi Yan
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Recurrent Laryngeal Nerve ◽  
Tumor Location ◽  
Nodal Metastasis ◽  
Laryngeal Nerve ◽  
Papillary Thyroid ◽  
Tumor Multifocality ◽  
Upper Third ◽  
Central Nodal Metastasis

Abstract Background: There were few reports on the lymph nodes of entrance point to recurrent laryngeal nerve (LN-epRLN) in the patients with papillary thyroid carcinoma (PTC). Therefore, we aimed to increase acknowledgement of LN-epRLN and explore clinical implication. Methods: A prospective analysis including 878 consecutive patients with PTC who underwent thyroidectomy from April 2016 to March 2017 was performed. We explored the surrounding tissue of entrance point to recurrent laryngeal nerve, during routine central lymph node dissection (CLND). The lymph node specimens were sent separately for routine histopathological examination, and the complications and follow-ups were recorded. Results: LN-epRLN was found in 73 of the 878 patients and the metastasis rate was 3.76%. In univariate analysis, LN-epRLN metastasis was correlated with further central nodal metastasis, tumor location in the upper third of the thyroid and tumor multifocality. Conclusions: LN-epRLN can be the site of metastasis of PTC, and the positive LN-epRLN was highly predictive of other central nodal metastasis. LN-epRLN metastases in PTC were also associated with tumor location in the isthmus or upper third of the thyroid and tumor multifocality. In our study, we focus on acknowledgement of LN-epRLN. We emphasized the value of exactitude anatomy and the thoroughness of CLND for cN0-1a PTC.

scholarly journals Lymph node metastasis around the entrance point to recurrent laryngeal nerve in papillary thyroid carcinoma

2020 ◽  
Author(s):  
Tian Lv ◽  
Zhuoran Liu ◽  
Jie Kuang ◽  
Jiqi Yan
Keyword(s):  
Lymph Node ◽  
Recurrent Laryngeal Nerve ◽  
Tumor Location ◽  
Nodal Metastasis ◽  
Laryngeal Nerve ◽  
Central Lymph Node ◽  
Tumor Multifocality ◽  
Central Lymph ◽  
Upper Third ◽  
Central Nodal Metastasis

Abstract Background: There were are few reports on the lymph nodes of entrance point to recurrent laryngeal nerve (LN-epRLN) in the patients with papillary thyroid carcinoma (PTC). Therefore,Thus, we investigated the clinical significance of aimed to increase acknowledgement of LN-epRLN and implications it may have.explore clinical implication. Methods: A prospective observational analysis including of 878 consecutive patients with PTC who underwent thyroidectomy from April 2016 to March 2017 was conductedperformed. We explored the surrounding tissue of laryngeal entry pointentrance point to recurrent laryngeal nerve, during routine central lymph node dissection (CLND). The lymph node specimens were sent separately for routine histopathological examination. Thereafter, , and the complications and follow-ups were recorded. Results: LN-epRLNs was were found in 73 of the 878 patients, with and the metastasis metastatic rate of was 3.76%. In univariate analysis, LN-epRLN metastasis was correlated with further central nodal metastasis, tumor location in the upper third of the thyroid and tumor multifocality. Univariate and multivariate analysis showed central lymph node metastases can serve as independent predictors for LN-epRLN metastasis. Conclusions: LN-epRLN can be the site of metastasis of PTC, and the positive LN-epRLN was highly predictive of other central nodal metastasis. LN-epRLN metastases in PTC were also associated with tumor location in the isthmus or upper third of the thyroid and tumor multifocality. In our study, we focus on acknowledgement of LN-epRLN. We emphasized the value of exactitude anatomy and the thoroughness of CLND for cN0-1a PTC.In summary, we confirmed the significance of LN-epRLN in metastasis and recurrence, which required precise anatomy and thorough CLND. In PTC patients, especially in suspicious presence of central cervical lymph node metastasis, attention should be given to excising the nodal tissue at the laryngeal entry point.

366 CLINICAL NOMOGRAM MODEL FOR RECURRENT LARYNGEAL NERVE LYMPH NODE METASTASIS IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA: A RETROSPECTIVE MULTICENTER STUDY

2020 ◽  
Vol 33 (Supplement_1) ◽  
Author(s):  
D Tian ◽  
X He ◽  
Y Yang ◽  
L Chen
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Recurrent Laryngeal Nerve ◽  
Tumor Size ◽  
Tumor Location ◽  
Laryngeal Nerve ◽  
Tumor Differentiation ◽  
Node Metastasis ◽  
T Stage ◽  
Positive Groups

Abstract   Recurrent laryngeal nerve lymph node metastasis (RLN LNM) is not rare in patients with esophageal cancer. We aimed to explore the risk factors for RLN LNM and to develop a nomogram predicting the likelihood of RLN LNM in esophageal squamous cell carcinoma (ESCC) patients. Methods We retrospectively reviewed patients with ESCC who underwent esophagectomy as well as recurrent laryngeal nerve lymph node dissection between May 2015 and February 2019 at two different institutions. The patients were divided into negative and positive groups according to the presence of RLN LNM. Risk factors for RLN LNM were evaluated by univariate and multivariate analyses. A nomogram was constructed for presentation of the final model. Results A total of 390 patients with ESCC were included in this study. The differences in tumor location, tumor differentiation, T stage, tumor size and carcinoembryonic antigen (CEA) between the negative (N = 270) and positive groups (N = 120) RLN LNM were significant (P < 0.05). Multivariate analysis indicated that the tumor location (OR = 0.520, 95% CI: 0.361–0.749, P < 0.001), tumor differentiation (OR = 2.279, 95% CI: 1.586–3.276, P < 0.001), T stage (OR = 1.436, 95% CI: 1.029–2.003, P = 0.033), tumor size (OR = 1.781, 95% CI: 1.021–3.106, P = 0.042) and CEA (OR = 1.206, 95% CI: 1.003–1.450, P = 0.046) were independent risk factors for RLN LNM. A nomogram with these variables had good predictive accuracy (c-index: 0.716). Conclusion Tumor location, tumor differentiation, T stage, tumor size and CEA may predict the risk of RLN LNM. We created a nomogram predicting the likelihood of RLN LNM in patients with ESCC.

scholarly journals Clinical Outcomes of T4a Papillary Thyroid Cancer With Recurrent Laryngeal Nerve Involvement: A Retrospective Analysis

2020 ◽  
Author(s):  
Han-Seul Na ◽  
Hyun-Keun Kwon ◽  
Sung-Chan Shin ◽  
Yong-Il Cheon ◽  
Myeonggu Seo ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Recurrent Laryngeal Nerve ◽  
Vocal Cord ◽  
Papillary Thyroid Cancer ◽  
Recurrence Rate ◽  
Laryngeal Nerve ◽  
Papillary Thyroid ◽  
Clinical Factors ◽  
Esophageal Invasion

Abstract Preoperative vocal cord palsy (VCP) may indicate locally invasive papillary thyroid cancer (PTC); using this relationship, we evaluated the clinical outcomes and risk factors for recurrence in post-thyroidectomy T4a PTC patients with recurrent laryngeal nerve (RLN) involvement. We retrospectively investigated thyroidectomy patients, recorded their clinical factors, recurrence rate, and pathological findings, and analysed the relationship between recurrence rate and clinical factors. Of 72 patients, 37 (51%) had preoperative VCP and 35 (49%) had normal preoperative vocal cord movement with confirmed intraoperative RLN invasion. Tracheal and esophageal invasion was observed in 13 (18%) and 15 (21%) patients, respectively. Thyroid cancer recurred in 18 (25%) patients over 58 months, resulting in 2 (3%) deaths. Recurrence was not associated with surgical extent, organ invasion, enlarged tumour size, or lymph node infiltration (p > 0.05). The recurrence rate was significantly higher in patients with positive resection margins (p < 0.05). T4a PTC patients with RLN involvement showed a poor prognosis. The recurrence rate was not affected by preoperative VCP, intraoperative detection of RLN invasion, nerve resection, nerve preservation by shaving, lymph node metastasis, or tracheal or esophageal invasion. The most important prognostic factor for recurrence was a positive resection margin.

scholarly journals A NOVEL SCORING SYSTEM FOR RISK OF PAPILLARY THYROID CANCER METASTASES IN LYMPH NODES POSTERIOR TO THE RIGHT OF THE RECURRENT LARYNGEAL NERVE

2020 ◽  
Author(s):  
Jianbo Li ◽  
Gaofei He ◽  
Yifan Tong ◽  
Li Tao ◽  
Lei Xie ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Recurrent Laryngeal Nerve ◽  
Scoring System ◽  
Central Compartment ◽  
Laryngeal Nerve ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
The Right ◽  
Development And Validation

Background: Papillary thyroid carcinoma (PTC) can frequently metastasize to the cervical lymph node, especially in the central compartment. Some surgeons believe that dissection posterior to the right recurrent laryngeal nerve lymph node (PRRLN-LN) is unnecessary because of the low metastasis rate and high complication risk. However, persistent metastatic lymph nodes may have a higher recurrence rate, surgical risk, and complications. Thus, it is important to distinguish patients who require PRRLN-LN dissection. The aim of this study was to identify the risk factors for PRRLN-LN metastasis (LN-prRLN), and to establish a scoring system, to help determine whether PRRLN-LN dissection is required in PTC patients. Methods: The study comprised 821 patients with primary PTC in the right or both lobes who had undergone right lobectomy or total thyroidectomy with only right, or bilateral central compartment dissection with/without lateral neck dissection, between January 2010 and June 2016 in our institution. Participants were randomly allocated to development and validation cohorts in a 2:1 ratio. A nomogram-based predictive model for LN-prRLN was established based on the risk factors identified in the development cohort. Results: LN-prRLN was diagnosed pathologically in 15.1% (124/821) of patients from the entire cohort. Multivariate analysis identified age (odds ratio [OR] 0.964, 95% confidence interval [CI] 0.945–0.983; P<0.001), tumor size (OR 1.536, 95%CI 1.135–2.079; P=0.005), extrathyroidal extension (OR 2.271, 95%CI 1.368–3.770; P=0.002), clinically-involved right central compartment lymph node metastasis (OR 1.643, 95%CI 1.055–2.559; P=0.028), and right lateral lymph node metastasis (OR 4.271, 95%CI 2.325–7.844; P<0.001) as predictors of LN-prRLN. A risk model was established and well validated. Calibration curves to evaluate the nomogram in both the development and validation cohorts revealed a C-index of 0.756±0.058 and 0.745±0.042, respectively. Conclusions: Our scoring system may be useful for helping surgeons to decide which patients should undergo dissection of the PRRLN-LN. Abbreviations: ATA = American Thyroid Association; CCD = Central compartment dissection; CI = Confidence interval; C-index = The concordance index; ETE = Extrathyroidal extension; FNA = Fine-needle aspiration; LNM = Lymph node metastasis; LN-prRLN = Posterior to the right recurrent laryngeal nerve lymph node metastasis; OR = Odds ratio; PRRLN-LN = Posterior to the right recurrent laryngeal nerve lymph node; PTC = Papillary thyroid carcinoma; RLN = Recurrent laryngeal nerve.

scholarly journals Clinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Han-Seul Na ◽  
Hyun-Keun Kwon ◽  
Sung-Chan Shin ◽  
Yong-Il Cheon ◽  
Myeonggu Seo ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Recurrent Laryngeal Nerve ◽  
Vocal Cord ◽  
Papillary Thyroid Cancer ◽  
Recurrence Rate ◽  
Laryngeal Nerve ◽  
Papillary Thyroid ◽  
Clinical Factors ◽  
Esophageal Invasion

AbstractPreoperative vocal cord palsy (VCP) may indicate locally invasive papillary thyroid cancer (PTC); using this relationship, we evaluated the clinical outcomes and risk factors for recurrence in post-thyroidectomy T4a PTC patients with recurrent laryngeal nerve (RLN) involvement. We retrospectively investigated thyroidectomy patients, recorded their clinical factors, recurrence rate, and pathological findings, and analysed the relationship between recurrence rate and clinical factors. Of 72 patients, 37 (51%) had preoperative VCP and 35 (49%) had normal preoperative vocal cord movement with confirmed intraoperative RLN invasion. Tracheal and esophageal invasion was observed in 13 (18%) and 15 (21%) patients, respectively. Thyroid cancer recurred in 18 (25%) patients over 58 months, resulting in 2 (3%) deaths. Recurrence was not associated with surgical extent, organ invasion, enlarged tumour size, or lymph node infiltration (p > 0.05). The recurrence rate was significantly higher in patients with positive resection margins (p < 0.05). T4a PTC patients with RLN involvement showed a poor prognosis. The recurrence rate was not affected by preoperative VCP, intraoperative detection of RLN invasion, nerve resection, nerve preservation by shaving, lymph node metastasis, or tracheal or esophageal invasion. The most important prognostic factor for recurrence was a positive resection margin.

scholarly journals Metastasis of cN0 Papillary Thyroid Carcinoma of the Isthmus to the Lymph Node Posterior to the Right Recurrent Laryngeal Nerve

2021 ◽  
Vol 12 ◽  
Author(s):  
Wei Du ◽  
Qigen Fang ◽  
Xu Zhang ◽  
Liyuan Dai
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Recurrent Laryngeal Nerve ◽  
Central Neck Dissection ◽  
Laryngeal Nerve ◽  
Safe Procedure ◽  
Papillary Thyroid ◽  
The Status ◽  
The Right

ObjectiveThe association between metastasis to the lymph node posterior to the right recurrent laryngeal nerve (LN-prRLN) and cN0 papillary thyroid carcinoma (PTC) located in the thyroid isthmus remains unknown; therefore, our goal was to analyze the characteristics of LN-prRLN metastasis of cN0 PTCs of the thyroid isthmus and determine its potential predictors.Patients and methodsThis retrospective study included patients who underwent bilateral central neck dissection between January 2018 and January 2021. The specimen was divided into five groups of prelaryngeal lymph node (LN), pretracheal LN, left paratracheal LN, lymph node anterior to the right recurrent laryngeal nerve (LN-arRLN), and LN-prRLN. Univariate and multivariate analyses were used to assess the association between the clinical pathologic variables and LN-prRLN metastases. Surgical complications were presented descriptively.ResultsA total of 357 patients were included, LN-prRLN metastasis occurred in 23 (6.4%) patients, and LN-prRLN was positive only when there were other LN metastases, especially LN-arRLN metastases. Other independent risk factors for LN-prRLN included foci numbers ≥2, tumor size ≥5.0 mm, and extrathyroidal extensions. The rates of permanent hypoparathyroidism and vocal cord paralysis were 1.1% and 2.0%, respectively.ConclusionLN-prRLN metastases should not be ignored in cN0 PTC located in the thyroid isthmus; however, its dissection is a safe procedure, and the status of LN-arRLN can be a reliable predictor for LN-prRLN metastases.

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