Influence of CMTM8 polymorphisms on Lung cancer susceptibility in the Chinese Han population

Abstract Abstract Background: Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regulated in lung cancer. The objective of this research was to assess the association of CMTM8 genetic polymorphisms with lung cancer risk in Chinese Han population. Methods: To evaluate the correlation between CMTM8 polymorphisms and lung cancer risk, Agena MassArray platform was used for genotype determination among 509 lung cancer patients and 506 controls. Multiple genetic models, stratification analysis and haploview analysis were used by calculating odds ratio (OR) and 95% confidence intervals (CIs). Results: Significant associations were detected between CMTM8 rs6771238 and an increased lung cancer risk (p < 0.05). In stratified analysis, rs6771238 was related to an increased risk of lung squamous cell carcinoma (p < 0.05), rs6771238 was associated with an increased risk of lung adenocarcinoma (p < 0.05), rs9835916 and rs1077868 were correlated with lung cancer staging (p < 0.05), and rs9835916 was correlated with an increased risk of lymph node metastasis in lung cancer patients (p < 0.05). Additionally, Haplotype analysis illuminated that haplotypes GG and AG were closely correlated with lung cancer staging, and haplotype AG was correlated with an increased lung cancer risk among individuals older than 50 years (p < 0.05). Conclusions: Our study firstiy reported that the CMTM8 polymorphisms were risk factors for lung cancer in Chinese Han population. These findings also suggested the potential roles of CMTM8 in the development of lung cancer.

Download Full-text

Influence of CMTM8 polymorphisms on Lung cancer susceptibility in the Chinese Han population

10.21203/rs.2.12045/v1 ◽

2019 ◽

Author(s):

Jiamin Wu ◽

Yao Sun ◽

Zichao Xiong ◽

Fanglin Niu ◽

Yuanwei Liu ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Cancer Patients ◽

Lung Cancer Risk ◽

Cancer Staging ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Lung Cancer Patients ◽

Increased Risk

Abstract Background: Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regulated in lung cancer. The objective of this research was to assess the association of CMTM8 genetic polymorphisms with lung cancer risk in Chinese Han population. Methods: To evaluate the correlation between CMTM8 polymorphisms and lung cancer risk, Agena MassArray platform was used for genotype determination among 509 lung cancer patients and 506 controls. Multiple genetic models, stratification analysis and haploview analysis was used by calculating odds ratio (OR) and 95% confidence intervals (CIs). Results: Significant associations were detected between CMTM8 rs6771238 and an increased lung cancer risk (p < 0.05). In stratified analysis, rs6771238 was related to increased risk of lung squamous cell carcinoma (p < 0.05), rs6771238 was associated with increased risk of lung adenocarcinoma (p < 0.05), rs9835916 and rs1077868 were correlated with lung cancer staging (p < 0.05), and rs9835916 was correlated with increased risk of lymph node metastasis in lung cancer patients (p < 0.05). Additionally, Haplotype analysis illuminated that haplotypes GG and AG were closely correlated with lung cancer staging, and haplotype AG was correlated with increased lung cancer risk among individuals older than 50 years (p < 0.05). Conclusions: Our study first reported that the CMTM8 polymorphisms were risk factors for lung cancer in Chinese Han population. These findings also suggested the potential roles of CMTM8 in the development of lung cancer.

Download Full-text

Influence of CMTM8 polymorphisms on Lung Cancer Susceptibility in the Chinese Han Population

10.21203/rs.3.rs-34577/v1 ◽

2020 ◽

Author(s):

Jiamin Wu ◽

Yao Sun ◽

Zichao Xiong ◽

Fanglin Niu ◽

Yuanwei Liu ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Cancer Patients ◽

Lung Cancer Risk ◽

Lung Squamous Cell Carcinoma ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Lung Cancer Patients ◽

Increased Risk

Abstract Objective: Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regulated in lung cancer. The objective of this research was to assess the association of CMTM8 genetic polymorphisms with lung cancer risk in Chinese Han population.Methods: To evaluate the correlation between CMTM8 polymorphisms and lung cancer risk, Agena MassArray platform was used for genotype determination among 509 lung cancer patients and 506 controls. Multiple genetic models, stratification analysis and haploview analysis was used by calculating odds ratio (OR) and 95% confidence intervals (CIs).Results: Significant associations were detected between CMTM8 rs6771238 and an increased lung cancer risk in codominant (adjusted OR = 1.57, 95%CI: 1.01-2.42, p = 0.044) and dominant (adjusted OR = 1.54, 95%CI: 1.01-2.36, p = 0.047)models. After gender stratification analysis,weobserved that rs6771238 was related to an increased risk of lung squamous cell carcinoma, while rs6771238 was associated with anincreased risk of lung adenocarcinoma. Rs9835916 and rs1077868 were correlated with lung cancer staging.Rs9835916 was linked to increased risk of lymph node metastasis in lung cancer patients. Conclusions: Our study firstly reported that the CMTM8 polymorphisms were a risk factors for lung cancer, which suggested the potential roles of CMTM8 in the development of lung cancerin Chinese Han population.

Download Full-text

Influence of CMTM8 polymorphisms on Lung cancer susceptibility in the Chinese Han population

10.21203/rs.2.12045/v3 ◽

2020 ◽

Author(s):

Jiamin Wu ◽

Xiang Wang ◽

Yao Sun ◽

Zichao Xiong ◽

Fanglin Niu ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Haplotype Analysis ◽

Lung Cancer Risk ◽

Cancer Staging ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Lung Cancer Patients ◽

Increased Risk

Abstract Background: Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regulated in lung cancer. The objective of this research was to assess the association of CMTM8 genetic polymorphisms with lung cancer risk in Chinese Han population. Methods: To evaluate the correlation between CMTM8 polymorphisms and lung cancer risk, Agena MassArray platform was used for genotype determination among 509 lung cancer patients and 506 controls. Multiple genetic models, stratification analysis and haplotype analysis were used by calculating odds ratio (OR) and 95% confidence intervals (CIs). Results: Significant associations were detected between CMTM8 rs6771238 and an increased lung cancer risk ( p < 0.05). In stratified analysis, rs6771238 was related to an increased risk of lung squamous cell carcinoma ( p < 0.05), rs6771238 was associated with an increased risk of lung adenocarcinoma ( p < 0.05), rs9835916 and rs1077868 were correlated with lung cancer staging ( p < 0.05), and rs9835916 was correlated with an increased risk of lymph node metastasis in lung cancer patients ( p < 0.05). Additionally, Haplotype analysis illuminated that haplotypes GG and AG were closely correlated with lung cancer staging, and haplotype AG was correlated with an increased lung cancer risk among individuals older than 50 years ( p < 0.05). Conclusions: Our study firstly reported that the CMTM8 polymorphisms were risk factors for lung cancer in Chinese Han population. These findings also suggested the potential roles of CMTM8 in the development of lung cancer.

Download Full-text

The rs28757157 and rs59429575 polymorphisms in CYP19A1 are associated with lung cancer in Chinese Han population

10.21203/rs.3.rs-25248/v3 ◽

2020 ◽

Author(s):

Chan Zhang ◽

Yujing Cheng ◽

Wanlu Chen ◽

Qi Li ◽

Run Dai ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Lung Cancer Risk ◽

Genetic Model ◽

Protective Role ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Lung Cancer Patients ◽

Functional Studies

Abstract Background: Lung cancer is the leading cause of cancer death globally. Recent studies have revealed that the CYP19A1 gene played a crucial role in cancer initiation and development. The aim of this study was to assess the association of CYP19A1 genetic polymorphisms with the risk of lung cancer in the Chinese Han population. Method: This study randomly recruited 507 lung cancer patients and 505 healthy controls. The genotypes of four SNPs of CYP19A1 gene were identified by Agena MassARRY technique. Genetic model analysis was used to assess the association between genetic variation and lung cancer risk. Odds ratio (OR) values and 95% confidence intervals (CIs) were provided for the evaluation of the lung cancer risk effect. Results: Rs28757157 and rs59429575 polymorphisms of CYP19A1 were significantly correlated with the risk of lung cancer. In stratified analysis, rs28757157 was associated with increased cancer risk in smokers and individuals aged ≤ 60 years. Meanwhile, rs59429575 was identified as a risk biomarker in females and lung adenocarcinoma patients (p < 0.05). While rs28757157 exerted a protective role among people with a BMI greater than 24 (p = 0.033). Conclusions: This study identified two new SNPs (rs28757157 and rs59429575) of CYP19A1 associated with lung cancer in Chinese Han population. These findings provide data support for further functional studies of CYP19A1 in lung cancer.

Download Full-text

The rs28757157 and rs59429575 polymorphisms in CYP19A1 are associated with lung cancer in Chinese Han population

10.21203/rs.3.rs-25248/v2 ◽

2020 ◽

Author(s):

Chan Zhang ◽

Yujing Cheng ◽

Wanlu Chen ◽

Qi Li ◽

Run Dai ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Lung Cancer Risk ◽

Genetic Model ◽

Protective Role ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Lung Cancer Patients ◽

Functional Studies

Abstract Background: Lung cancer is the leading cause of cancer death globally. Recent studies have revealed that the CYP19A1 gene played a crucial role in cancer initiation and development. The aim of this study was to assess the association of CYP19A1 genetic polymorphisms with the risk of lung cancer in the Chinese Han population.Method: This study randomly recruited 507 lung cancer patients and 505 healthy controls. The genotypes of four SNPs of CYP19A1 gene were identified by Agena MassARRY technique. Genetic model analysis was used to assess the association between genetic variation and lung cancer risk. Odds ratio (OR) values and 95% confidence intervals (CIs) were provided for the evaluation of the lung cancer risk effect.Results: Rs28757157 and rs59429575 polymorphisms of CYP19A1 were significantly correlated with the risk of lung cancer. In stratified analysis, rs28757157 was associated with increased cancer risk in smoker and individuals aged ≤60 years. Meanwhile, rs59429575 was identified as a risk biomarker in female and lung adenocarcinoma patients (p < 0.05). While rs28757157 exerted a protective role among people with a BMI greater than 24 (p = 0.033).Conclusions: This study identified two new SNPs (rs28757157 and rs59429575) of CYP19A1 associated with lung cancer in Chinese Han population. These findings provide data support for further functional studies of CYP19A1 in lung cancer.

Download Full-text

The rs28757157 and rs59429575 polymorphisms in CYP19A1 are associated with lung cancer in Chinese Han population

10.21203/rs.3.rs-27422/v1 ◽

2020 ◽

Author(s):

Chan Zhang ◽

Yujing Cheng ◽

Wanlu Chen ◽

Qi Li ◽

Run Dai ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Lung Cancer Risk ◽

Genetic Model ◽

Protective Role ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Lung Cancer Patients ◽

Functional Studies

Abstract Background: Lung cancer is the leading cause of cancer death globally. Recent studies have revealed that the CYP19A1 gene played a crucial role in cancer initiation and development. Objectives: The aim of this study was to assess the association of CYP19A1 genetic polymorphisms with the risk of lung cancer in Chinese Han population. Method: This study randomly recruited 507 lung cancer patients and 505 healthy controls. The genotypes of four SNPs of CYP19A1 gene were identified by Agena MassARRY technique. Genetic model analysis was used to assess the association between genetic variation and lung cancer risk. Odds ratio (OR) values and 95% confidence intervals (CIs) were provided for the evaluation of the lung cancer risk effect. Results: Rs28757157 and rs59429575 polymorphisms of CYP19A1 were significantly correlated with the risk of lung cancer. In stratified analysis, rs28757157 was associated with increased cancer risk in males and smoker. Meanwhile, rs59429575 was identified as a risk biomarker in female and lung adenocarcinoma patients (p < 0.05). While rs28757157 exerted protective role among people with a BMI greater than 24 (p = 0.033). Conclusions: This study identified two new SNPs (rs28757157 and rs59429575) of CYP19A1 associated with lung cancer in Chinese Han population. These findings provide data support for further functional studies of CYP19A1 in lung cancer.

Download Full-text

The rs28757157 and rs59429575 Polymorphisms in CYP19A1 are Associated with Lung Cancer in Chinese Han Population

10.21203/rs.3.rs-25248/v1 ◽

2020 ◽

Author(s):

Chan Zhang ◽

Yujing Cheng ◽

Wanlu Chen ◽

Qi Li ◽

Run Dai ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Lung Cancer Risk ◽

Genetic Model ◽

Protective Role ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Lung Cancer Patients ◽

Functional Studies

Abstract Background Lung cancer is the leading cause of cancer death globally. Recent studies have revealed that the CYP19A1 gene played a crucial role in cancer initiation and development.Objectives The aim of this study was to assess the association of CYP19A1 genetic polymorphisms with the risk of lung cancer in Chinese Han population.Method This study randomly recruited 507 lung cancer patients and 505 healthy controls. The genotypes of four SNPs of CYP19A1 gene were identified by Agena MassARRY technique. Genetic model analysis was used to assess the association between genetic variation and lung cancer risk. Odds ratio (OR) values and 95% confidence intervals (CIs) were provided for the evaluation of the lung cancer risk effect.Results Rs28757157 and rs59429575 polymorphisms of CYP19A1 were significantly correlated with the risk of lung cancer. In stratified analysis, rs28757157 was associated with increased cancer risk in males and smoker. Meanwhile, rs59429575 was identified as a risk biomarker in female and lung adenocarcinoma patients (p < 0.05). While rs28757157 exerted protective role among people with a BMI greater than 24 (p = 0.033).Conclusions This study identified two new SNPs (rs28757157 and rs59429575) of CYP19A1 associated with lung cancer in Chinese Han population. These findings provide data support for further functional studies of CYP19A1 in lung cancer.

Download Full-text

miR-146a and miR-196a-2 genes polymorphisms and its circulating levels in lung cancer patients

The Journal of Biochemistry ◽

10.1093/jb/mvz044 ◽

2019 ◽

Vol 166 (4) ◽

pp. 323-329 ◽

Cited By ~ 2

Author(s):

Randa H Mohamed ◽

Heba F Pasha ◽

Doaa M Gad ◽

Mostafa M Toam

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Cancer Patients ◽

Lung Cancer Risk ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Lung Cancer Patients ◽

Increased Risk ◽

Increase Risk ◽

Circulating Levels

AbstractRecently, MicroRNAs polymorphisms and their serum expression have been linked to increase risk of various cancers. The aim of this study was to elucidate the association between single nucleotide polymorphisms of miR-146a and miR-196a-2 and their serum expression and lung cancer risk. One hundred and twenty lung cancer patients and 120 health controls were included in this study. Genotyping and expression for miR-146a and miR-196a-2 were performed using polymerase chain reaction (PCR)-restriction fragment length polymorphism and quantitative real-time PCR. Individuals carrying miR-146a CG and CC genotypes had significantly increased risk for lung cancer than those carrying miR-146a GG genotype. MiR-146a expression significantly decreased in miR-146a CG and CC genotypes carriers as compared with GG genotype carriers. MiR-196a-2 CT and TT genotypes were significantly associated with increased lung cancer while the highest expression of MiR-196a-2 was detected in miR-196a-2 CC genotype carriers. Serum miR-146a was significantly decreased in lung cancer patients while serum miR-196a-2 expression was significantly increased in lung cancer patients. In conclusion, miR-146a and miR-196a-2 genes polymorphisms and their circulating levels were associated with lung cancer risk in Egyptians and may be helpful in early detection of lung cancer.

Download Full-text