Investigation of Predictability and Influence factors of the Achieved Lenticule Thickness in Small Incision Lenticule Extraction
Abstract Background To evaluate the differences between the predicted and achieved lenticule thickness (ΔLT) after small incision lenticule extraction (SMILE) surgery and investigate relationships between ΔLT and refractive errors or lenticule depth in SMILE. Methods A total of 184 eyes from 184 consecutive patients who underwent SMILE were included in this prospective study. One eye for each patient was randomly selected and included for statistical analysis. An ultrasound pachymetry measurement and Scheimpflug camera corneal topography were obtained before and at 3 months after SMILE. The achieved lenticule thickness was calculated by comparing the preoperative examinations with postoperative examinations using ultrasound pachymetry and Pentacam software measurements. The pupil center and corneal vertex were selected as the 2 locations for measurement calculation on Pentacam. Analysis of variance (ANOVA) was performed to compare mean pachymetry values using different instruments. An independent t test was performed to evaluate the difference in ΔLT between different cap thicknesses. Linear regression analyses were performed between the VisuMax readout lenticule thicknesses and the measured maximum corneal change, the preoperative spherical equivalent (SE) and each ΔLT. Results On average, the achieved lenticule thickness measured with ultrasound pachymetry was 13.02 ± 8.87 μm thinner than the VisuMax readout lenticule thickness. Linear regression analysis showed significant relationships between the predicted and each achieved lenticule thickness. The preoperative SE was significantly related to each ΔLT (ultrasound: R2 =0.279; at corneal vertex: R2 =0.252; at pupil center R2 =0.246). The ΔLT measured by ultrasound pachymetry was significantly smaller in the thick cap group (cap thickness above 120 μm) than in the thin cap group (P < 0.01). Conclusions An overestimation of achieved lenticule thickness was found in this study. The ΔLT was related to the preoperative SE correction. Furthermore a lager ΔLT was found under a thin cap.