scholarly journals Occurrence and determinants of Klebsiella species bloodstream infection in the western interior of British Columbia, Canada

2019 ◽  
Author(s):  
Connor B. Reid ◽  
Lisa Steele ◽  
Kelsey Pasquill ◽  
Elizabeth C. Parfitt ◽  
Kevin Laupland
Keyword(s):  
British Columbia ◽  
Bloodstream Infection ◽  
Burden Of Illness ◽  
Case Fatality ◽  
Population Based ◽  
Hospital Length ◽  
Interquartile Range ◽  
Chronic Obstructive ◽  
Klebsiella Species ◽  
Obstructive Pulmonary Disease

Abstract BACKGROUND: Klebsiella species are among the most common causes of bloodstream infection (BSI). However, few studies have evaluated their epidemiology in non-selected populations. The objective was to define the incidence of, risk factors for, and outcomes from Klebsiella species BSI among residents of the western interior of British Columbia, Canada. METHODS: Population-based surveillance was conducted between April 1, 2010 and March 31, 2017. RESULTS: 151 episodes were identified for an incidence of 12.1 per 100,000 population per year; the incidences of K. pneumoniae and K. oxytoca were 9.1 and 2.9 per 100,000 per year, respectively. Overall 24 (16%) were hospital-onset, 90 (60%) were healthcare-associated, and 37 (25%) were community-associated. The median patient age was 71.4 (interquartile range, 58.8-80.9) years and 88 (58%) cases were males. Episodes were uncommon among patients aged 40 years old and no cases were observed among those aged 10 years. A number of co-morbid medical illnesses were identified as significant risks and included (incidence rate ratio; 95% confidence interval) cerebrovascular accident (5.9; 3.3-9.9), renal disease 4.3; 2.5-7.0), cancer (3.8; 2.6-5.5), congestive heart failure (3.5; 1.6-6.6), dementia (2.9; 1.5-5.2), diabetes mellitus (2.6; 1.7-3.9), and chronic obstructive pulmonary disease (2.3; 1.5-3.5). Of the 141 (93%) patients admitted to hospital, the median hospital length stay was 8 days (interquartile range, 4-17). The in-hospital and 30-day all cause case-fatality rates were 24/141 (17%) and 27/151 (18%), respectively. CONCLUSIONS: Klebsiella species BSI is associated with a significant burden of illness particularly among those with chronic co-morbid illnesses.

scholarly journals Occurrence and determinants of Klebsiella species bloodstream infection in the western interior of British Columbia, Canada

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Connor B. Reid ◽  
Lisa Steele ◽  
Kelsey Pasquill ◽  
Elizabeth C. Parfitt ◽  
Kevin B. Laupland
Keyword(s):  
British Columbia ◽  
Bloodstream Infection ◽  
Burden Of Illness ◽  
Case Fatality ◽  
Population Based ◽  
Hospital Length ◽  
Interquartile Range ◽  
Chronic Obstructive ◽  
Klebsiella Species ◽  
Obstructive Pulmonary Disease

Abstract Background Klebsiella species are among the most common causes of bloodstream infection (BSI). However, few studies have evaluated their epidemiology in non-selected populations. The objective was to define the incidence of, risk factors for, and outcomes from Klebsiella species BSI among residents of the western interior of British Columbia, Canada. Methods Population-based surveillance was conducted between April 1, 2010 and March 31, 2017. Results 151 episodes were identified for an incidence of 12.1 per 100,000 population per year; the incidences of K. pneumoniae and K. oxytoca were 9.1 and 2.9 per 100,000 per year, respectively. Overall 24 (16%) were hospital-onset, 90 (60%) were healthcare-associated, and 37 (25%) were community-associated. The median patient age was 71.4 (interquartile range, 58.8–80.9) years and 88 (58%) cases were males. Episodes were uncommon among patients aged < 40 years old and no cases were observed among those aged < 10 years. A number of co-morbid medical illnesses were identified as significant risks and included (incidence rate ratio; 95% confidence interval) cerebrovascular accident (5.9; 3.3–9.9), renal disease 4.3; 2.5–7.0), cancer (3.8; 2.6–5.5), congestive heart failure (3.5; 1.6–6.6), dementia (2.9; 1.5–5.2), diabetes mellitus (2.6; 1.7–3.9), and chronic obstructive pulmonary disease (2.3; 1.5–3.5). Of the 141 (93%) patients admitted to hospital, the median hospital length stay was 8 days (interquartile range, 4–17). The in-hospital and 30-day all cause case-fatality rates were 24/141 (17%) and 27/151 (18%), respectively. Conclusions Klebsiella species BSI is associated with a significant burden of illness particularly among those with chronic co-morbid illnesses.

scholarly journals Occurrence and determinants of Klebsiella species bloodstream infection in the western interior of British Columbia, Canada

2019 ◽  
Author(s):  
Connor B. Reid ◽  
Lisa Steele ◽  
Kelsey Pasquill ◽  
Elizabeth C. Parfitt ◽  
Kevin Laupland
Keyword(s):  
British Columbia ◽  
Bloodstream Infection ◽  
Burden Of Illness ◽  
Case Fatality ◽  
Population Based ◽  
Hospital Length ◽  
Interquartile Range ◽  
Chronic Obstructive ◽  
Klebsiella Species ◽  
Obstructive Pulmonary Disease

Abstract BACKGROUND Klebsiella species are among the most common causes of bloodstream infection (BSI). However, few studies have evaluated their epidemiology in non-selected populations. The objective was to define the incidence of, risk factors for, and outcomes from Klebsiella species BSI among residents of the western interior of British Columbia, Canada.METHODS Population-based surveillance was conducted between April 1, 2010 and March 31, 2017.RESULTS 151 episodes were identified for an incidence of 12.1 per 100,000 per year; the incidences of K. pneumoniae and K. oxytoca were 9.1 and 2.9 per 100,000 per year, respectively. Overall 24 (16%) were hospital-onset, 90 (60%) were healthcare-associated, and 37 (25%) were community-associated. The median patient age was 71.4 (interquartile range, 58.8-80.9) years and 88 (58%) cases were males. Episodes were uncommon among patients aged ≤40 years old and no cases were observed among those aged ≤ 10 years. A number of co-morbid medical illnesses were identified as significant risks and included (incidence rate ratio; 95% confidence interval) cerebrovascular accident (5.9; 3.3-9.9), renal disease 4.3; 2.5-7.0), cancer (3.8; 2.6-5.5), congestive heart failure (3.5; 1.6-6.6), dementia (2.9; 1.5-5.2), diabetes mellitus (2.6; 1.7-3.9), and chronic obstructive pulmonary disease (2.3; 1.5-3.5). Of the 141 (93%) patients admitted to hospital, the median hospital length stay was 8 days (interquartile range, 4-17). The in-hospital and 30-day all cause case-fatality rates were 24/141 (17%) and 27/151 (18%), respectively.CONCLUSIONS Klebsiella species BSI is associated with a significant burden of illness particularly among those with chronic co-morbid illnesses.

scholarly journals Occurrence and determinants of Klebsiella species bloodstream infection in the western interior of British Columbia, Canada

2019 ◽  
Author(s):  
Connor B. Reid ◽  
Lisa Steele ◽  
Kelsey Pasquill ◽  
Elizabeth C. Parfitt ◽  
Kevin Laupland
Keyword(s):  
British Columbia ◽  
Bloodstream Infection ◽  
Burden Of Illness ◽  
Case Fatality ◽  
Population Based ◽  
Hospital Length ◽  
Interquartile Range ◽  
Chronic Obstructive ◽  
Klebsiella Species ◽  
Obstructive Pulmonary Disease

Abstract BACKGROUND Klebsiella species are among the most common causes of bloodstream infection (BSI). However, few studies have evaluated their epidemiology in non-selected populations. The objective was to define the incidence of, risk factors for, and outcomes from Klebsiella species BSI among residents of the western interior of British Columbia, Canada.METHODS Population-based surveillance was conducted between April 1, 2010 and March 31, 2017.RESULTS 151 episodes were identified for an incidence of 12.1 per 100,000 population per year; the incidences of K. pneumoniae and K. oxytoca were 9.1 and 2.9 per 100,000 per year, respectively. Overall 24 (16%) were hospital-onset, 90 (60%) were healthcare-associated, and 37 (25%) were community-associated. The median patient age was 71.4 (interquartile range, 58.8-80.9) years and 88 (58%) cases were males. Episodes were uncommon among patients aged Common.EditSubmissionSteps.Transform.EquationText 40 years old and no cases were observed among those aged Common.EditSubmissionSteps.Transform.EquationText 10 years. A number of co-morbid medical illnesses were identified as significant risks and included (incidence rate ratio; 95% confidence interval) cerebrovascular accident (5.9; 3.3-9.9), renal disease 4.3; 2.5-7.0), cancer (3.8; 2.6-5.5), congestive heart failure (3.5; 1.6-6.6), dementia (2.9; 1.5-5.2), diabetes mellitus (2.6; 1.7-3.9), and chronic obstructive pulmonary disease (2.3; 1.5-3.5). Of the 141 (93%) patients admitted to hospital, the median hospital length stay was 8 days (interquartile range, 4-17). The in-hospital and 30-day all cause case-fatality rates were 24/141 (17%) and 27/151 (18%), respectively.CONCLUSIONS Klebsiella species BSI is associated with a significant burden of illness particularly among those with chronic co-morbid illnesses.

Population-based laboratory assessment of the burden of community-onset bloodstream infection in Victoria, Canada

2012 ◽  
Vol 141 (1) ◽  
pp. 174-180 ◽  
Author(s):  
K. B. LAUPLAND ◽  
P. C. KIBSEY ◽  
D. B. GREGSON ◽  
J. C. GALBRAITH
Keyword(s):  
Bloodstream Infection ◽  
Burden Of Illness ◽  
Case Fatality ◽  
The Elderly ◽  
Population Based ◽  
Median Length ◽  
Laboratory Assessment ◽  
Acute Hospitalization ◽  
Laboratory Surveillance ◽  
Community Onset

SUMMARYAlthough community-onset bloodstream infection (BSI) is recognized as a major cause of morbidity and mortality, its epidemiology has not been well defined in non-selected populations. We conducted population-based laboratory surveillance in the Victoria area, Canada during 1998–2005 in order to determine the burden associated with community-onset BSI. A total of 2785 episodes were identified for an overall annual incidence of 101·2/100 000. Males and the very young and the elderly were at highest risk. Overall 1980 (71%) episodes resulted in hospital admission for a median length of stay of 8 days; the total days of acute hospitalization associated with community-onset BSI was 28 442 days or 1034 days/100 000 population per year. The in-hospital case-fatality rate was 13%. Community-onset BSI is associated with a major burden of illness. These data support ongoing and future preventative and research efforts aimed at reducing the major impact of these infections.

scholarly journals Burden of Hospitalization Associated with Seasonal Influenza in Toronto, Canada, 2011–2016

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S315-S315
Author(s):  
Taylor Kain ◽  
Brenda L Coleman ◽  
Kazi Hassan ◽  
Karen Green ◽  
Kevin Katz ◽  
...  
Keyword(s):  
Burden Of Illness ◽  
Adult Population ◽  
Case Fatality ◽  
Population Data ◽  
Population Based ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Vaccination Programs ◽  
Statistics Canada ◽  
Research Grant

Abstract Background As indications for testing for influenza broaden, influenza is increasingly being diagnosed in association with hospitalization in adults. We report data on the burden of illness associated with laboratory confirmed influenza requiring hospitalization (LCI-H) in Toronto, Canada from 2010–2011 to 2015–2016. Methods TIBDN has performed population-based surveillance for LCI-H in adults (≥15years) in Toronto and Peel Region, Canada since 2005. All positive tests for influenza are reported, patients are approached for consent and data collected by chart review and patient/physician interview. Death within 30 days of hospitalization was considered associated with influenza. Population data were obtained from Statistics Canada, with data by underlying condition obtained from literature review and provincial health administrative data. Results Over 6 seasons, 5,591 LCI-H episodes were identified: 1,094 (20%) H1N1, 2,847 (51%) H3N2, 415 (7%) A(not typed), 1A(H3N2 and H1N1) and 1,235 (22%) B. The median age of patients was 71.4 years, with 69.3% of patients over 65 years of age; 3,015 (53.4%) were female, 2,618 (46.8%) had been vaccinated against influenza, and 683 (12.2%) were admitted from nursing homes. Incidence by age, influenza subtype and season is shown in Figures 1 and 2. The average annual incidence in healthy adults was 5 per 100,000, compared with 0.8 per 1,000 in adults with COPD or diabetes, 1.7 per 1,000 in adults with cardiac disease, and &gt;2 per 1,000 in those with underlying kidney disease or immunosuppression. Overall, 12.8% of patients had a significant non-respiratory complication (eg. myocarditis, stroke, C. difficile infection). 720 (12.9%) required ICU admission, and 414 (7.4%) required mechanical ventilation. The median hospital length of stay was 9.58 days (IQR 3-11). None of 226 cases aged &lt;30 years died; the case fatality rate increased from 1.8% in those aged 30–39 to 14.5% in those aged 90+ (Figure 3). Conclusion Despite vaccination programs, influenza is a very common cause of hospitalization and death in our adult population. While surveillance for LCI-H underestimates the overall burden of influenza, it may nonetheless help to appropriately prioritize preventive programs. Disclosures J. Powis, Merck: Grant Investigator, Research grant. GSK: Grant Investigator, Research grant. Roche: Grant Investigator, Research grant. Synthetic Biologicals: Investigator, Research grant. A. Mcgeer, Hoffman La Roche: Investigator, Research grant. GSK: Investigator, Research grant. sanofi pasteur: Investigator, Research grant.

scholarly journals Burden of community-onset bloodstream infection: a population-based assessment

2006 ◽  
Vol 135 (6) ◽  
pp. 1037-1042 ◽  
Author(s):  
K. B. LAUPLAND ◽  
D. B. GREGSON ◽  
W. W. FLEMONS ◽  
D. HAWKINS ◽  
T. ROSS ◽  
...  
Keyword(s):  
Bloodstream Infection ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Population Based ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Societal Impact ◽  
Acute Hospitalization ◽  
Laboratory Surveillance ◽  
Community Onset

SUMMARYAlthough community-onset bloodstream infection (BSI) is recognized to be a major cause of morbidity and mortality, there is a paucity of population-based studies defining its overall burden. We conducted population-based laboratory surveillance for all community-onset BSI in the Calgary Health Region during 2000–2004. A total of 4467 episodes of community-onset BSI were identified for an overall annual incidence of 81·6/100 000. The three species,Escherichia coli,Staphylococcus aureus, andStreptococcus pneumoniaewere responsible for the majority of community-onset BSI; they occurred at annual rates of 25·8, 13·5, and 10·1/100 000, respectively. Overall 3445/4467 (77%) episodes resulted in hospital admission representing 0·7% of all admissions to major acute care hospitals. The subsequent hospital length of stay was a median of 9 (interquartile range, 5–15) days; the total days of acute hospitalization attributable to community-onset BSI was 51 146 days or 934 days/100 000 annually. Four hundred and sixty patients died in hospital for a case-fatality rate of 13%. Community-onset BSI is common and has a major patient and societal impact. These data support further efforts to reduce the burden of community-onset BSI.

scholarly journals Occupational cold exposure is associated with increased reporting of airway symptoms

2021 ◽  
Author(s):  
Albin Stjernbrandt ◽  
Nikolai Stenfors ◽  
Ingrid Liljelind
Keyword(s):  
Cold Exposure ◽  
Leisure Time ◽  
Rating Scales ◽  
Binary Logistic Regression ◽  
Population Based ◽  
Postal Survey ◽  
Chronic Obstructive ◽  
Northern Sweden ◽  
Obstructive Pulmonary Disease ◽  
Airway Symptoms

Abstract Objective To determine if exposure to cold environments, during work or leisure time, was associated with increased reporting of airway symptoms in the general population of northern Sweden. Methods Through a population-based postal survey responded to by 12627 subjects, ages 18–70, living in northern Sweden, the occurrence of airway symptoms was investigated. Cold exposure during work or leisure time was self-reported on numerical rating scales. Binary logistic regression was used to determine the statistical association between cold exposure and airway symptoms. Results For currently working subjects (N = 8740), reporting any occupational cold exposure was associated to wheeze (OR 1.3; 95% CI 1.1–1.4); chronic cough (OR 1.2; 95% CI 1.1–1.4); and productive cough (OR 1.3; 95% CI 1.1–1.4), after adjusting for gender, age, body mass index, daily smoking, asthma, and chronic obstructive pulmonary disease. Leisure-time cold exposure was not significantly associated to reporting airway symptoms. Conclusions Occupational cold exposure was an independent predictor of airway symptoms in northern Sweden. Therefore, a structured risk assessment regarding cold exposure could be considered for inclusion in the Swedish workplace legislation.

scholarly journals Characterizing a two-pronged epidemic in Mexico of non-communicable diseases and SARS-Cov-2: factors associated with increased case-fatality rates

2021 ◽  
Author(s):  
Eric Monterrubio-Flores ◽  
María D Ramírez-Villalobos ◽  
Juan Espinosa-Montero ◽  
Bernardo Hernandez ◽  
Simón Barquera ◽  
...  
Keyword(s):  
Case Fatality ◽  
Logistic Models ◽  
Communicable Diseases ◽  
Chronic Obstructive ◽  
Fatality Rate ◽  
Younger Adults ◽  
Obstructive Pulmonary Disease ◽  
Non Communicable Diseases ◽  
Risk Of Death ◽  
Mexican Adults

Abstract Background People with a previous diagnosis of non-communicable diseases (NCDs) are more likely to develop serious forms of COVID-19 or die. Mexico is the country with the fourth highest fatality rate from SARS-Cov-2, with high mortality in younger adults. Objectives To describe and characterize the association of NCDs with the case-fatality rate (CFR) adjusted by age and sex in Mexican adults with a positive diagnosis for SARS-Cov-2. Methods We studied Mexican adults aged ≥20 years who tested positive for SARS-Cov-2 during the period from 28 February to 31 July 2020. The CFR was calculated and associations with history of NCDs (number of diseases and combinations), severity indicators and type of institution that treated the patient were explored. The relative risk (RR) of death was estimated using Poisson models and CFR was adjusted using logistic models. Results We analysed 406 966 SARS-Cov-2-positive adults. The CFR was 11.2% (13.7% in men and 8.4% in women). The CFR was positively associated with age and number of NCDs (p trend &lt;0.001). The number of NCDs increased the risk of death in younger adults when they presented three or more NCDs compared with those who did not have any NCDs [RR, 46.6; 95% confidence interval (CI), 28.2, 76.9 for women; RR, 16.5; 95% CI, 9.9, 27.3 for men]. Lastly, there was great heterogeneity in the CFR by institution, from 4.6% in private institutions to 18.9% in public institutions. Conclusion In younger adults, higher CFRs were associated with the total number of NCDs and some combinations of type 2 diabetes, chronic kidney disease, chronic obstructive pulmonary disease and cardiovascular disease.

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