scholarly journals Risk factors for recurrent vitreous haemorrhage in patients with proliferative diabetic retinopathy.

2019 ◽  
Author(s):  
Marc BAGET-BERNALDIZ ◽  
Pere Romero-Aroca ◽  
Joaquin Mercado-Gonzalez ◽  
Angel Bautista-Perez ◽  
Núria Soler-Lluís ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Tobacco Consumption ◽  
Vitreous Haemorrhage ◽  
Lower Limbs ◽  
Smoking History ◽  
Diabetic Patients ◽  
Panretinal Photocoagulation ◽  
Systemic Complications ◽  
Urine Albumin

Abstract Background : To investigate which demographic and clinical factors are related to the presence of recurrent vitreous haemorrhage in a population of diabetic patients diagnosed with proliferative diabetic retinopathy [PDR]. Methods: This was a retrospective review-based study. We studied 285 eyes from 165 patients with PDR. We recorded age, gender, type of diabetes mellitus [DM] , type of DM treatment, history of hypertension and body mass index, panretinal photocoagulation status and the presence of concomitant anticoagulant or antiplatelet treatment. We evaluated the mean glycosylated haemoglobin, mean haemoglobin, the urine albumin to creatinine ratio and the estimated glomerular filtration rate in each patient. In addition, we recorded the smoking history [pack-years] and the systemic complications related to DM. We used the logistic regression analysis to study which independent variables were significantly related to the presence of recurrent vitreous haemorrhage. Results: In total, 183 eyes [64%] with PDR had vitreous haemorrhage, of which 68 [37%] underwent recurrent vitreous haemorrhage. In our study, tobacco consumption [OR= 1.21, 95% CI, 1.10- 1.32, P <0.001], duration of diabetes [OR= 1.03, 95% CI, 1.0-1 .07 P = 0.04] and haemoglobin level [OR= -0.24 , 95% CI, -0.16, -0.06 , P <0 .001] had an independently significant associaton with recurrent vitreous haemorrhage. There was a positive correlation between pack-years consumed and the number of vitreous haemorrhages [r=0.339; p<0.001]. In addition, patients with diabetic polineuropathy, myocardial infarction and ischemia in lower limbs had more vitreous haemorrhage events [p<0.001]. Conclusion s : In our study, those patients with PDR who smoked, with longer duration of their diabetes, anaemia and that had previously suffered from cardiovascular events were more prone to suffer from recurrent vitreous haemorrhage.

scholarly journals Risk factors for recurrent vitreous haemorrhage in patients with proliferative diabetic retinopathy.

2019 ◽  
Author(s):  
Marc BAGET-BERNALDIZ ◽  
Pere Romero-Aroca ◽  
Joaquin Mercado-Gonzalez ◽  
Angel Bautista-Perez ◽  
Núria Soler-Lluís ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Tobacco Consumption ◽  
Vitreous Haemorrhage ◽  
Lower Limbs ◽  
Smoking History ◽  
Diabetic Patients ◽  
Panretinal Photocoagulation ◽  
Systemic Complications ◽  
Urine Albumin

Abstract Background : To investigate which demographic and clinical factors are related to the presence of recurrent vitreous haemorrhage in a population of diabetic patients diagnosed with proliferative diabetic retinopathy [PDR]. Methods: This was a retrospective review-based study. We studied 285 eyes from 165 patients with PDR. We recorded age, gender, type of diabetes mellitus [DM] , type of DM treatment, history of hypertension and body mass index, panretinal photocoagulation status and the presence of concomitant anticoagulant or antiplatelet treatment. We evaluated the mean glycosylated haemoglobin, mean haemoglobin, the urine albumin to creatinine ratio and the estimated glomerular filtration rate in each patient. In addition, we recorded the smoking history [pack-years] and the systemic complications related to DM. We used the logistic regression analysis to study which independent variables were significantly related to the presence of recurrent vitreous haemorrhage. Results: In total, 183 eyes [64%] with PDR had vitreous haemorrhage, of which 68 [37%] underwent recurrent vitreous haemorrhage. In our study, tobacco consumption [OR= 1.21, 95% CI, 1.10- 1.32, P <0.001], duration of diabetes [OR= 1.03, 95% CI, 1.0-1 .07 P = 0.04] and haemoglobin level [OR= -0.24 , 95% CI, -0.16, -0.06 , P <0 .001] had an independently significant associaton with recurrent vitreous haemorrhage. There was a positive correlation between pack-years consumed and the number of vitreous haemorrhages [r=0.339; p<0.001]. In addition, patients with diabetic polineuropathy, myocardial infarction and ischemia in lower limbs had more vitreous haemorrhage events [p<0.001]. Conclusion s : In our study, those patients with PDR who smoked, with longer duration of their diabetes, anaemia and that had previously suffered from cardiovascular events were more prone to suffer from recurrent vitreous haemorrhage.

scholarly journals Subfoveal Choroidal Thickness after Panretinal Photocoagulation with Red and Green Laser in Bilateral Proliferative Diabetic Retinopathy Patients: Short Term Results

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Ramak Roohipoor ◽  
Sina Dantism ◽  
Aliasghar Ahmadraji ◽  
Reza Karkhaneh ◽  
Mohammad Zarei ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Nerve Fiber ◽  
Proliferative Diabetic Retinopathy ◽  
Green Laser ◽  
Diabetic Patients ◽  
Panretinal Photocoagulation ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Laser Group

Purpose. To compare subfoveal choroidal, central retinal, and peripapillary nerve fiber layer (RNFL) thickness after panretinal photocoagulation (PRP) with red and green laser in diabetic patients.Study Design. Randomized clinical trial.Methods. A total of 50 patients with bilateral proliferative diabetic retinopathy and no diabetic macular edema underwent PRP. One eye was randomly assigned to red or green laser. Subfoveal choroidal, central retinal, and RNFL thicknesses were evaluated at baseline and 6 weeks after treatment.Results. The mean subfoveal choroidal, central retinal, and peripapillary nerve fiber layer (RNFL) thickness increased significantly in each eye 6 weeks after PRP (Pvalues in red laser group: <0.01, 0.03, and <0.01, resp., and in green laser group <0.01, <0.01, and <0.01). There was no difference between red and green laser considering subfoveal choroidal, central retinal, and peripapillary nerve fiber layer (RNFL) thickness increase after PRP (Pvalues: 0.184, 0.404, and 0.726, resp.).Conclusion. Both red and green lasers increased mean subfoveal choroidal, central retinal, and peripapillary nerve fiber layer (RNFL) thickness significantly 6 weeks after PRP, but there is no difference between these two modalities in this regard.

scholarly journals Intravitreal bevacizumab improves the clearance of vitreous haemorrhage and visual outcomes in patients with proliferative diabetic retinopathy

2019 ◽  
Vol 4 (1) ◽  
pp. e000390 ◽  
Author(s):  
Joonas Wirkkala ◽  
Risto Bloigu ◽  
Nina Maria Hautala
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Average Rate ◽  
Real Life ◽  
Intravitreal Bevacizumab ◽  
Visual Outcome ◽  
Vitreous Haemorrhage ◽  
Panretinal Photocoagulation ◽  
Kaplan Meier ◽  
Real Life Data

ObjectiveTo evaluate the occurrence of vitreous haemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR) and the efficacy of intravitreal bevacizumab (IVB) for VH in 5-year real-life data.Methods and analysis850 adult patients with type 1 (T1D) or type 2 diabetes (T2D) with PDR were screened for VH. The effect of IVB was evaluated by the clearage of VH and the change in best corrected visual acuity (BCVA). The rates of VHs, reinjections, macular oedema, complications, additional treatments and outcomes of spontaneous resorption, panretinal photocoagulation or pars plana vitrectomy (PPV) for VH were also investigated.ResultsVH occurred in 16% of patients with T1D and 9% of patients with T2D with PDR. 336 VHs in 140 eyes of 103 patients were documented. VH was cleared in 92% of cases in less than 3 months by the initial IVB. IVB was superior to other treatment methods in shortening the time for clearance of VH (Kaplan-Meier, p<0.0001). The average rate of IVB reinjections was 1.7±1.1 and the reinjection interval was 7.2±3.9 weeks. BCVA increased 0.73±0.04 logarithm of the minimum angle of resolution units after IVB (generalised estimating equations, p=0.0004). In 5 years, the patients had 2.2±2.7 recurrence of VHs. A simultaneous 72% decrease in the rate of PPVs was documented (p<0.0001).ConclusionVH occurs mostly in patients with T1D. The therapeutic effect of IVB for VH was significant and led to improved clearance of VH and visual outcome. Moreover, IVB prevented persistent and recurrent VHs and decreased the need for costly PPV.

Proteomic Analysis of the Vitreous Body in Proliferative and Non-Proliferative Diabetic Retinopathy

2020 ◽  
Vol 17 ◽  
Author(s):  
Van-An Duong ◽  
Jeeyun Ahn ◽  
Na-Young Han ◽  
Jong-Moon Park ◽  
Jeong-Hun Mok ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Microvascular Complications ◽  
Treatment Options ◽  
Vitreous Body ◽  
Control Group ◽  
Diabetic Patients ◽  
Protein Protein Interaction ◽  
Alpha Beta ◽  
New Treatment

Background: Diabetic Retinopathy (DR), one of the major microvascular complications commonly occurring in diabetic patients, can be classified into Proliferative Diabetic Retinopathy (PDR) and Non-Proliferative Diabetic Retinopathy (NPDR). Currently available therapies are only targeted for later stages of the disease in which some pathologic changes may be irreversible. Thus, there is a need to develop new treatment options for earlier stages of DR through revealing pathological mechanisms of PDR and NPDR. Objective: The purpose of this study was to characterize proteomes of diabetic through quantitative analysis of PDR and NPDR. Methods: Vitreous body was collected from three groups: control (non-diabetes mellitus), NPDR, and PDR. Vitreous proteins were digested to peptide mixtures and analyzed using LC-MS/MS. MaxQuant was used to search against the database and statistical analyses were performed using Perseus. Gene ontology analysis, related-disease identification, and protein-protein interaction were performed using the differential expressed proteins. Results: Twenty proteins were identified as critical in PDR and NPDR. The NPDR group showed different expressions of kininogen-1, serotransferrin, ribonuclease pancreatic, osteopontin, keratin type II cytoskeletal 2 epidermal, and transthyretin. Also, prothrombin, signal transducer and activator of transcription 4, hemoglobin subunit alpha, beta, and delta were particularly up-regulated proteins for PDR group. The up-regulated proteins related to complement and coagulation cascades. Statherin was down-regulated in PDR and NPDR compared with the control group. Transthyretin was the unique protein that increased its abundance in NPDR compared with the PDR and control group. Conclusion: This study confirmed the different expressions of some proteins in PDR and NPDR. Additionally, we revealed uniquely expressed proteins of PDR and NPDR, which would be differential biomarkers: prothrombin, alpha-2-HS-glycoprotein, hemoglobin subunit alpha, beta, and transthyretin.

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