scholarly journals Performance of Diffusion and Perfusion MRI in Evaluating Primary Central Nervous System Lymphomas of Different Locations

2020 ◽  
Author(s):  
Zhen Xing ◽  
Nannan Kang ◽  
Yu Lin ◽  
Xiaofang Zhou ◽  
Zebin Xiao ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
White Matter ◽  
Gray Matter ◽  
Diffusion Coefficients ◽  
Perfusion Mri ◽  
Control Group ◽  
Apparent Diffusion Coefficients ◽  
Apparent Diffusion ◽  
Cortical Gray Matter

Abstract Background: Diffusion and perfusion MRI can invasively define physical properties and angiogenic features of tumors, and guide the individual treatment. The purpose of this study was to investigate whether the diffusion and perfusion MRI parameters of primary central nervous system lymphomas (PCNSLs) are related to the tumor locations.Methods: We retrospectively reviewed the diffusion, perfusion, and conventional MRI of 68 patients with PCNSLs at different locations (group 1: cortical gray matter, group 2: white matter, group 3: deep gray matter). Relative maximum cerebral blood volume (rCBVmax) from perfusion MRI, minimum apparent diffusion coefficients (ADCmin) from DWI of each group were calculated and compared by one-way ANOVA test. In addition, we compared the mean apparent diffusion coefficients (ADCmean) in three different regions of control group.Results: The rCBVmax of PCNSLs yielded the lowest value in the white matter group, and the highest value in the cortical gray matter group (P < 0.001). However, the ADCmin of each subgroup was not statistically different. The ADCmean of each subgroup in control group was not statistically different.Conclusion: Our study confirms that rCBVmax of PCNSLs are related to the tumor location, and provide simple but effective information for guiding the clinical practice of PCNSLs.

scholarly journals Performance of Diffusion and Perfusion MRI in Evaluating Primary Central Nervous System Lymphomas of Different Locations

2020 ◽  
Author(s):  
Zhen Xing ◽  
Nannan Kang ◽  
Yu Lin ◽  
Xiaofang Zhou ◽  
Zebin Xiao ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
White Matter ◽  
Gray Matter ◽  
Cerebral Blood Volume ◽  
Tumor Location ◽  
Perfusion Mri ◽  
Individual Treatment ◽  
Apparent Diffusion Coefficients ◽  
Cortical Gray Matter

Abstract BACKGROUND AND PURPOSE Diffusion and perfusion MRI can invasively define physical properties and angiogenic features of tumors, and guide the individual treatment. The purpose of this study was to investigate whether the diffusion and perfusion MRI parameters of primary central nervous system lymphomas (PCNSLs) are related to the tumor locations.MATERIALS AND METHODS We retrospectively reviewed the diffusion, perfusion, and conventional MRI of 68 patients with PCNSLs at different locations (group 1: cortical gray matter, group 2: white matter, group 3: deep gray matter). Relative maximum cerebral blood volume (rCBV max ) from perfusion MRI, minimum apparent diffusion coefficients (ADC min ) from DWI of each group were calculated and compared by one-way ANOVA test.RESULTS The rCBV max of PCNSLs yielded the lowest value in the white matter group, and the highest value in the cortical gray matter group ( P <0.001). However, the ADC min of each subgroup was not statistically different.CONCLUSIONS Our study confirms that rCBV max of PCNSLs are related to the tumor location, and provide simple but effective information for guiding clinical practice of PCNSLs.

Tissue Factor Localization in Non-Human Primate Cerebral Tissue

1992 ◽  
Vol 68 (06) ◽  
pp. 642-647 ◽  
Author(s):  
Gregory J del Zoppo ◽  
Jian-Qing Yu ◽  
Brian R Copeland ◽  
Winston S Thomas ◽  
Jacob Schneiderman ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
White Matter ◽  
Basal Ganglia ◽  
Tissue Factor ◽  
Gray Matter ◽  
Sandwich Elisa ◽  
Procoagulant Activity ◽  
Cortical Gray Matter ◽  
Human Primate

SummaryTissue factor (TF), the principal procoagulant of human brain, resides in specific regions of the non-human primate central nervous system. Immunohistochemical studies employing murine anti-human TF monoclonal antibodies (MoAbs) detected TF antigen in the cortex, basal ganglia, cerebellum, and cervical spinal cord in three normal baboon subjects. Although significantly less prominent than human cortical gray matter, a distinct partition of TF in gray matter >white matter was noted. The gray matter predilection of TF was confirmed in primate temporal and parietal lobe cortex by both sandwich ELISA and one-stage coagulation assay. Variation in the relative quantity of TF antigen was observed by ELISA among the three subjects studied. Procoagulant activity followed the pattern of TF antigen (cortical gray matter >basal ganglia ≥cerebellum >cortical white matter), and was 96.5–98.5% inhibitable by a function inhibiting anti-human TF MoAb combination. TF antigen was associated with the microvasculature of all cerebral tissues studied, and spared capillaries most selectively in the cerebral cortex, basal ganglia, and cerebellum. These findings suggest a highly specific ordering of TF antigen and related procoagulant activity in the central nervous system of the baboon, confined primarily to gray matter parenchyma, and to the non-capillary microvasculature.

scholarly journals Decreased Asialotransferrin in Cerebrospinal Fluid of Patients with Childhood-Onset Ataxia and Central Nervous System Hypomyelination/Vanishing White Matter Disease

2005 ◽  
Vol 51 (11) ◽  
pp. 2031-2042 ◽  
Author(s):  
Adeline Vanderver ◽  
Raphael Schiffmann ◽  
Margaret Timmons ◽  
Katherine A Kellersberger ◽  
Dan Fabris ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
White Matter ◽  
Control Group ◽  
White Matter Disease ◽  
Childhood Onset ◽  
Vanishing White Matter Disease ◽  
Vanishing White Matter

Abstract Background: A biomarker for the diagnosis of childhood-onset ataxia and central nervous system hypomyelination (CACH)/vanishing white matter disease (VWM) would have clinical utility and pathophysiologic significance. Methods: We used 2-dimensional gel electrophoresis/mass spectrometry to compare the cerebrospinal fluid proteome of patients with mutation-confirmed CACH/VWM with that of unaffected controls. We characterized selected spots by in-gel digestion, matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry, and nanospray Fourier transform mass spectrometry. Results: A specific transferrin spot pattern was detected in the CSF samples of the CACH/VWM group (n = 7), distinguishing them from the control group (n = 23) and revealing that patients with CACH/VWM have a deficiency of the asialo form of transferrin usually present in healthy cerebrospinal fluid. The glycopeptide structure, determined from isolated transferrin spots by use of in-gel digestion and extraction, was found to be consistent with earlier reports. Conclusions: The transferrin isoform abnormality in the cerebrospinal fluid of patients with CACH/VWM appears unique and is a potential clinical diagnostic biomarker. The rapid, efficient diagnosis of this disorder would have a significant impact on clinical studies exploring new strategies for the management and treatment of this disease.

scholarly journals An Attenuated Variant of the GDVII Strain of Theiler’s Virus Does Not Persist and Does Not Infect the White Matter of the Central Nervous System

1999 ◽  
Vol 73 (1) ◽  
pp. 801-804 ◽  
Author(s):  
Nadine Jarousse ◽  
Ekaterina G. Viktorova ◽  
Evgeny V. Pilipenko ◽  
Vadim I. Agol ◽  
Michel Brahic
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
White Matter ◽  
Gray Matter ◽  
Noncoding Region ◽  
Theiler's Virus ◽  
Recombinant Viruses ◽  
Central Nervous Systems ◽  
The Central Nervous System

ABSTRACT The DA strain of Theiler’s virus causes a persistent and demyelinating infection of the white matter of spinal cord, whereas the GDVII strain causes a fatal gray-matter encephalomyelitis. Studies with recombinant viruses showed that this difference in phenotype is controlled mainly by the capsid. However, conflicting results regarding the existence of determinants of persistence in the capsid of the GDVII strain have been published. Here we show that a GDVII virus whose neurovirulence has been attenuated by an insertion in the 5′ noncoding region does not persist in the central nervous systems of mice. Furthermore, this virus infects the gray matter efficiently, but not the white matter. These results confirm the absence of determinants of persistence in the GDVII capsid. They suggest that the DA capsid controls persistence by allowing the virus to infect cells in the white matter of the spinal cord.

scholarly journals Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T

2011 ◽  
Vol 67 (5) ◽  
pp. 1203-1209 ◽  
Author(s):  
Hermien E. Kan ◽  
Aranee Techawiboonwong ◽  
Matthias J. P. van Osch ◽  
Maarten J. Versluis ◽  
Dinesh K. Deelchand ◽  
...  
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Diffusion Coefficients ◽  
Brain Metabolites ◽  
Apparent Diffusion Coefficients ◽  
Apparent Diffusion
Sign in / Sign up

Export Citation Format

Share Document