scholarly journals Accuracy of Different Metabolic Syndrome Definitions for Detecting Increased Carotid Intima-media Thickness in Peruvian Type 2 Diabetes Mellitus Subjects without Cardiovascular Disease.

2020 ◽  
Author(s):  
Alberto Teruya-Gibu ◽  
Marlon Yovera-Aldana ◽  
Diana Urquiza-Salvador ◽  
Laurie Marcilla-Trullenque
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional ◽  
Media Thickness ◽  
Bilateral Carotid

Abstract Backrgound: To estimate the accuracy of metabolic syndrome definitions for detecting Carotid Intima-Media thickness (CIMT) in Peruvian type 2 diabetes mellitus (T2DM) subjects without cardiovascular events.Methods: We performed a cross-sectional evaluation of T2DM subjects from the endocrinology service of two reference health centers without stroke or coronary disease. . Bilateral carotid intima-media thickness was measure by B mode ultrasound one only operator. We performed four definitions of Metabolic Syndrome; 1. Cholesterol Education Program Adult Treatment Panel III (ATP III), 2. Harmonized criteria; 3. Gurka's Metabolic syndrome severity score (MSSS) formula. 4. Non-glucose modified MSSS. We calculated the area under the receiver operator curve (AUROC) for detecting increased CIMT (≥ 0.86 mm) between metabolic syndrome definitions. Results: We included 184 subjects with T2DM, 29% were men with a mean age of 61.5 ± 10.5 years old. Median diabetes time was 10.8 years (IQR 4.8 to 19.4), and 26.8% achieved HbA1c goals. Non-glucose modified MSSS was the only definition significantly correlated with elevated CIMT (r = 0.19; p<0.01), and it showed the best accuracy for predicting elevated CIMT (AUC: 0.61, CI95%: 0.52-0.70). Adjusting for age, sex, and HbA1c, each point increase in the non-glucose MSSS Z score, the risk of altered CIMT increases by 59% RP 1.59 (CI 95% 1.09 - 2.35; p=0.017). Conclusions: Non-glucose modified MSSS had a weak accuracy for elevated CIMT and was the best compared to ATP III, harmonized, and original MSSS. Further research on no MS-factors is required to predict better elevated CIMT.

scholarly journals Pengaruh Simvastatin Terhadap Ketebalan Intima-Media Karotis Pada Pasien Stroke Iskemik Dengan Diabetes Mellitus Tipe 2

2019 ◽  
Vol 6 (1) ◽  
pp. 20-23
Author(s):  
Aditya Kurnianto ◽  
Dodik Tugaswowo Pramukarso
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ischemic Stroke ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
T Test ◽  
Stroke Patients ◽  
Media Thickness

BACKGROUND :Ischemic stroke is the most common stroke comprising 70-80% of all cases. Carotid intima-media thickness (CIMT) is associated with the occurrence of stroke in older age and adults. Patients with type 2 diabetes mellitus tend to develop a thickening of intima-media carotid artery. Simvastatins inhibit further atherothrombotic process. OBJECTIVE : To analyze the effect of simvastatin for CIMT in ischemic stroke patient with type 2 diabetes mellitus. METHOD : This study was a Randomized Pretest-Posttest Design and conducted at the Hospital Inpatient Ward Dr. Kariadi and Ketileng Semarang from January to December 2014 for all first ischemic stroke patients with Type 2 Diabetes Mellitus. Subjects were divided into groups of 26 controls and 28 patients treated groups. Treatment group were given simvastatin 20 mg each daily for 24 weeks in 28 subjects with a history of acute ischemic stroke and type 2 Diabetes mellitus. Examine the CIMT at the 1st week and 24th week. The normality of the data were tested using Shapiro Wilk and the differences analyzed by using Paired t-test and independent t test. RESULT : There was a significant differences between delta carotid intima-media thickness on administration of simvastatin for ischemic stroke patients with type 2 diabetes mellitus (p=0,008). CONCLUSION : Simvastatin significantly decreases CIMT on ischemic stroke patients with type 2 diabetes mellitus. Keyword : simvastatin, ischemic stroke, carotid intima-media thickness, type 2 diabetes mellitus   LATAR BELAKANG :Stroke iskemik memiliki angka insidensi terbanyak yaitu 70-80% kasus stroke. Ketebalan Intima-media karotis berhubungan dengan terjadinyastroke pada usia tua.Pasien dengan Diabetes mellitus tipe 2 memiliki kemungkinan yang lebih besar mengalami penebalan intima-media carotis. Simvatatin menghambat proses aterotrombosis. TUJUAN :Untuk menganalisis pengaruh simvastatin terhadap ketebalan intima-media karotis pada pasien stroke iskemik dengan diabetes mellitus tipe 2. METODE :Penelitian ini adalah dengan Randomized Pretest-Posttest Design dan telah dilakukan di Rawat Jalan RSUP dr. Kariadi dan poli saraf rawat jalan RSUD Kota Semarang mulai Januari sampai dengan Desember 2014 untuk semua pasien stroke iskemik pertama kali dengan diabetes mellitus tipe 2. Subjek dibagi menjadi kelompok kontrol 26 pasien dan kelompok perlakuan 28 pasien. Kelompok perlakuan diberi simvastatin 20 mg sehari selama 24 minggu pada 28 subjek stroke iskemik dengan  diabetes mellitus tipe 2. Pemeriksaan ketebalan intima-media karotis dilakukan pada minggu ke-1 dan minggu ke-24. Data kemudian di uji normalitasnya menggunakan Saphiro wilk, lalu di analisis menggunakan uji beda paired t testdan independent t test. HASIL :  Kelompok perlakuan didapatkan penurunan ketebalan tunika intima arteri karotis (0,395 + 0,46; p=0,514), KESIMPULAN : Pemberian simvastatin menurunkan ketebalan intima-media karotis secara bermakna pada pasien stroke iskemik dengan diabetes mellitus tipe 2. Kata Kunci     :simvastatin,stroke iskemik, ketebalan intima-media karotis, diabetes mellitus tipe 2      

scholarly journals Relation of Epicardial Fat Thickness with Carotid Intima-Media Thickness in Patients with Type 2 Diabetes Mellitus

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Mustafa Cetin ◽  
Musa Cakici ◽  
Mustafa Polat ◽  
Arif Suner ◽  
Cemil Zencir ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Waist Circumference ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Epicardial Fat Thickness ◽  
Media Thickness ◽  
Fat Thickness

Aims.The aim of this study was to investigate the relationship of echocardiographic epicardial fat thickness (EFT) with carotid intima-media thickness (CIMT), in patients with type 2 diabetes mellitus (T2DM).Methods and Results.A total of 139 patients with T2DM (mean age 54.3 ± 9.2 and 49.6% male) and 40 age and sex-matched control subjects were evaluated. Echocardiographic EFT and ultrasonographic CIMT were measured in all subjects. Patients with T2DM had significantly increased EFT and CIMT than those of the controls (6.0 ± 1.5 mm versus 4.42 ± 1.0 mm,P<0.001and 0.76 ± 0.17 mm versus 0.57 ± 0.14 mm,P<0.001, resp.). EFT was correlated with CIMT, waist circumference, BMI, age, duration of T2DM, HbA1c in the type 2 diabetic patients. Linear regression analysis showed that CIMT (β=3.52,t=3.72,P<0.001) and waist circumference (β=0.36,t=2.26,P=0.03) were found to be independent predictors of EFT. A cutoff high risk EFT value of 6.3 mm showed a sensitivity and specificity of 72.5% and 71.7%, respectively, for the prediction of subclinical atherosclerosis.Conclusion.We found that echocardiographic EFT was significantly higher in patients with T2DM. Our study also showed that EFT was strongly correlated with waist circumference and CIMT as being independent of sex.

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