Predictors of Hearing Functional Outcome following Surgery for Cerebellopontine Angle Meningioma.

Abstract OBJECTIVE Cerebellopontine angle (CPA) meningioma can affect hearing function and require expeditious treatment to prevent permanent hearing loss. The authors sought to determine the factors associated with hearing functional outcome in CPA meningioma patients treated with surgery and/or radiation therapy either stereotactic radiosurgery or stereotactic radiation therapy. METHODS Consecutive patients with CPA meningioma who had presented at our hospital from 2008 to 2018 were identified through retrospective chart review. Hearing function-pure tone audiogram (PTA) and speech discrimination score (SDS)-was assessed before and after surgery for CPA meningioma. Hearing function with PTA>50 dB and SDS<69% were defined as poor hearing functional outcome. Multivariable Cox Proportional Hazards Regression model was used to assess the associations between pre-operative hearing functional assessment and post-operative hearing functional outcomes. RESULTS The study cohort included 31 patients (80.6% females, with a mean age of 61.3±15.2 years) with a median clinical follow-up of 5 months (range, 1 week-98 months). The mean pre-operative PTA and SDS were 23.8±11.2 dB and 64.4±22.2% respectively. At the last visit, there was a significant hearing recovery, with an improvement of 29.7±18.0 dB (p<0.001) and 87.6±17.8% (p<0.001) in PTA and SDS respectively. Multivariable cox proportional hazards regression model was conducted after adjusting for age, gender, tumor volume, location, and classification of the tumor, which revealed that patients undergoing surgery through retro sigmoid approach [Hazards Ratio (HR): 32.1, 95% Confidence Interval (CI): 2.11-491.0, p=0.01] and gross total resection (GTR) (HR: 2.99, 95%CI: 1.09-9.32, p=0.05) had significantly higher risk of poor hearing functional outcome. Moreover, patients with poor preoperative hearing had 85% higher chances of poor hearing functional outcome post operatively (HR: 0.15, 95%CI: 0.03-0.59, p=0.007). CONCLUSION Postoperative improvement in hearing is a reasonable expectation following surgery for CPA meningioma. Preoperative hearing, surgical approach and extent of surgical resection are predictive of postoperative hearing function outcome and can identify patients at higher risk of hearing loss.

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Testing for Covariate Effect in the Cox Proportional Hazards Regression Model

Communication in Statistics- Theory and Methods ◽

10.1080/03610920802536958 ◽

2009 ◽

Vol 38 (14) ◽

pp. 2333-2347 ◽

Cited By ~ 6

Author(s):

Karthik Devarajan ◽

Nader Ebrahimi

Keyword(s):

Regression Model ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Covariate Effect ◽

Cox Proportional Hazards Regression ◽

Proportional Hazards Regression

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MODELLING THE DETERMINANTS OF UNDER-FIVE CHILD MORTALITY RATES USING COX PROPORTIONAL HAZARDS REGRESSION MODEL

FUDMA Journal of Sciences ◽

10.33003/fjs-2020-0404-496 ◽

2021 ◽

Vol 4 (4) ◽

pp. 401-408

Author(s):

M. C. Musa ◽

O. E. Asiribo ◽

H. G. Dikko ◽

M. Usman ◽

S. S. Sani

Keyword(s):

Regression Model ◽

Child Mortality ◽

Proportional Hazards ◽

Mortality Rates ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model ◽

Predictor Variables ◽

Under Five ◽

Cox Proportional Hazards Regression ◽

Proportional Hazards Regression

An under-five childhood mortality rates in Nigeria is still high, despite efforts of government at all levels to combat the menace. This study examined some factors that significantly affect under-five child mortality. A sample of mothers with children under the age of five from Nigeria Demographic and Health Survey data (NDHS, 2013 & 2018) was used to assess the effect of some selected predictor variables (or covariates) on childhood survival. Cox proportional hazards model is essentially a regression model popularly used for investigating the association between the survival time and one or more predictor variables. The results from final fitted Cox proportional hazards regression model that the covariates, contraceptive used by the mother, state of residence, birth weight of child and type of toilet facility used by the h-ousehold were found to be significantly associated with under-five survival in the North Central Region of Nigeria. All the calculations are performed using the R software for statistical analysis.

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Prognostic Significance of Serum Free Amino Acids in Head and Neck Cancers

Cells ◽

10.3390/cells8050428 ◽

2019 ◽

Vol 8 (5) ◽

pp. 428 ◽

Cited By ~ 3

Author(s):

Vit Vsiansky ◽

Marketa Svobodova ◽

Jaromir Gumulec ◽

Natalia Cernei ◽

Dagmar Sterbova ◽

...

Keyword(s):

Amino Acids ◽

Amino Acid ◽

Regression Model ◽

Head And Neck ◽

Cell Lines ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Transformed Cells ◽

Cox Proportional Hazards Regression ◽

Proportional Hazards Regression

Despite distinctive advances in the field of head and neck squamous cell cancer (HNSCC) biomarker discovery, the spectrum of clinically useful prognostic serum biomarkers is limited. As metabolic activities in highly proliferative transformed cells are fundamentally different from those in non-transformed cells, specific shifts in concentration of different metabolites may serve as diagnostic or prognostic markers. Blood amino acids have been identified as promising biomarkers in different cancers before, but little is known about this field in HNSCC. Blood amino acid profiles of 140 HNSCC patients were examined using high-performance liquid chromatography. Cox proportional hazards regression model was used to assess the prognostic value of amino acid concentrations in serum. Colony forming assay was used to identify the effect of amino acids that were significant in Cox proportional hazards regression models on colony forming ability of FaDu and Detroit 562 cell lines. In the multivariable Cox regression model for overall survival (OS), palliative treatment was associated with an unfavourable prognosis while high serum levels of methionine have had a positive prognostic impact. In the relapse-free survival (RFS) multivariable model, methionine was similarly identified as a positive prognostic factor, along with tumor localization in the oropharynx. Oral cavity localization and primary radio(chemo)therapy treatment strategy have been linked to poorer RFS. 1mM serine was shown to support the forming of colonies in both tested HNSCC cell lines. Effect of methionine was exactly the opposite.

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