scholarly journals The Effect of Acellular Dermal Matrix on the Success of Primary Palatoplasty With Intravelar Veloplasty

2021 ◽  
Author(s):  
Hossein Abdali ◽  
Mohammad Ali Hoghooghi ◽  
Shirin Fattahpour ◽  
Fatemeh Derakhshandeh ◽  
Farnoosh Mohtashampour ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Acellular Dermal Matrix ◽  
Fistula Formation ◽  
Control Group ◽  
Dermal Matrix ◽  
Surgical Infection ◽  
And Control ◽  
Acellular Dermal ◽  
Positive Results ◽  
Intravelar Veloplasty

Abstract BackgroundAcellular Dermal Matrix graft is usually used to repair fistulas following a cleft palate and has had positive results. But its use for primary palatoplasty has been less studied. Our aim was to compare the usefulness of using Acellular Dermal Matrix transplantation for primary palatoplasty with intravelar veloplasty in contrast to its lack of useMaterials and methodsA total of 72 children (6 months to 6 years old) with cleft palate were included in the study. The case-control prospective observations were conducted. A group underwent primary palatoplasty with intravelar veloplasty using Acellular Dermal Matrix and the control group had the same surgery without using Acellular Dermal Matrix. Patients were monitored for fistula formation, post-operative infection, and ulcers.ResultsNo post-surgical infection and wound opening was seen in any group. In the recipients of Acellular Dermal Matrix and control group three and six fistula was reported in which patients had soft and hard palate involvement and the cleft with length greater than 15 mm.ConclusionsConsidering the double incidence of fistulas in the control group compared to the ADM recipient, it seems that the use of ADM can be effective in reducing the incidence of fistulas. Since fistula is one of the complications of primary palatoplasty surgery and leads to secondary surgeries, the use of ADM can be helpful.

Primary Palatoplasty With Intravelar Veloplasty Using Acellular Dermal Matrix Interpositional Graft

2020 ◽  
Vol 32 (1) ◽  
pp. 252-256
Author(s):  
Chang Ryul Yi ◽  
Dong-Nyeok Jeon ◽  
Jong-Woo Choi ◽  
Tae Suk Oh
Keyword(s):  
Acellular Dermal Matrix ◽  
Dermal Matrix ◽  
Acellular Dermal ◽  
Intravelar Veloplasty

scholarly journals Acellular dermal matrix allograft: An effective adjunct to oronasal fistula repair in patients with cleft palate

2014 ◽  
Vol 4 (2) ◽  
pp. 158 ◽  
Author(s):  
MosaadAbd Al Jawwad Khalifah ◽  
SalahAbdelfattah Metwally ◽  
KhaledAbd Elmonaem Abd ElKader ◽  
MarwaAbdElWahhab El-Kassaby
Keyword(s):  
Cleft Palate ◽  
Acellular Dermal Matrix ◽  
Fistula Repair ◽  
Dermal Matrix ◽  
Oronasal Fistula ◽  
Acellular Dermal ◽  
Effective Adjunct

Use of Acellular Dermal Matrix Combined with a Component Separation Technique for Repair of Contaminated Large Ventral Hernias: A Possible Ideal Solution for this Clinical Challenge

2015 ◽  
Vol 81 (2) ◽  
pp. 150-156 ◽  
Author(s):  
Fei Yang ◽  
Li Ji-Ye ◽  
Li Rong ◽  
Tian Wen
Keyword(s):  
Acellular Dermal Matrix ◽  
Component Separation ◽  
Separation Technique ◽  
Oblique Muscle ◽  
Dermal Matrix ◽  
Surgical Infection ◽  
Wound Debridement ◽  
Component Separation Technique ◽  
Acellular Dermal ◽  
Ventral Hernias

Repair of large contaminated ventral hernias is always challenging because of massive loss of muscular and fascial tissues, high risk of surgical infection and recurrence, and contraindication to use of a permanent prosthesis. This study reviewed retrospectively data of 35 patients with contaminated large ventral hernias who received repair using acellular dermal matrix combined with a component separation technique from 2009 to 2011. Twenty-one males and 14 females were identified with a mean age of 45.5 ± 12.5 years and a mean body mass index of 22.5 ± 5.8 kg/m2. Simultaneously, nine patients underwent bowel fistula resection, 13 patients underwent ostomy takedown, five patients underwent recurrent colon cancer dissection, and eight patients underwent infectious permanent mesh removal and wound débridement. Mean defect size was 125.0 ± 23.5 cm2. The aponeurosis of the external oblique muscle was transected and separated from internal oblique muscle to reach abdominal closure. A cellular dermal matrix was placed in an onlay fashion and mean mesh size was 300.0 ± 65.0 cm2. Thirty-five patients had a mean follow-up period of 36.5 ± 12.5 months. Wound bleeding and partial dehiscence occurred at 36 hours post-operatively. Five patients reported abdominal wall pain during the first postoperative month. Five patients developed surgical site infection. Four patients were detected to develop seroma with volume more than 20 mL by B-ultrasound examination. No recurrence and chronic foreign body sensation were followed up. Use of acellular dermal matrix combined with a component separation technique is safe and efficient management for repair of contaminated large ventral hernia, in which permanent prosthesis placement is contraindicated.

Repair of Primary Cleft Palate and Oronasal Fistula With Acellular Dermal Matrix: A Systematic Review and Surgeon Survey

2018 ◽  
Vol 56 (2) ◽  
pp. 187-195 ◽  
Author(s):  
Andrew Simpson ◽  
Osama A. Samargandi ◽  
Alison Wong ◽  
M. Elise Graham ◽  
Michael Bezuhly
Keyword(s):  
Systematic Review ◽  
Cleft Palate ◽  
Online Survey ◽  
Acellular Dermal Matrix ◽  
Controlled Trials ◽  
Dermal Matrix ◽  
Oronasal Fistula ◽  
Current Trends ◽  
Palate Repair ◽  
Acellular Dermal

Objective: The current review and survey aim to assess the effectiveness of acellular dermal matrix (ADM) in the repair of cleft palate and oronasal fistula and to evaluate the current trends of ADM use in palate surgery. Design: A systematic review of English articles was conducted using MEDLINE (1960 to July 1, 2016), the Cochrane Controlled Trials Register (1960 to July 1, 2016), and EMBASE (1991 to July 1, 2016). Additional studies were identified through a review of references cited in initially identified articles. Search terms included “cleft palate,” “palatal,” “oronasal fistula,” “acellular dermal matrix,” and “Alloderm®.” An online survey was disseminated to members of the American Cleft Palate-Craniofacial Association to assess current trends in ADM use in palate surgery. Study Selection: All studies evaluating the outcome of primary palate repair or repair of oronasal fistula with the use of aceullar dermal matrix products were included in the review. Results: Twelve studies met inclusion criteria for review. Studies were generally of low quality, as indicated by methodological index for non-randomized studies (MINORS) scores ranging from 7 to 14. The pooled estimate for fistula formation after primary palatoplasty following ADM use was 7.1%. The pooled estimate for recurrence of fistula after attempted repair using ADM was 11%. Thirty-six cleft surgeons responded to the online survey study. Of these, 45% used ADM in primary cleft palate repair, while 67% used ADM for repair of oronasal fistulae. Conclusion: Use of ADM products is commonplace in palate surgery. Despite this, there is a paucity of high-quality data demonstrating benefit. Further randomized controlled trials examining ADM in palate surgery are required to help develop structured guidelines and improve care.

The Use of Acellular Dermal Matrix in Combination With Pedicled Buccal Fat Pad in Wide Cleft Palate Repair: A Case Report and Literature Review

2019 ◽  
Vol 56 (10) ◽  
pp. 1381-1385
Author(s):  
Benjamin K. L. Goh ◽  
Hui-Ling Chia
Keyword(s):  
Cleft Palate ◽  
Acellular Dermal Matrix ◽  
Patch Repair ◽  
Fat Pad ◽  
Buccal Fat Pad ◽  
Dermal Matrix ◽  
Cleft Palate Repair ◽  
Palate Repair ◽  
Free Closure ◽  
Acellular Dermal

We describe a case of the combined use of acellular dermal matrix and pedicled buccal fat pad (BFP) in a wide U-shaped cleft palate repair. Acellular dermal matrix was used as a “patch” repair for the nasal mucosa defect as opposed to the conventional inlay graft. The advantages include reduced cost and a smaller avascular graft load. Lateral relaxing incisions were made to ensure tension-free closure of oromucosa at midline. Lateral oromucosa defect closure with well-vascularized pedicled BFP ensures enhanced healing, less palatal contracture and shortening, and reduced infection. The palate healed with mucosalization at 2 weeks, and no complications were noted at 6 months follow-up.

Acellular dermal matrix contributes to epithelialization in patients with chronic sinusitis

2019 ◽  
Vol 33 (8) ◽  
pp. 1053-1059
Author(s):  
Zhong Bing ◽  
Liu Feng ◽  
Chun-Shu Wu ◽  
Jin-Tao Du ◽  
Ya-Feng Liu ◽  
...  
Keyword(s):  
Chronic Sinusitis ◽  
Acellular Dermal Matrix ◽  
Gelatin Sponge ◽  
Matrix Group ◽  
Control Group ◽  
Nasal Surgery ◽  
Dermal Matrix ◽  
Mucosal Repair ◽  
Matrix Groups ◽  
Acellular Dermal

Background Nasal endoscopic surgery is widely used for nasal diseases, including sinusitis and tumors. However, scar hyperplasia, nasal irritation, scab, and nasal obstruction delay nasal mucosal recovery, with prolonged cleaning exacerbating the patient's financial burden. Here, we presented a novel approach for the treatment of nasal mucosal defects, termed acellular dermal matrix. Methods A total of 31 patients with bilateral chronic sinusitis (maxillary sinusitis and ethmoid sinusitis) underwent nasal surgery and nasal mucosal repair in September–October 2016. We divided the nasal cavities of each patient into control and acellular dermal matrix groups, randomly selected one side for nasal mucosal repair by surgery. A suitable acellular dermal matrix size was selected according to the defect in each patient. After pruning, the acellular dermal matrix was placed on the wound surface and filled with gelatin sponge. All patients were followed up for 14 weeks to compare nasal mucosal epithelialization between the control and acellular dermal matrix groups. Results：No obvious complications and adverse reactions were observed after nasal surgery. Lund-Kennedy scores in the acellular dermal matrix group were significantly decreased compared with the control group at 8 (0 (0, 1) vs. 2 (2, 4); P<0.05) weeks. Epithelialization time of eight weeks in the acellular dermal matrix groups was significantly decreased than the control group of 14 weeks. Conclusion Acellular dermal matrix provides a growth framework for the healthy mucosa on the wounded surface and reduces postoperative epithelialization time.

scholarly journals Evaluation of lymphangiogenesis in acellular dermal matrix

2014 ◽  
Vol 47 (03) ◽  
pp. 318-324 ◽  
Author(s):  
Mario Cherubino ◽  
Igor Pellegatta ◽  
Federico Tamborini ◽  
Michele Cerati ◽  
Fausto Sessa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Endothelial Cells ◽  
Cell Invasion ◽  
Acellular Dermal Matrix ◽  
Wound Contraction ◽  
Control Group ◽  
Dermal Substitute ◽  
Dermal Matrix ◽  
Microscopic Evaluation ◽  
Acellular Dermal

ABSTRACT Introduction: Much attention has been directed towards understanding the phenomena of angiogenesis and lymphangiogenesis in wound healing. Thanks to the manifold dermal substitute available nowadays, wound treatment has improved greatly. Many studies have been published about angiogenesis and cell invasion in INTEGRA®. On the other hand, the development of the lymphatic network in acellular dermal matrix (ADM) is a more obscure matter. In this article, we aim to characterize the different phases of host cell invasion in ADM. Special attention was given to lymphangiogenic aspects. Materials and Methods: Among 57 rats selected to analyse the role of ADM in lymphangiogenesis, we created four groups. We performed an excision procedure on both thighs of these rats: On the left one we did not perform any action except repairing the borders of the wound; while on the right one we used INTEGRA® implant. The excision biopsy was performed at four different times: First group after 7 days, second after 14 days, third after 21 days and fourth after 28 days. For our microscopic evaluation, we used the classical staining technique of haematoxylin and eosin and a semi-quantitative method in order to evaluate cellularity counts. To assess angiogenesis and lymphangiogenesis development we employed PROX-1 Ab and CD31/PECAM for immunohistochemical analysis. Results: We found remarkable wound contraction in defects that healed by secondary intention while minor wound contraction was observed in defects treated with ADM. At day 7, optical microscopy revealed a more plentiful cellularity in the granulation tissue compared with the dermal regeneration matrix. The immunohistochemical process highlighted vascular and lymphatic cells in both groups. After 14 days a high grade of fibrosis was noticeable in the non-treated group. At day 21, both lymphatic and vascular endothelial cells were better developed in the group with a dermal matrix application. At day 28, lymphatic endothelial cells had organized themselves, engineering the pseudocylindrical structure better disposed in the ADM group than in the control group, and the lymphatic cells were detectable inside the vessels’ lumen in this group. Conclusion: This study has made it possible to demonstrate the absolute importance of an ADM in proper wound healing and has shown better definition of both the qualitative and quantitative aspects of lymphangiogenesis compared to the second intention healing. A major grade of organization of the extracellular matrix and a minor grade of fibrosclerosis in ADM allowed a well-structured morphologic and functional development of the endothelial and lymphatic vascular structures. This study hopes to represent a clinical basis for a wider use of ADM in lesions where lymphatic complications are common.

scholarly journals The Utility of Novel Fish-Skin Derived Acellular Dermal Matrix (Kerecis) as a Wound Dressing Material

2021 ◽  
Vol 17 (1) ◽  
pp. 39-47
Author(s):  
Tae Hyung Kim ◽  
Jun Ho Park ◽  
Hyun Gyo Jeong ◽  
Syeo Young Wee
Keyword(s):  
Wound Healing ◽  
Healing Rate ◽  
Computer Software ◽  
Acellular Dermal Matrix ◽  
Control Group ◽  
Omega 3 ◽  
Dermal Matrix ◽  
Burn Wounds ◽  
Novel Material ◽  
Acellular Dermal

Background: The newly-approved Kerecis is a piscine acellular dermal xenograft. This piscine acellular dermal matrix (ADM) has specific bioactive lipid mediators, omega-3 polyunsaturated fatty acids, and has a positive effect on the process of wound healing. This study aimed to explore the utility of this novel material by comparing healing rates, and suggest the proper timing for applying Kerecis.<br/>Methods: Patients who visited the hospital with acute or chronic deep dermal wounds from June 2019 to May 2020 were enrolled in the study. A total of 48 patients were assessed. All wounds in the experimental group (n=16) were treated only once with Kerecis and a non-adherent absorptive foam material (Therasorb) to cover the ADM. In the control group, daily conventional dressings were provided. All wounds sizes were measured with mass-market computer software in a method suggested by the authors for the first time.<br/>Results: The mean healing rate proved to be faster in the Kerecis group (P<0.05) versus the control group, and no complications were observed. It was statistically proved that treating burn wounds with the ADM showed better healing rates than the conventional method (P<0.05).<br/>Conclusion: This study establishes that managing wounds with the ADM is likely to heal wounds faster than traditional dressings. In addition, for burn wounds, a prolonged application (10 days vs. 5 days after the onset) showed a better wound healing rate (98.8%±2.5% vs. 67.0%±14.3%, respectively, P=0.029).

scholarly journals Cleft Palate Fistula Closure Utilizing Acellular Dermal Matrix

2018 ◽  
Vol 6 (3) ◽  
pp. e1682 ◽  
Author(s):  
Omri Emodi ◽  
Jiriys George Ginini ◽  
John A. van Aalst ◽  
Dekel Shilo ◽  
Raja Naddaf ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Acellular Dermal Matrix ◽  
Fistula Closure ◽  
Dermal Matrix ◽  
Acellular Dermal
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