scholarly journals Epidemiology and Clinical Features of Anterior Uveitis: a Prospective Study

2022 ◽  
Author(s):  
Wei-Yu Chiang ◽  
Shih-Chou Chen ◽  
Shwu-Jiuan Sheu ◽  
Hsi-Kung Kuo
Keyword(s):  
Prospective Study ◽  
Clinical Features ◽  
Anterior Uveitis ◽  
Laboratory Data ◽  
Case Series ◽  
Older Age ◽  
Hla B27 ◽  
Clinical Diagnoses ◽  
Southern Taiwan ◽  
Posterior Synechiae

Abstract Purpose: To report the pattern, epidemiology, and clinical features of anterior uveitis (AU) in southern TaiwanMethods: A prospective case series was performed to recruit patients with AU at two medical centers (Kaohsiung Chang Gung Memorial Hospital and Kaohsiung Veterans General Hospital) in southern Taiwan from December 1, 2018 to March 31, 2020. These patients enrolled were reviewed for clinical diagnoses, ocular presentations, and laboratory data, including aqueous polymerase chain reaction tests.Results: A total of 112 patients were included. The most common clinical diagnoses were idiopathic AU (37.5%), HLA-B27-associated acute AU (25.0%), and herpetic AU (18.8%); among herpetic etiology, cytomegalovirus (CMV) was the most common pathogen. Hypertensive AU was associated with older age, more males, and greater numbers of corneal edema, and fewer iris posterior synechiae. Compared with HLA-B27-associated acute AU, CMV AU was associated with older age, high intraocular pressure, more keratic precipitates, greater iris atrophy, more pseudophakia, and fewer pupil posterior synechiae. Conclusion: This prospective study identified the epidemiological and clinical features of AU in southern Taiwan. The most common etiologies were idiopathic AU, HLA-B27-associated acute AU, and herpetic (most CMV) AU.

scholarly journals Epidemiology and Clinical Features of Viral Anterior Uveitis in Southern Taiwan—Diagnosis with Polymerase Chain Reaction

2019 ◽  
Author(s):  
Yu-Ting Hsiao ◽  
Ming-Tse Kuo ◽  
Wei-Yu Chiang ◽  
Tsai-Ling Chao ◽  
Hsi-Kung Kuo
Keyword(s):  
Polymerase Chain Reaction ◽  
Clinical Features ◽  
Anterior Uveitis ◽  
Case Series ◽  
Pcr Analysis ◽  
Chang Gung Memorial Hospital ◽  
Chain Reaction ◽  
Case Series Study ◽  
Southern Taiwan ◽  
Polymerase Chain

Abstract Background To report the epidemiology and clinical features of viral anterior uveitis in patients in southern Taiwan. Methods A retrospective, case series study. HLA-B27 negative anterior uveitis patients with increased intraocular pressure or corneal edema seen at Kaohsiung Chang Gung Memorial Hospital from January 1, 2007 to January 31, 2018 had their aqueous sent for polymerase chain reaction analysis. Their records were reviewed for demographic data, ocular findings, and laboratory results. Results In the aqueous samples obtained from 102 eligible eyes, 42 eyes were herpesviridae-positive, which included 9 with herpes simplex virus (8.8%), 5 with varicella-zoster virus (4.9%), 27 with cytomegalovirus (26.5%), and 1 with Epstein-Barr virus (1%). Herpesviridae-positive patients were more likely to be male, and have glaucoma. Glaucoma and pseudophakic eyes were significantly associated with CMV-positive eyes. Conclusion PCR analysis of the anterior chamber fluid is important for the confirmation of the diagnosis of viral anterior uveitis. Cytomegalovirus anterior uveitis is not uncommon in patients in southern Taiwan, and it may follow an uneventful cataract extraction in immunocompetent patients.

scholarly journals Epidemiology and Clinical Features of Viral Anterior Uveitis in Southern Taiwan—Diagnosis with Polymerase Chain Reaction

2019 ◽  
Author(s):  
Yu-Ting Hsiao ◽  
Ming-Tse Kuo ◽  
Wei-Yu Chiang ◽  
Tsai-Ling Chao ◽  
Hsi-Kung Kuo
Keyword(s):  
Polymerase Chain Reaction ◽  
Clinical Features ◽  
Anterior Uveitis ◽  
Case Series ◽  
Pcr Analysis ◽  
Chang Gung Memorial Hospital ◽  
Chain Reaction ◽  
Case Series Study ◽  
Southern Taiwan ◽  
Polymerase Chain

Abstract Background To report the epidemiology and clinical features of viral anterior uveitis in patients in southern Taiwan. Methods A retrospective, case series study. HLA-B27 negative anterior uveitis patients with increased intraocular pressure or corneal edema seen at Kaohsiung Chang Gung Memorial Hospital from January 1, 2007 to January 31, 2018 had their aqueous sent for polymerase chain reaction analysis. Their records were reviewed for demographic data, ocular findings, and laboratory results. Results In the aqueous samples obtained from 102 eligible eyes, 42 eyes were herpesviridae-positive, which included 9 with herpes simplex virus (8.8%), 5 with varicella-zoster virus (4.9%), 27 with cytomegalovirus (26.5%), and 1 with Epstein-Barr virus (1%). Herpesviridae-positive patients were more likely to be male, and have glaucoma. Glaucoma and pseudophakic eyes were significantly associated with CMV-positive eyes. Conclusion PCR analysis of the anterior chamber fluid is important for the confirmation of the diagnosis of viral anterior uveitis. Cytomegalovirus anterior uveitis is not uncommon in patients in southern Taiwan, and it may follow an uneventful cataract extraction in immunocompetent patients.

scholarly journals Epidemiology and Clinical Features of Viral Anterior Uveitis in Southern Taiwan—Diagnosis with Polymerase Chain Reaction

2019 ◽  
Author(s):  
Yu-Ting Hsiao ◽  
Ming-Tse Kuo ◽  
Wei-Yu Chiang ◽  
Tsai-Ling Chao ◽  
Hsi-Kung Kuo
Keyword(s):  
Polymerase Chain Reaction ◽  
Clinical Features ◽  
Anterior Uveitis ◽  
Case Series ◽  
Pcr Analysis ◽  
Chang Gung Memorial Hospital ◽  
Chain Reaction ◽  
Case Series Study ◽  
Southern Taiwan ◽  
Polymerase Chain

Abstract Background To report the epidemiology and clinical features of viral anterior uveitis in patients in southern Taiwan. Methods A retrospective, case series study. HLA-B27 negative anterior uveitis patients with increased intraocular pressure or corneal edema seen at Kaohsiung Chang Gung Memorial Hospital from January 1, 2007 to January 31, 2018 had their aqueous sent for polymerase chain reaction analysis. Their records were reviewed for demographic data, ocular findings, and laboratory results. Results In the aqueous samples obtained from 102 eligible eyes, 42 eyes were herpesviridae-positive, which included 9 with herpes simplex virus (8.8%), 5 with varicella-zoster virus (4.9%), 27 with cytomegalovirus (26.5%), and 1 with Epstein-Barr virus (1%). Herpesviridae-positive patients were more likely to be male, and have glaucoma. Glaucoma and pseudophakic eyes were significantly associated with CMV-positive eyes. Conclusion PCR analysis of the anterior chamber fluid is important for the confirmation of the diagnosis of viral anterior uveitis. Cytomegalovirus anterior uveitis is not uncommon in patients in southern Taiwan, and it may follow an uneventful cataract extraction in immunocompetent patients.

Clinical Features and Complications of the HLA-B27-associated Acute Anterior Uveitis: A Metanalysis

2016 ◽  
Vol 32 (6) ◽  
pp. 689-701 ◽  
Author(s):  
Enzo Maria D’Ambrosio ◽  
Maurizio La Cava ◽  
Paolo Tortorella ◽  
Magda Gharbiya ◽  
Michelangelo Campanella ◽  
...  
Keyword(s):  
Clinical Features ◽  
Anterior Uveitis ◽  
Hla B27 ◽  
Acute Anterior Uveitis

A Prospective Study of the Headache Phase in 32 Migraine with Aura Patients

Cephalalgia ◽  
2002 ◽  
Vol 22 (6) ◽  
pp. 411-415 ◽  
Author(s):  
D Cologno ◽  
P Torelli ◽  
GC Manzoni
Keyword(s):  
Prospective Study ◽  
Clinical Features ◽  
Migraine With Aura ◽  
International Headache Society ◽  
Case Series ◽  
Tension Type Headache ◽  
Pain Location ◽  
Headache Centre ◽  
Type Headache ◽  
A Prospective Study

For an accurate description of the clinical features of the headache phase in migraine with aura (MA) attacks, we thought it useful to conduct a prospective study of consecutively referred MA patients seeking treatment at the Headache Centre of the University of Parma Institute of Neurology. The case series included 32 patients (22 women and 10 men). At the time of the first visit, each patient was given a questionnaire to be filled in at the next MA attack. Six patients (four women and two men) had attacks of migraine aura without headache. Among the remaining 26 patients (18 women and eight men), the duration of the headache phase was < 24 h in 23 (88.5%); pain location was bilateral in 14 (53.8%) and unilateral in 12, but occurring on the opposite side to aura only in one patient; pain intensity was mild or moderate in 13 (50.0%). The headache phase of MA appeared to have clinical features that differed widely from patient to patient and was consistent with the International Headache Society diagnostic criteria for migraine without aura in 26.9% of patients and for tension-type headache (TTH) in 23.1%.

scholarly journals AB0687 THE PROBABILITY OF SPONDYLОARTHRITIS IN PATIENTS WITH UVEITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1639.1-1639
Author(s):  
A. Godzenko ◽  
I. Razumova ◽  
I. Guseva
Keyword(s):  
Likelihood Ratio ◽  
Clinical Features ◽  
Anterior Uveitis ◽  
Anterior Part ◽  
Clinical Parameter ◽  
Cross Sectional Study ◽  
Hla B27 ◽  
Cross Sectional ◽  
Intermediate Part ◽  
Imaging Signs

Background:Uveitis is a heterogeneous group of inflammatory eye diseases, some of which may be associated with spondyloarthritis (SpA). The probability of SpA depends on the clinical features of uveitis.Objectives:To evaluate the probability of SpA depending on the clinical features of uveitis.Methods:208 patients with uveitis referred from ophthalmologists were assessed at the Institute of Rheumathology. 139 of 208 pts had an acute recurrent course of uveitis, 69-chronic course; 149 of 208 had isolated anterior uveitis, 59 – panuveitis involving the posterior and/or intermediate part of the eye; 160 had unilateral uveitis, 48 – bilateral; 106 had HLA- В27, 102 - without HLA-В27. In addition to HLA- В27, a survey was performed to identify clinical and imaging signs of SpA, including radiography and MRI of sacroiliac joints.In 60 cases (28.8%), various SpA were identified (20 –ankylosing spondylitis, 2- reactive arthritis, 38 – non-radiographic SpA). In 148 pts SpA was not confirmed (4 of them had Behcet’s disease, 2-sarcoidosis, 4-toxoplasmosis, 29 - viral uveitis, 1 - Fux syndrome, 2 – Vogt-Koyanagi- Harada syndrome, 2 - multiple sclerosis, 104 – unspecified uveitis).Sensitivity (Se) and specificity (Sp), relative risk (RR), 95% confidence interval (CI), and likelihood ratio (LR) were calculated for each clinical parameter of uveitis with the following assessment of the probability of SpA.Results:Pretest probability of SpA in the group was 28.8%, that corresponds to pretest odds of 0.4. Among 139 pts with acute recurrent uveitis SpA was identified in 45 (32.3%), among 69 with chronic uveitis – in 15 (21.7%), RR-1.49, 95% CI [0.896, 2.475], LR-1.17. Among 149 pts with isolated anterior uveitis SpA was in 55(36.9%), among 59 with panuveitis – in 5(8.5%), RR=4.36, 95% CI [1.8, 10.3], LR-1.43. In a subgroup of 160 pts with unilateral uveitis SpA diagnosed in 51 (31.9%), in a subgroup of 48 with bilateral uveitis – in 9 (18.7%), RR = 1.7, 95% CI [0.9, 3.1], LR-1.14. Among 160 HLA-B27-positive pts SpA detected in 56 (52%), among 102 HLA-B27- negative – in 4 (3.9%), RR=13.4, 95% CI [5.1, 35.8], LR-2.7. Taking into account the pretest odds and likelihood ratio of all parameters, posttest odds was 2.7, that corresponds to posttest probability of 67%.Conclusion:A combination of such signs of uveitis as isolated localization in the anterior part of the eye, acute recurrent course, unilateral inflammation, HLA-B27, increases the probability of SpA more than 2 timesReferences:[1]Sykes M, Hamilton L, Jones C. et al. Prevalence of axial spondyloarthritis in patients with acute anterior uveitis: a cross-sectional study utilising MRIRMD Open. 2018 Feb 24;4(1):e000553. doi: 10.1136/rmdopen-2017-000553. eCollection 2018.[2]Bubová K., Gregová M., Zegzulková K. et al. Active sacroiliitis on magnetic resonance imaging in patients with anterior uveitis. Ann Rheum Dis. 2019; 78(2): A470.https://doi 10.1136/annrheumadis-2019-eular7439.Disclosure of Interests:None declared

HLA-B27 and Clinical Features of Acute Anterior Uveitis in Cuba

2012 ◽  
Vol 21 (2) ◽  
pp. 119-123 ◽  
Author(s):  
Sylvia Torres ◽  
Sandra Borges ◽  
Adriana Artiles
Keyword(s):  
Clinical Features ◽  
Anterior Uveitis ◽  
Hla B27 ◽  
Acute Anterior Uveitis

scholarly journals Clinical features of HLA-B27-positive acute anterior uveitis with or without ankylosing spondylitis in a Chinese cohort

2017 ◽  
Vol 102 (2) ◽  
pp. 215-219 ◽  
Author(s):  
Peizeng Yang ◽  
Wenjuan Wan ◽  
Liping Du ◽  
Qingyun Zhou ◽  
Jian Qi ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Clinical Features ◽  
Anterior Uveitis ◽  
Human Leucocyte Antigen ◽  
Visual Outcome ◽  
Secondary Glaucoma ◽  
Vascular Involvement ◽  
Hla B27 ◽  
Acute Anterior Uveitis ◽  
Complicated Cataract

AimsTo characterise the clinical features of human leucocyte antigen (HLA)-B27+acute anterior uveitis (AAU) patients with or without ankylosing spondylitis (AS) and investigate the retinal vascular involvement in these patients.MethodsA total of 1056 HLA-B27+ AAU patients (1525 eyes) were retrospectively studied from April 2008 to February 2016. Patients were divided into human leucocyte antigen (HLA)-B27+AS+ and HLA-B27+AS− group. Clinical features including the onset of uveitis, laterality, the age at first attack, clinical examinations, best corrected visual acuity (BCVA), abnormalities in fundus fluorescence angiography (FFA) and complications were determined and compared between these two groups.ResultsThere were 581 (55.0%) and 475 (45.0%) patients respectively classified into HLA-B27+AS+ and HLA-B27+AS− group. Males had a higher prevalence than females in the HLA-B27+AS+ group (75.2%) as compared with the HLA-B27+AS− group (51.8%, p<0.001). The HLA-B27+AS+ patients showed a higher percentage of bilateral/alternating involvement (47.3%) as compared with the HLA-B27+AS− group (36.6%, p=0.001). A higher percentage of fibrinous exudation, synechiae as well as complications including complicated cataract and secondary glaucoma were found in the HLA-B27+AS+ group as compared with the HLA-B27+AS− group. Worse visual outcome as indicated by a higher percentage of patients with BCVA <0.5 and with BCVA <0.05 was noted in the HLA-B27+AS+ group as compared with the HLA-B27+AS− group both before and after treatment. FFA showed mild capillary fluorescence leakage in the late phase with indistinctly defined margins on the peripheral retina in 39.3% of HLA-B27+ AAU patients. There was no difference concerning the retinal vascular involvement between these two groups.ConclusionsOur study confirmed that HLA-B27+AS+ patients show a higher percentage of males, more common bilateral involvement, a higher frequency of fibrinous exudates, synechiae and secondary glaucoma as compared with HLA-B27+AS− patients. Visual outcome was poorer, possibly due to the higher prevalence of complicated cataract in HLA-B27+AS+ patients. Retinal vascular involvement was not uncommon in HLA-B27+ AAU patients.

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