scholarly journals Inhibitory KIR2DL2 Receptor and HHV-8 in Classic or Endemic Kaposi Sarcoma

2022 ◽  
Author(s):  
Daria Bortolotti ◽  
Monica Corazza ◽  
Antonella Rotola ◽  
Dario Bencivelli ◽  
Giovanna Schiuma ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Killer Cell ◽  
Kaposi Sarcoma ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Blood Samples ◽  
Human Herpes Virus ◽  
Infected Cells ◽  
Immunocompetent Patients ◽  
Hiv Negative

Abstract KIR2DL2, an inhibitory Killer cell Immunoglobulin-like Receptor (KIR), has been shown to predispose to the development of several herpesvirus-associated diseases by inhibiting the efficiency of Natural Killer (NK) cells against virus-infected cells. The aim of this observational study was to assess the prevalence of KIR2DL2 and Human Herpes Virus 8 (HHV8) in patients affected with classical and endemic Kaposi sarcoma (KS), as well as in controls. Blood samples collected from 17 Caucasian, HIV-negative, immunocompetent patients affected with classical KS (c-KS), 12 African, HIV-negative patients with endemic KS (e-KS), 83 healthy subjects and 26 psoriatic patients were processed for genotypization by PCR for two KIR alleles, such as KIR2DL2 and KIR2DL3 and analyzed for HHV-8 presence. The totality of both c-KS and e-KS patients presented HHV-8 infection, whereas HHV8 was found in 26.9% of psoriatic subjects and 19.3% of healthy subjects. KIR2DL2 was found in the 76.5% of c-KS subjects, while the receptor was found in 41.7% of the e-KS group, 34.6% of psoriatic patients and 43.4% of healthy controls (p<0.0001). A significantly higher prevalence of KIR2DL2 in c-KS patients than in all the other subjects was also confirmed comparing age-matched groups. Based on these results, the inhibitory KIR2DL2 genotype appears to be a possible cofactor which increases the risk of developing c-KS in HHV8-positive, immunocompetent subjects, while it seems less relevant in e-KS pathogenesis.

scholarly journals Rare presentation of bronchopulmonary Kaposi sarcoma

2019 ◽  
Vol 12 (8) ◽  
pp. e229436
Author(s):  
Raiko Diaz ◽  
Patricia Almeida ◽  
Dionne Morgan
Keyword(s):  
Rare Case ◽  
Kaposi Sarcoma ◽  
Developed Countries ◽  
Atypical Presentation ◽  
Human Herpes ◽  
Rare Presentation ◽  
Human Herpes Virus 8 ◽  
Visceral Involvement ◽  
Human Herpes Virus ◽  
Undiagnosed Hiv

Kaposi sarcoma (KS) is an angioproliferative disorder that is commonly associated with human herpes virus 8 as well as the HIV. In fact, KS is one of the most common AIDS-defining illnesses. KS typically presents with diffuse, violaceous cutaneous nodules, and may have concomitant visceral involvement. However, visceral involvement rarely occurs without skin manifestations. A rare case of localised bronchopulmonary KS without skin involvement is described in a patient with previously undiagnosed HIV. This atypical presentation represents a challenge for modern-day physicians in developed countries where the prevalence of AIDS-related diseases is decreasing.

scholarly journals Prevalence of Human Herpes Virus 8 Infection and Pattern of TLR4 rs4986791 Polymorphism in Women with Breast Cancer

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Majid Komijani ◽  
Ahmad Hamta ◽  
Sajedeh Khanmohamadi Hezaveh
Keyword(s):  
Breast Cancer ◽  
Significant Relationship ◽  
Healthy Subjects ◽  
Herpes Virus ◽  
Cancer Development ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Risk Of Cancer

Background: Breast cancer is a major cause of female death worldwide. Several factors contribute to cancer development, one of the most important of which is viruses identified by the host immune system and Toll-like receptors (TLRs). Human herpes virus 8 (HHV-8) is one of the viruses with a proven role in Kaposi’s sarcoma development. Objectives: This study aimed to investigate the correlation between HHV-8 infection and breast cancer, as well as the role of rs4986791 polymorphism in women’s health. Methods: Blood samples of 80 healthy subjects and 80 patients suffering from breast cancer were collected (from May-September 2018). The presence of HHV-8 in the samples was examined by PCR. Also, the rs4986791 polymorphism was evaluated by nested PCR-RFLP. Results: The results showed a significant relationship between age and breast cancer. Of 80 cancer patients and 80 healthy subjects, 17 (21.3%) and 15 (18.8%) were carriers of HHV-8, respectively. Also, there was no significant relationship between HHV-8 infection and breast cancer (P = 0.693). We found no significant relationship between the presence of virus and cancer grade (P = 0.618). Conclusions: The results of rs498679 polymorphism analysis indicated that the T allele was associated with increased health phenotype and decreased risk of cancer development. Also, women with TT genotype exhibited significantly lower HHV-8 infection than the other genotypes.

Primary Penile Kaposi Sarcoma in an HIV-negative 21-year-old Male

2014 ◽  
Vol 10 (02) ◽  
pp. 2
Author(s):  
Sophie Momen ◽  
Cathy Corbishley ◽  
Ruth Pettengell ◽  
Ben Ayres ◽  
Jens Samol ◽  
...  
Keyword(s):  
Clinical Evidence ◽  
Sexual Transmission ◽  
Kaposi Sarcoma ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
First Case ◽  
Local Surgery ◽  
Complete Clinical Remission ◽  
History Of ◽  
Hiv Negative

We present a 21-year-old HIV-negative Somalian male who was diagnosed with an immunohistochemically proven human herpes virus 8 (HHV8)-positive primary penile Karposi’s Sarcoma (KS). He was treated with local surgery and remained in complete clinical remission for 18 months. This is the first case of a heterosexual teenage and young adult (TYA) patient diagnosed with a primary penile KS without a history of sexual intercourse. This case provides clinical evidence that KS may be transmitted through routes other than sexual transmission.

scholarly journals Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men

1999 ◽  
Vol 14 (5) ◽  
pp. 1231-1234 ◽  
Author(s):  
V. Ascoli ◽  
C. Carnovale Scalzo ◽  
C. Danese ◽  
K. Vacca ◽  
A. Pistilli ◽  
...  
Keyword(s):  
Herpes Virus ◽  
Pleural Cavity ◽  
Primary Effusion Lymphoma ◽  
Human Herpes ◽  
Elderly Men ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Hiv Negative

scholarly journals Isolated Kaposi Sarcoma of the Tonsil: A Case Report and Review of the Scientific Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Barbara Pittore ◽  
Carlo Loris Pelagatti ◽  
Francesco Deiana ◽  
Francesco Ortu ◽  
Elena Maricosu ◽  
...  
Keyword(s):  
Case Report ◽  
Herpes Virus ◽  
Scientific Literature ◽  
Kaposi Sarcoma ◽  
Hiv Positive ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
The Right

Kaposi sarcoma is a tumour caused by human herpes virus 8, also known as Kaposi sarcoma-associated herpes virus. It usually affects the skin and oral mucosa; however, it can also sometimes affect the lungs, the liver, the stomach, the bowel, and lymph nodes. Several body sites may be affected simultaneously. The involvement of the tonsils is rare. We described an isolated localization of Kaposi’s sarcoma of the right tonsil in a HIV-positive patient.

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